Protocatechuic Acid Prevents Early Hour Ischemic Reperfusion Brain Damage by Restoring Imbalance of Neuronal Cell Death and Survival Proteins

Kale, Swapnil; Sarode, Lopmudra P.; Kharat, Amol; Ambulkar, Saurabh; Prakash, Anand; Sakharkar, Amul J.; Ugale, Rajesh R.

doi:10.1016/j.jstrokecerebrovasdis.2020.105507

Cited by 14 publications

(3 citation statements)

References 45 publications

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“…Similar to these results, treatment with ethanolic pine needle extract increased the expression levels of BDNF and p-CREB against scopolamine-induced hippocampal dysfunction [ 81 ]. In addition, PCA, a physiologically active substance of KRPBE, showed an anti-apoptotic effect by significantly increasing the BDNF level, the CREB target gene, under chronic intermittent hypoxia [ 82 ]. Based on these results, the administration of KRPBE significantly increased the antioxidant system capacity and mitochondrial activity in Aβ-induced cognitive decline mice.…”

Section: Discussionmentioning

confidence: 99%

Korean Red Pine (Pinus densiflora) Bark Extract Attenuates Aβ-Induced Cognitive Impairment by Regulating Cholinergic Dysfunction and Neuroinflammation

Kim

Kang

et al. 2022

J. Microbiol. Biotechnol.

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In this study, we investigated the anti-amnesic effect of Korean red pine (Pinus densiflora) bark extract (KRPBE) against amyloid beta 1-42 (Aβ 1-42 )-induced neurotoxicity. We found that treatment with KRPBE improved the behavioral function in Aβ-induced mice, and also boosted the antioxidant system in mice by decreasing malondialdehyde (MDA) content, increasing superoxide dismutase (SOD) activities, and reducing glutathione (GSH) levels. In addition, KRPBE improved the cholinergic system by suppressing reduced acetylcholine (ACh) content while also activating acetylcholinesterase (AChE), regulating the expression of choline acetyltransferase (ChAT), postsynaptic density protein-95 (PSD-95), and synaptophysin. KRPBE also showed an ameliorating effect on cerebral mitochondrial deficit by regulating reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and ATP levels. Moreover, KRPBE modulated the expression levels of neurotoxicity indicators Aβ and phosphorylated tau (p-tau) and inflammatory cytokines TNF-α, p-IκB-α, and IL-1β. Furthermore, we found that KRPBE improved the expression levels of neuronal apoptosis-related markers BAX and BCl-2 and increased the expression levels of BDNF and p-CREB. Therefore, this study suggests that KRPBE treatment has an anti-amnestic effect by modulating cholinergic system dysfunction and neuroinflammation in Aβ 1-42 -induced cognitive impairment in mice.

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Section: Discussionmentioning

confidence: 99%

Korean Red Pine (Pinus densiflora) Bark Extract Attenuates Aβ-Induced Cognitive Impairment by Regulating Cholinergic Dysfunction and Neuroinflammation

Kim

Kang

et al. 2022

J. Microbiol. Biotechnol.

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“…P-5630, CAS number 99-50-3) (i.p., 150 mg/kg dissolved in NaCl 0.9% with dymethyl sulfoxide [DMSO] 1%). This concentration was selected based on comparative studies of the effects of PCA on brain induced-damage in rats (doses of 10–50 mg/kg for direct and intraperitoneal administration) ( Kale et al. 2021 ) and existing evidence of brain uptake and plasma levels of phenolic metabolites generated following the ingestion of polyphenol-rich foods ( Gasperotti et al.…”

Section: Methodsmentioning

confidence: 99%

A dietary polyphenol metabolite alters CA1 excitability ex vivo and mildly affects cortico-hippocampal field potential generators in anesthetized animals

Montero-Atalaya,

Expósito,

Muñoz-Arnaiz

et al. 2023

Cerebral Cortex

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Dietary polyphenols have beneficial effects in situations of impaired cognition in acute models of neurodegeneration. The possibility that they may have a direct effect on the electrical activity of neuronal populations has not been tested. We explored the electrophysiological action of protocatechuic acid (PCA) on CA1 pyramidal cells ex vivo and network activity in anesthetized female rats using pathway-specific field potential (FP) generators obtained from laminar FPs in cortex and hippocampus. Whole-cell recordings from CA1 pyramidal cells revealed increased synaptic potentials, particularly in response to basal dendritic excitation, while the associated evoked firing was significantly reduced. This counterintuitive result was attributed to a marked increase of the rheobase and voltage threshold, indicating a decreased ability to generate spikes in response to depolarizing current. Systemic administration of PCA only slightly altered the ongoing activity of some FP generators, although it produced a striking disengagement of infraslow activities between the cortex and hippocampus on a scale of minutes. To our knowledge, this is the first report showing the direct action of a dietary polyphenol on electrical activity, performing neuromodulatory roles at both the cellular and network levels.

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“…Protocatechuic acid (PA) and gallic acid (GA), natural components of green tea, are benzoic acid derivatives with strong free-radical scavenging effects [222,223]. In a rat model of focal cerebral ischemia, early administration of PA increased CREB expression in the rat brain and prevented cerebral I/R injury [209]. GA was found to induce microglial polarization to the M2 type after mouse brain I/R injury, reduce inflammatory factor secretion, and regulate tight junction-related protein expression to protect the BBB and mitigate cerebral injury [210].…”

Section: Benzoic Acid Derivativesmentioning

confidence: 99%

Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights

et al. 2022

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Ischemic stroke (IS) is a leading cause of death and disability worldwide. Currently, the main therapeutic strategy involves the use of intravenous thrombolysis to restore cerebral blood flow to prevent the transition of the penumbra to the infarct core. However, due to various limitations and complications, including the narrow time window in which this approach is effective, less than 10% of patients benefit from such therapy. Thus, there is an urgent need for alternative therapeutic strategies, with neuroprotection against the ischemic cascade response after IS being one of the most promising options. In the past few decades, polyphenolic compounds have shown great potential in animal models of IS because of their high biocompatibility and ability to target multiple ischemic cascade signaling pathways, although low bioavailability is an issue that limits the applications of several polyphenols. Here, we review the pathophysiological changes following cerebral ischemia and summarize the research progress regarding the applications of polyphenolic compounds in the treatment of IS over the past 5 years. Furthermore, we discuss several potential strategies for improving the bioavailability of polyphenolic compounds as well as some essential issues that remain to be addressed for the translation of the related therapies to the clinic.

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Protocatechuic Acid Prevents Early Hour Ischemic Reperfusion Brain Damage by Restoring Imbalance of Neuronal Cell Death and Survival Proteins

Cited by 14 publications

References 45 publications

Korean Red Pine (Pinus densiflora) Bark Extract Attenuates Aβ-Induced Cognitive Impairment by Regulating Cholinergic Dysfunction and Neuroinflammation

Korean Red Pine (Pinus densiflora) Bark Extract Attenuates Aβ-Induced Cognitive Impairment by Regulating Cholinergic Dysfunction and Neuroinflammation

A dietary polyphenol metabolite alters CA1 excitability ex vivo and mildly affects cortico-hippocampal field potential generators in anesthetized animals

Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights

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