Protocatechuic aldehyde inhibits hepatitis B virus replication both in vitro and in vivo

Zhou, Zhe; Zhang, Yi; Ding, Xiaoran; Chen, Suhong; Yang, Jing; Wang, Xuejun; Jia, Gao-Long; Chen, Hongshan; Bo, Xiaochen; Wang, Shengqi

doi:10.1016/j.antiviral.2006.12.005

Cited by 92 publications

(56 citation statements)

References 20 publications

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“…The pharmacology of PAL is, however, still unclear. Some pharmacological studies have shown that PAL possesses a number of biological activities, including inhibition of HBV DNA replication and HBV antigen expression (28) and inhibition of cytokine-induced VCAM-1 and ICAM-1 expression (29). In this study, we found that PAL has DJ-1-dependent anti-oxidative activity.…”

Section: Discussionsupporting

confidence: 49%

DJ-1–Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells

et al. 2011

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Abstract. DJ-1 was identified as a causal gene for a familial form of early onset Parkinson's disease (PD), park 7. DJ-1 plays roles in transcriptional regulation and the anti-oxidative stress reaction. In this study, we found that protocatechuic aldehyde (PAL), a traditional Chinese medicine compound, bound to DJ-1 in vitro and that PAL protected SH-SY5Y cells but not DJ-1-knockdown SH-SY5Y cells from oxidative stress-induced cell death, indicating that the protective effect of PAL is mediated by DJ-1. Furthermore, PAL inhibited production of reactive oxygen species and the inhibition was abated in DJ-1-knockdown cells. PAL increased and decreased phosphorylation of AKT and PTEN, respectively, in SH-SY5Y cells, suggesting that the AKT pathway is one of the specific signaling pathways in PAL-induced neuroprotection. Moreover, PAL prevented superfluous oxidation of cysteine 106 of DJ-1, an essential amino acid for DJ-1's function. The present study demonstrates that PAL has potential neuroprotective effects through DJ-1.

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Section: Discussionsupporting

confidence: 49%

DJ-1–Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells

et al. 2011

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“…These roles may take place at the transcription and post-transcription levels. 31) Therefore, the HBV mRNA level was determined in HepG2.2.15 cells. The results revealed that HBV antigen inhibition by cinobufacini, bufalin, and cinobufagin was attributed to the specific inhibition of HBV mRNA expression.…”

Section: Discussionmentioning

confidence: 99%

Anti-hepatitis B Virus Activities of Cinobufacini and Its Active Components Bufalin and Cinobufagin in HepG2.2.15 Cells

Cui

Inagaki

et al. 2010

Biological & Pharmaceutical Bulletin

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“…This role may take place at the transcription level (22). HBV enhancers, the transcriptional regulatory DNA fragments, may mediate the transcriptional suppression by binding several transcription factors.…”

Section: Discussionmentioning

confidence: 99%

The supercritical CO2 extract from the skin of Bufo bufo gargarizans Cantor blocks hepatitis B virus antigen secretion in HepG2.2.15 cells

Cui

Inagaki

Wang

et al. 2014

BST

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Protocatechuic aldehyde inhibits hepatitis B virus replication both in vitro and in vivo

Cited by 92 publications

References 20 publications

DJ-1–Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells

DJ-1–Mediated Protective Effect of Protocatechuic Aldehyde Against Oxidative Stress in SH-SY5Y Cells

Anti-hepatitis B Virus Activities of Cinobufacini and Its Active Components Bufalin and Cinobufagin in HepG2.2.15 Cells

The supercritical CO2 extract from the skin of Bufo bufo gargarizans Cantor blocks hepatitis B virus antigen secretion in HepG2.2.15 cells

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