Protocol Management Of Severe Traumatic Brain Injury In Intensive Care Units: A Systematic Review

English, Shane; Turgeon, Alexis F.; Owen, Elliott; Doucette, Steve; Pagliarello, Giuseppe; McIntyre, Lauralyn

doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2375

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“…For obvious ethical reasons, a prospective randomized controlled clinical study concerning the adverse effects of secondary insults on outcomes from TBI has never been done [1,4]. However, an increasing body of experimental results and clinical retrospective studies in the past few decades have demonstrated that such secondary insults occurred frequently after TBI and exerted a powerful, detrimental influence on recovery from TBI [1,[5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Where are we in the modelling of traumatic brain injury? Models complicated by secondary brain insults

et al. 2014

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A more complete understanding of the interactions between the injured brain and secondary insults represents a potentially fruitful avenue that may increase the likelihood of developing effective therapies. Experimental models of TBI should not only attempt to model the focal or diffuse changes resulting from external forces, but also integrate, when appropriate, secondary insults reminiscent of human situations.

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