Proteopedia entry: Structure of complex membrane proteins solved using cryo‐electron microscopy

Proteopedia entry: Structure of complex membrane proteins solved using cryo‐electron microscopy

“…Proteopedia resources published recently in this journal. 1 Membrane-bound complexes are central to biochemistry classroom discussions of topics such as signal transduction, central metabolism, oxidative phosphorylation, and transmembrane protein structure. These Proteopedia pages also provide an introduction to the methodology and expand the importance of cryo-EM, as cryo-EM has facilitated the rapid structure determination of large protein complexes previously intractable by traditional methods.…”

“…These Proteopedia pages were constructed collaboratively by undergraduates in an upper-level biochemistry course. 1 Structure-function stories contained in the Proteopedia pages include the reductive mechanism of multiple bacterial bd oxidases, which shuttle protons and oxygen toward three catalytic hemes to perform the final reduction of molecular oxygen to water (Figure 1A). Large conformational changes are shown to control signal transduction through the insulin receptor, where new structural states and insulin-binding sites were observed by cryo-EM (Figure 1B).…”