Prothrombotic Risk Factors in Children with Spontaneous Venous Thrombosis and Their Asymptomatic Parents

Lipoprotein (a) and Venous Thromboembolism in Adults: A Meta-Analysis

“…The contrasting results of the available studies on Lp(a) and venous thromboembolism can be explained by several issues. Half of the studies available in the literature have been conducted among children, [15][16][17][18][19][20][21][22][23][24][25][26] and most of the studies involving adults have investigated less than a hundred cases. [28][29][30] In addition, some studies are old and contain scarce and limited information regarding the diagnosis of venous thromboembolism.…”

“…Our search strategy yielded 24 reports [8][9][10][11][12][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] ; of them, 12 were excluded on the basis of title/abstract because they studied venous thrombosis in children. [15][16][17][18][19][20][21][22][23][24][25][26] Of the remaining 12 articles, one was excluded because it did not report Lp(a) levels but only apoLipoprotein (a) concentrations, 27 and another study was eliminated because it was, as a matter of fact, a family study that studied the co-segregation of thrombophilic disorders in factor V Leiden carriers. 31 Among the 10 case-control studies selected to be included in the meta-analysis, however, 3 potentially eligible studies 9,32,33 were finally excluded because the authors were not able, upon specific request, to collect the exact number of subjects with Lp(a) levels above the con-…”

Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology

“…However, in a study including 109,169 individuals from the Copenhagen City Heart Study and the Copenhagen General Population study combined, we found that high Lp(a) concentrations of venous thromboembolism, with conflicting results (232)(233)(234)(235)(236)(237)(238)(239)(240)(241)(242).…”

Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-up

“…We have previously shown that the factor V 1691GϾA (Leiden) mutation and further hereditary prothrombotic risk factors are strong determinants of thromboembolic complications in pediatric patients. [9][10][11][12][13][14] However, the role of these risk factors in the pathogenesis of neonatal renal venous thrombosis is not clear so far. Moreover, the published studies on this disease are sparse, and follow-up data on the functional outcome after neonatal RVT in larger numbers of patients are lacking.…”