Proteomics of pseudoexfoliation materials in the anterior eye segment

Morris, Jada; Myer, Ciara; Cornet, Tara; Junk, Anna K.; Lee, Ray-Kuang; Bhattacharya, Sanjoy K.

doi:10.1016/bs.apcsb.2021.03.004

Cited by 8 publications

(13 citation statements)

References 31 publications

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“…17 PEX proteomic studies have outlined the pathways in which genes, proteins and the environment influence the development of PEX. 20…”

Section: Discussionmentioning

confidence: 99%

“…17 PEX proteomic studies have outlined the pathways in which genes, proteins and the environment influence the development of PEX. 20 Lipidomic studies previously published have focused on sphingolipids, phospholipids, cholesterol, and glycosphingolipids of glaucomatous tissues (i.e., POAG) and the AH. [21][22][23][24] In this study, we expanded our analysis to include PEX, PEXG, POAG and controls with the inclusion of additional lipids like cholesterol esters, TGs, diacylglycerols, and ceramides.…”

Section: Discussionmentioning

confidence: 99%

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Analyses of pseudoexfoliation aqueous humor lipidome

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“…17 PEX proteomic studies have outlined the pathways in which genes, proteins and the environment influence the development of PEX. 20…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analyses of pseudoexfoliation aqueous humor lipidome

et al. 2022

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“…Interestingly, in exfoliation deposits studies showed elevated levels of CLU which colocalized with exfoliation fibrils 34 . In addition, CLU has also been found colocalized with another important protein of PEX deposits, LOXL1 35 . From a genetic point of view PEXS is highly associated with LOXL1, since LOX and LOX‐like family enzymes catalyze the polymerization of tropoelastin and the production of ELN that in turn leads to the formation of elastic fibers.…”

Section: The Role Of Ecm In Pexsmentioning

confidence: 97%

“…34 In addition, CLU has also been found colocalized with another important protein of PEX deposits, LOXL1. 35 From a genetic point of view PEXS is highly associated with LOXL1, since LOX and LOX-like family enzymes catalyze the polymerization of tropoelastin and the production of ELN that in turn leads to the formation of elastic fibers. LOXL1 stabilizes and supports ELN regulates its promoter.…”

Section: The Role Of Ecm In Pexsmentioning

confidence: 99%

Pseudoexfoliation syndrome: The critical role of the extracellular matrix in pathogenesis and treatment

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Pseudoexfoliation syndrome (PEXS) is an age-related condition manifesting mainly in ocular tissues. PEXS is manifested through excess aggregation of fibrillary extracellular material at the anterior part of the eye that consists of a plethora of biomolecules, such as different proteoglycans (PGs) and glycosaminoglycans. PEXS is often linked to increased intraocular pressure, and can also lead to pseudoexfoliation glaucoma with very poor prognosis. Various stimuli are known to affect PEXS, including oxidation stress (OS), UV radiation and osmotic pressure. OS, is prominently involved on the progression of the syndrome as it promotes fibrogenesis, possibly via the induction of transforming growth factor-β (TGF-β) and other biomolecular effectors. In addition, PEXS initiation is tightly connected with the dysregulation of extracellular matrix (ECM) homeostasis since aberrant expression of ECM molecules is linked to both the accumulation and low degradation of pseudoexfoliation material. This article aims at uncovering the crucial role of various ECM effectors such as lysyl oxidase-like proteins, matrix metalloproteinases, and TGF-β1, as well as the biochemical pathways involved in the development and the progression of the PEXS.

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“…Notably, the expression levels of CLU have been correlated with both physiological and pathological processes, including regulation of lipid transport, apoptosis, cell-cell and cell-matrix interactions, and OS. Interestingly, elevated levels of CLU are found in PEXM deposits, which are colocalised with exfoliation fibrils and LOXL1 ( 59 , 60 ). Furthermore, the expression of CLU decreases in PEX individuals, which could be responsible for reduced chaperone function and deposition of PEXM in the anterior segment of the eye ( 61 ).…”

Section: Pathogenesis Of Pexsmentioning

confidence: 99%

Emerging roles of oxidative stress in the pathogenesis of pseudoexfoliation syndrome (Review)

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Pseudoexfoliation syndrome (PEXS) is a systemic disease caused by defects in the extracellular matrix (ECM) remodelling process leading to the chronic deposition of extracellular, fibrillary, white flaky pseudoexfoliation material (PEXM) throughout the body. Specifically, PEXM deposits on the lens capsule cause open-angle glaucoma, cataracts and blindness in patients with PEXS. Several gene single nucleotide polymorphisms are linked to the development of PEXS in humans, including lysyl oxidase-like 1 gene, clusterin and fibulin-5. The exact reason for the PEXM generation and its resulting pathogenesis is not well understood. However, defective ECM remodelling and oxidative stress (OS) have been hypothesized as significant events leading to the PEXM. Specifically, the link between OS and PEXS has been well studied, although the investigation is still ongoing. The present review explored recent advances in various aspects of PEXS and the involvement of OS in the eye for PEXS development.

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Proteomics of pseudoexfoliation materials in the anterior eye segment

Cited by 8 publications

References 31 publications

Analyses of pseudoexfoliation aqueous humor lipidome

Analyses of pseudoexfoliation aqueous humor lipidome

Pseudoexfoliation syndrome: The critical role of the extracellular matrix in pathogenesis and treatment

Emerging roles of oxidative stress in the pathogenesis of pseudoexfoliation syndrome (Review)

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