Protocol paper: Stepped wedge cluster randomized trial translating the ABCS into optimizing cardiovascular care for people living with HIV

Williams, Stephen; Johnson, Brent A.; Luque, Amneris E.; Sanders, Mechelle; Carroll, Jennifer K.; Cassells, Andrea; Holder, Tameir; Fiscella, Kevin

doi:10.1016/j.pcad.2020.02.003

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…For instance, we observed variability in reporting IS TMFs across trials (see Table 3), and only Garner et al [19 ▪▪ ] included Standards for Reporting Implementation Studies [25]. However, we were encouraged to identify numerous protocols describing planned hybrid type 1 [26,27,28 ▪ ,29 ▪ ,30,31], type 2 [32 ▪ ,33,34], and type 3 [35 ▪ ,36,37,38 ▪ ] trials, and completed implementation trials and programs [39,40 ▪▪ ,41 ▪▪ ].…”

Section: Opportunities For Implementation Science To Strengthen Socia...mentioning

confidence: 99%

Moving toward equity: fostering transdisciplinary research between the social and behavioral sciences and implementation science to end the HIV epidemic

Pyra

Motley

Bouris

2022

Current Opinion in HIV and AIDS

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Purpose of reviewSince the beginning of the HIV epidemic, social and behavioral scientists have developed interventions to stem the spread of the virus. The dissemination of these interventions has traditionally been a lengthy process; however, implementation science (IS) offers a route toward hastening delivery of effective interventions. A transdisciplinary approach, wherein IS informs and is informed by social and behavioral sciences (SBS) as well as community participation, offers a strategy for more efficiently moving toward health equity and ending the HIV epidemic. Recent findingsThere has been considerable growth in HIV research utilizing IS theories, methods and frameworks. Many of these studies have been multi or interdisciplinary in nature, demonstrating the ways that IS and SBS can strengthen one another. We also find areas for continued progress toward transdisciplinarity.

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Section: Opportunities For Implementation Science To Strengthen Socia...mentioning

confidence: 99%

Moving toward equity: fostering transdisciplinary research between the social and behavioral sciences and implementation science to end the HIV epidemic

Pyra

Motley

Bouris

2022

Current Opinion in HIV and AIDS

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“…One recent paper provided a qualitative evaluation of PrEP-focused academic detailing interventions in New England and NYC, identifying several specific challenges but without quantitative assessment of impact. 82 Some publications have explored academic detailing for other elements of HIV care, including HIV testing 76,83−85 and the treatment of opioid use disorder 86,87 and cardiovascular conditions 88 among people living with HIV. Although academic detailing itself already has a substantial evidence base, applying the approach to PrEP prescribing can require some adaptation of the model.…”

Section: Future Pathways and Prioritiesmentioning

confidence: 99%

Academic Detailing to Increase Prescribing of HIV Pre-exposure Prophylaxis

Krakower

Naja-Riese

Edelstein

et al. 2021

American Journal of Preventive Medicine

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Although HIV pre-exposure prophylaxis can decrease new cases of HIV by up to 99%, many patients who could benefit from pre-exposure prophylaxis never receive prescriptions for it. Because pre-exposure prophylaxis is indicated for patients who do not have an infectious disease, increasing pre-exposure prophylaxis prescribing by primary care and generalist clinicians represents a key element of the Ending the HIV Epidemic in the U.S. initiative. This review provides an overview of academic detailing and how it is currently being used to increase pre-exposure prophylaxis prescribing. Academic detailing is outreach education that engages with clinicians in 1-to-1 or small group interactions focused on identifying and addressing an individual clinician's needs to increase their use of evidence-based practices. Academic detailing has been proven in multiple previous research studies, and the principles required for successful implementation include interactivity, clinical relevance of content, and focus on defined behavior change objectives. Clinician barriers to pre-exposure prophylaxis prescribing may occur in the domains of knowledge, attitudes, or behavior, and academic detailing has the potential to address all of these areas. State and local health departments have developed academic detailing programs focused on pre-exposure prophylaxis prescribing and other elements of HIV prevention-sometimes describing the approach as public health detailing. Few studies of academic detailing for preexposure prophylaxis have been published to date; rigorous evaluation of HIV-specific adaptations and innovations of the approach would represent an important contribution. In the setting of the COVID-19 pandemic, interest in virtual delivery of academic detailing has grown, which could inform efforts to implement academic detailing in rural communities and other underserved areas. Increasing this capacity could make an important contribution to Ending the HIV Epidemic in the U.S. and other HIV prevention efforts.

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“…The trial, Implementation Research: Translating the ABCS into HIV Care (5U01HL142107-02), is a stepped wedge, cluster, randomized trial to test implementation strategies designed to promote uptake of evidence-based cardiovascular interventions for People Living with HIV. 3 Implementation strategies target patient, clinician and practice participants. The trial involves recruitment of 600, largely low-income and minority patients and 40–60 clinicians who care for these patients across nine separate practices, largely serving low-income and minority patients from three geographic regions (NYC; Rochester, NY; and Dallas, TX).…”

mentioning

confidence: 99%

COVID-19 impact on multi-site recruitment and enrollment

et al. 2020

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Clinical trial recruitment is challenging, 1 particularly for socially disadvantaged patients. 2 The COVID-19 pandemic has amplified this challenge. In this research letter, we report on adaptations we made to participant recruitment processes for a clinical trial conducted across three geographic regions impacted by COVID-19 and their impact on recruitment. The trial, Implementation Research: Translating the ABCS into HIV Care (5U01HL142107-02), is a stepped wedge, cluster, randomized trial to test implementation strategies designed to promote uptake of evidencebased cardiovascular interventions for People Living with HIV. 3 Implementation strategies target patient, clinician and practice participants. The trial involves recruitment of 600, largely low-income and minority patients and 40-60 clinicians who care for these patients across nine separate practices, largely serving lowincome and minority patients from three geographic regions (NYC; Rochester, NY; and Dallas, TX). 4 Patients must have HIV, be 40-75 years, at ø5% 10year risk for atherosclerotic cardiovascular disease using the ASCVD Risk Estimator Plus, 4 be willing to participate, be proficient in English or Spanish, own a cell phone with texting capabilities and be approved by the consented clinician. Recruitment involves identification of potentially eligible participants using electronic health record data, 5 communication between the clinician and research assistant, referral by the clinician and communication between the prospective participant and the research assistant. Beginning 9-10 March 2020, all sites from Dallas, NYC and Rochester experienced a sudden, institutionally, COVID-19-mandated shutdown of in-person clinical and research activities. Hospitals and Federally Qualified Health Centers quickly transitioned all nonemergent/urgent patient visits to telehealth visits by video or phone, often from clinicians' homes. 6 These transformative changes required immediate adaptations for our research interventions, 7 for example, shifting

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Protocol paper: Stepped wedge cluster randomized trial translating the ABCS into optimizing cardiovascular care for people living with HIV

Cited by 8 publications

References 36 publications

Moving toward equity: fostering transdisciplinary research between the social and behavioral sciences and implementation science to end the HIV epidemic

Moving toward equity: fostering transdisciplinary research between the social and behavioral sciences and implementation science to end the HIV epidemic

Academic Detailing to Increase Prescribing of HIV Pre-exposure Prophylaxis

COVID-19 impact on multi-site recruitment and enrollment

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