Microstructural Changes in the Retina Related to Prematurity

Pueyo, Victoria; González, Inmaculada; Altemir, Irene; Pérez, Tania; Gómez, Galadriel; Prieto, Esther; Orós, Daniel

doi:10.1016/j.ajo.2014.12.015

Cited by 44 publications

(62 citation statements)

References 29 publications

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“…In addition, the study speculated that the retention of the inner retina might contribute to the abnormal foveal morphology in patients with a history of ROP. Several studies have reported a thick fovea in premature children and have associated it with early GA and/or low BW [5, 7, 8]. Similarly, our study demonstrated that the eyes in the ROP group had the greatest foveal thickness of all groups.…”

Section: Discussionsupporting

confidence: 82%

Foveal Depression and Related Factors in Patients with a History of Retinopathy of Prematurity

Miki¹,

Honda²,

Inoue³

et al. 2018

Ophthalmologica

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Purpose: This study evaluates optical coherence tomography (OCT) findings of the macula in patients with a history of retinopathy of prematurity (ROP). Methods: We enrolled 112 patients (age: 6–15 years) and categorized them into 3 groups: gestational age (GA) < 36 weeks with or without a history of ROP (ROP group, preterm group) and GA ≥37 weeks. We included 1 eye of each patient and measured the retinal thickness of the macula by OCT. Results: The ROP group demonstrated the worst VA and the shallowest foveal depression. Furthermore, foveal depression significantly correlated with birth weight, GA, ganglion cell layer/inner plexiform layer (GCL-IPL) thickness, and a history of ROP. Conclusions: This study established a correlation of fovea formation with premature birth, damage of GCL-IPL, and a history of ROP. The retention of the inner retina possibly contributes to abnormal foveal morphology in patients with a history of ROP.

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Section: Discussionsupporting

confidence: 82%

Foveal Depression and Related Factors in Patients with a History of Retinopathy of Prematurity

Miki¹,

Honda²,

Inoue³

et al. 2018

Ophthalmologica

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“…9 We suggest that the relation between supranormal thickening of the temporal RNFL and decreased GCL_IPL thickness must be questioned further.…”

Section: Discussionmentioning

confidence: 84%

“…Similar deviations have been found in subjects treated with laser photocoagulation for ROP. 6,9,11 Another important finding was the difficulties in the automatic analysis of the GCL_IPL thickness in the macular area.…”

Section: Discussionmentioning

confidence: 99%

“…Pueyo et al 9 reported on the thickness of the ganglion cell complex (GCL_IPL thickness), including the ganglion cell layer (GCL) and inner plexiform layer (IPL) in the macula. They found that ROP-treated ex-preterms had a severely reduced minimum GCL_IPL thickness compared to controls, while there was no difference between the group of nontreated ROP infants and controls.…”

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confidence: 99%

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Retinal Sequelae in Adults Treated With Cryotherapy for Retinopathy of Prematurity

Nilsson

Hellström

Jacobson

2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Cryotherapy, introduced in the mid-1980s, was the first treatment of severe retinopathy of prematurity (ROP) and resulted in ablation of larger retinal areas than did its later substitute, laser treatment. We defined the characteristics of the retinal structure and assessed visual function, in adult ex-preterms treated with cryotherapy. METHODS.A total of 28 ex-preterms, included in a prospective study of infants born in Stockholm between September 1988 and March 1993, were treated with cryotherapy because of severe ROP. Of these individuals, 14 took part in this follow-up study and underwent ophthalmologic assessment including visual acuity, fundus photography, perimetry, and retinal imaging using optical coherence tomography (OCT) in their third decade of life. Their gestational ages were 24 to 28 (median 25) weeks at birth.RESULTS. The ex-preterms had reduced foveal depth (P < 0.0001) and increased thickness of the temporal retinal nerve fiber layer (RNFL; P > 0.001). A thicker temporal RNFL was not correlated with a thicker ganglion cell layer (P ¼ 0.41, r ¼ 0.29) as in controls (P ¼ 0.0015, r ¼ 0.78). Extreme thickening was seen in patients with pronounced retinal dragging. CONCLUSIONS.In their third decade of life, ex-preterm adults treated with cryotherapy for ROP have major microstructural retinal abnormalities in terms of reduced foveal depth and an altered distribution of the peripapillary RNFL. The main contributors seem to be gestational age and ROP rather than the cryotherapy. The possibility to evaluate the retinal structure in these individuals, with today's conventional OCT, is limited by those anatomic deviations.

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“…5,[38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] Optic nerve morphology is altered in preterm children, with global decreases and segmental (temporal) increases in RNFL thickness measurements being reported. 27,53,56,57 Choroidal thickness, which normally increases with age, is reduced in preterm children. 45,50,[58][59][60] Iridocorneal angle development and morphology are also affected, with evidence of a wider angle, a more convex iris configuration, and a shallower anterior chamber depth.…”

Section: Retinopathy Of Prematuritymentioning

confidence: 99%

Pediatric Optical Coherence Tomography in Clinical Practice—Recent Progress

Lee

Proudlock

Gottlob

2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Lee H, Proudlock FA, Gottlob I. Pediatric optical coherence tomography in clinical practice-recent progress. Invest Ophthalmol Vis Sci. 2016;57:OCT69-OCT79. DOI:10.1167/iovs.15-18825 PURPOSE. Optical coherence tomography (OCT) has revolutionized the diagnosis and management of adult retinal and optic nerve disease. Children were deprived of this technology until the recent development of handheld spectral-domain OCT (HH-SDOCT). In this article, we review the applications of OCT imaging in pediatric ophthalmology.METHODS. This study was a review of the literature.RESULTS. The acquisition and interpretation of pediatric tomograms differ significantly from those for adults, with adjustments needed to account for the shorter axial lengths, higher refractive errors, and ongoing retinal and optic nerve development in the pediatric eye. Handheld SDOCT is increasingly being used as an adjunctive diagnostic tool in retinopathy of prematurity (ROP) and nonaccidental injury (NAI) by providing additional morphologic information that is not normally clinically discernible. The role of HH-SDOCT in streamlining diagnosis in infantile nystagmus syndrome, retinal dystrophies, and degenerations has been established. Optical coherence tomography can also help differentiate between pediatric intraocular tumors, for example, hamartomas and retinoblastoma; monitor tumor progression; and monitor treatment response. In addition, HH-SDOCT is establishing its role as a noninvasive monitoring tool in children affected by optic nerve pathology such as glaucoma, optic nerve atrophy and hypoplasia, optic pathway glioma, and pseudotumor cerebri. CONCLUSIONS.Handheld SDOCT can provide novel insights into the natural history of retinal and optic nerve diseases in young children. For example, in achromatopsia and albinism, in vivo OCT studies have provided evidence of altered but ongoing retinal development in early childhood, which suggests that potentially targeting treatment at an earlier age may optimize visual function by normalizing retinal development.

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Microstructural Changes in the Retina Related to Prematurity

Cited by 44 publications

References 29 publications

Foveal Depression and Related Factors in Patients with a History of Retinopathy of Prematurity

Foveal Depression and Related Factors in Patients with a History of Retinopathy of Prematurity

Retinal Sequelae in Adults Treated With Cryotherapy for Retinopathy of Prematurity

Pediatric Optical Coherence Tomography in Clinical Practice—Recent Progress

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