Prothrombin Time and Activated Partial Thromboplastin Time Can Be Performed on the First Tube

Gottfried, Eugene L.; Adachi, Mitchell

doi:10.1093/ajcp/107.6.681

Cited by 22 publications

(19 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ten patients (29.4%) died within the 28 days after admission. The activated partial thromboplastin time (aPTT) and prothrombin time (PT) were determined as described (16). aPTT is expressed as the ratio of the scored value to a reference value.…”

Section: Methodsmentioning

confidence: 99%

High levels of catalytic antibodies correlate with favorable outcome in sepsis

Lacroix‐Desmazes

Bayry

Kaveri

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

110

102

View full text Add to dashboard Cite

Sepsis is the leading cause of death in intensive care units and results from a deleterious systemic host response to infection. Although initially perceived as potentially deleterious, catalytic antibodies have been proposed to participate in removal of metabolic wastes and protection against infection. Here we show that the presence in plasma of IgG endowed with serine protease-like hydrolytic activity strongly correlates with survival from sepsis. Variances of catalytic rates of IgG were greater in the case of patients with severe sepsis than healthy donors (P < 0.001), indicating that sepsis is associated with alterations in plasma levels of hydrolytic IgG. The catalytic rates of IgG from patients who survived were significantly greater than those of IgG from deceased patients (P < 0.05). The cumulative rate of survival was higher among patients exhibiting high rates of IgG-mediated hydrolysis as compared with patients with low hydrolytic rates (P < 0.05). An inverse correlation was also observed between the markers of severity of disseminated intravascular coagulation and rates of hydrolysis of patients' IgG. Furthermore, IgG from three surviving patients hydrolyzed factor VIII, one of which also hydrolyzed factor IX, suggesting that, in some patients, catalytic IgG may participate in the control of disseminated microvascular thrombosis. Our observations provide the first evidence that hydrolytic antibodies might play a role in recovery from a disease.

show abstract

Section: Methodsmentioning

confidence: 99%

High levels of catalytic antibodies correlate with favorable outcome in sepsis

Lacroix‐Desmazes

Bayry

Kaveri

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

110

102

View full text Add to dashboard Cite

show abstract

“…11,12 There are also a few studies on the effects of tube filling order on the routine coagulation parameters, including PT and APTT. [13][14][15][16][17] To the best of the authors' knowledge, there are no studies on the possible effects of tube filling order on specific coagulation parameters; therefore, the authors decided to conduct a study on the possible effects of this everyday practice on coagulation testing.…”

Section: Discussionmentioning

confidence: 99%

Effect of Tube Filling Order on Specific Coagulation Parameters in Healthy Subjects

Serin

Buğdaycı

2007

Laboratory Medicine

View full text Add to dashboard Cite

show abstract

“…A question often asked is should the first draw of blood be discarded. Studies by Yawn et al [7], Gottfried and Adachi [8], Adcock et al [9] and Brigden et al [10], showed that no statistical differences occurred for prothrombin time (PT), International Normalised Ratio (INR) and/or activated partial thromboplastin time (APTT) between a first and second draw tube. NCCLS guideline H21-A4 [11] indicates that it is acceptable practice to use the first draw tube if only PT, International Normalised Ratio (INR) or APTT are requested but for other coagulation tests there are no current published data to suggest that this practice is unnecessary.…”

Section: Abstract: Pre-analytical Variables Aptt Coagulation Analysesmentioning

confidence: 99%

Considerations in the laboratory assessment of haemostasis

2010

View full text Add to dashboard Cite

Summary. This review outlines a number of key issues when performing laboratory testing of homeostasis. The effect pre-analytical variables have on the reliability and consistency of screening tests is often forgotten due to a lack of understanding and awareness. This can be improved through educating healthcare professionals who are involved in taking blood for assessment. Recent advances in coagulation testing have not enabled laboratories to replace the Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) screening tests with more advanced assays and they continue to play an important role with the advantage of being easily automated. However, there are many analysers on the market, each with varying sensitivity to coagulation defects and it is important to keep this in mind when interpreting results.

show abstract

Prothrombin Time and Activated Partial Thromboplastin Time Can Be Performed on the First Tube

Abstract: P r o t h r o m b i n T i m e a n d A c t i v a t e d P a r t i a l T h r o m b o p l a s t i n T i m e C a n B e P e r f o r m e d o n t h e F i r s t T u b eEUGENE L. GOTTFRIED, MD, AND MITCHELL M. ADACHI, MD

Cited by 22 publications

References 2 publications

High levels of catalytic antibodies correlate with favorable outcome in sepsis

High levels of catalytic antibodies correlate with favorable outcome in sepsis

Effect of Tube Filling Order on Specific Coagulation Parameters in Healthy Subjects

Considerations in the laboratory assessment of haemostasis

Contact Info

Product

Resources

About