Protocolo de cirugía de rescate guiada por PET/TAC. Resultados con técnica ROLL y sonda PET

García, J.R.; Fraile, Manuel; Solèr, M.; Bechini, Jordi; Ayuso, Juan Ramón; Lomeña, Francisco

doi:10.1016/j.remn.2011.02.011

Cited by 14 publications

(4 citation statements)

References 13 publications

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“…García et al. ( 10 ) compared the use of the PET-probe and ROLL techniques for intraoperative localization of lesions previously detected by PET/CT. The authors suggested that ROLL is the technique of choice for solitary lesions of easy percutaneous access with a biopsy needle and that a PET probe should be used only for lesions that are not eligible for the percutaneous approach.…”

Section: Discussionmentioning

confidence: 99%

Computed tomography-guided preoperative localization of musculoskeletal lesions using the ROLL technique

et al. 2018

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ObjectiveTo describe the preoperative localization of musculoskeletal lesions with the radioguided occult lesion localization (ROLL) technique.Materials and MethodsIn all cases, computed tomography-guided injection of technetium-99m sulfur colloid was performed, directly into or near the suspicious lesion, up to 36 hours before the surgical procedure. Lesions were detected intraoperatively with a gamma probe.ResultsWe report the cases of six patients submitted to radioguided surgery, including three patients with bone lesions suspicious for metastasis, two patients suspected of recurrent sarcoma, and one patient with no previous diagnosis who had a nodular lesion on the left leg. Patients tolerated the procedure well, and no complications were associated with the puncture. All marked lesions were easily identified intraoperatively and were excised with clear margins.ConclusionThe ROLL technique was effective in the intraoperative localization of occult musculoskeletal lesions, demonstrating that it is a feasible and promising technique for the surgical exploration of selected cases.

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Section: Discussionmentioning

confidence: 99%

Computed tomography-guided preoperative localization of musculoskeletal lesions using the ROLL technique

et al. 2018

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“…In order to attempt to bypass these physical barriers related to the degree of physical side shielding/collimation or crystal diameter/thickness in designing intraoperative hand-held gamma probes that are specifically intended for attempting to detect 511 KeV gamma emissions from higher energy gamma photon emitting/positron emitting radionuclides, engineering efforts have moved toward other directions for the adaptation of more novel “PET” probe designs that do not rely upon increasing physical side shielding/collimation or increasing crystal diameter/thickness. Examples of such alternative design concepts that can be adapted to “PET” probe design are secondary K-alpha x-ray fluorescence [ 70 , 78 ], active electronic collimation [ 28 , 54 , 58 , 60 , 67 , 79 - 81 ], and other crystal geometry designs using multiple small crystals with specific novel geometric configurations [ 82 , 83 ] for optimizing background rejection capabilities. These innovative alternative design schemas for detecting higher energy gamma photon emitting/positron emitting radionuclides, some of which have already been successfully applied to intraoperative hand-held gamma probe designs, are also the focus of current pre-clinical research that is actively looking at developing small platform, portable perioperative and intraoperative patient and ex vivo surgical specimen imaging devices with similar capabilities for detecting higher energy gamma photon emitting/positron emitting radionuclides.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of a multimodal 18F-FDG-directed lymph node surgical excisional biopsy approach for appropriate diagnostic tissue sampling in patients with suspected lymphoma

et al. 2015

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Background18F-FDG PET/CT imaging is widely utilized in the clinical evaluation of patients with suspected or documented lymphoma. The aim was to describe our cumulative experience with a multimodal 18F-FDG-directed lymph node surgical excisional biopsy approach in patients with suspected lymphoma.MethodsThirteen patients (mean age 51 (±16;22–76) years), with suspected new or suspected recurrent lymphoma suggested by 18F-FDG-avid lesions seen on prior diagnostic whole-body PET/CT imaging, were injected IV with 18F-FDG prior to undergoing same-day diagnostic lymph node surgical excisional biopsy in the operating room. Various 18F-FDG detection strategies were used on the day of surgery, including, (1) same-day pre-resection patient PET/CT; (2) intraoperative gamma probe assessment; (3) clinical scanner specimen PET/CT imaging of whole surgically excised tissue specimens; (4) specimen gamma well counts; and/or (5) same-day post-resection patient PET/CT.ResultsSame-day 18F-FDG injection dose was 14.8 (±2.4;12.5-20.6) millicuries or 548 (±89;463–762) megabecquerels. Sites of 18F-FDG-avid lesions were 4 inguinal, 3 cervical, 3 abdominal/retroperitoneal, 2 axillary, and 1 gluteal region subcutaneous tissue. Same-day pre-resection patient PET/CT was performed on 6 patients. Intraoperative gamma probe assessment was performed on 13 patients. Clinical scanner PET/CT imaging of whole surgically excised tissue specimens was performed in 10 cases. Specimen gamma well counts were performed in 6 cases. Same-day post-resection patient PET/CT imaging was performed on 8 patients. Time from 18F-FDG injection to same-day pre-resection patient PET/CT, intraoperative gamma probe assessment, and same-day post-resection patient PET/CT were 76 (±8;64–84), 240 (±63;168–304), and 487 (±104;331–599) minutes, respectively. Time from 18F-FDG injection to clinical scanner PET/CT of whole surgically excised tissue specimens was 363 (±60;272–446) minutes. Time from 18F-FDG injection to specimen gamma well counts was 591 (±96;420–689) minutes. Intraoperative gamma probe assessment successfully identified 18F-FDG-avid lesions in 12/13 patients. Histopathologic evaluation confirmed lymphoma in 12/13 patients and benign disease in 1/13 patients.ConclusionsA multimodal approach to 18F-FDG-directed lymph node surgical excisional biopsy for suspected lymphoma is technically feasible for guiding appropriate diagnostic tissue sampling of lymph nodes seen as 18F-FDG-avid lesions on diagnostic 18F-FDG PET/CT imaging.

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“…Hace algunos años la ROLL comenzó a ser utilizada como técnica quirúrgica en patologías tumorales no mamarias, como es el caso de recurrencias cervicales de cáncer diferenciado de tiroides confirmadas previamente mediante PAAF 2,14 . Varios autores han descrito buenos resultados al ser utilizada como técnica de cirugía de rescate tras estudio PET-TAC, realizándose en algunas publicaciones igualmente confirmación previa con PAAF 10,15 . En otros trabajos la técnica ROLL fue aplicada satisfactoriamente como método de biopsia excisional con intención diagnóstica 6,16 .…”

Section: Discussionunclassified

Aplicación clínica de la técnica ROLL en patología no mamaria. Uso complementario tras estudio PET-TAC

Infante¹,

Rayo²,

Serrano³

et al. 2015

Revista Española de Medicina Nuclear e Imagen Molecular

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Protocolo de cirugía de rescate guiada por PET/TAC. Resultados con técnica ROLL y sonda PET

Cited by 14 publications

References 13 publications

Computed tomography-guided preoperative localization of musculoskeletal lesions using the ROLL technique

Computed tomography-guided preoperative localization of musculoskeletal lesions using the ROLL technique

Feasibility of a multimodal 18F-FDG-directed lymph node surgical excisional biopsy approach for appropriate diagnostic tissue sampling in patients with suspected lymphoma

Aplicación clínica de la técnica ROLL en patología no mamaria. Uso complementario tras estudio PET-TAC

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