Proteus and coliform meningoencephalitis in neonates

Bacterial infection in the fetus and newborn.

“…Skin sepsis ranging from minute pustules to severe exfoliation may be caused by staphylococcal infection (Lee et al, 1952); while indurated erythematous rashes have been reported with some ofthe 'water bug' infections (Foley et al, 1961), and necrotic lesions with Pseudomonas aeruginosa. A peculiar foul smelling purple-coloured necrosis of brain tissue has been reported with enterobacterial infection (Cussen and Ryan, 1967;Shortland-Webb, 1968), with intense underlying vasculitis and infarction.…”

Cerebral Abscess Complicating Proteus mirabilis Meningitis in a Newborn Infant

“…While most reported cases of brain abscess resulting from Proteus meningitis occurred in patients who displayed neurologic abnormalities, which led to further neuroradiologic investigation, [5][6][7]9 our patient was found to have an asymptomatic intracranial abscess. Because the patient did not have any focal neurologic signs, we did not suspect any intracranial complications.…”

Pathophysiology of Citrobacter diversus neonatal meningitis: comparative studies in an infant mouse model

“…Results in the model do not correlate with the clinical source of the strain (i.e., whether a strain was isolated from a patient with meningitis), further suggesting that occurrence of illness in human infants is dependent on factors other than virulence of the organism after CNS inoculation. However, the model does appear to be of value in assessing pathophysiologic mechanisms involved in C. diversus CNS infections and may help to provide some understanding of why this and other gram-negative organisms (29,33) cause such devastating brain lesions in human neonates.…”