Emerging roles of oxidative stress in the pathogenesis of pseudoexfoliation syndrome (Review)

Mastronikolis, Stylianos; Pagkalou, Marina; Plotas, Panagiotis; Kagkelaris, Konstantinos; Georgakopoulos, Constantinos D.

doi:10.3892/etm.2022.11539

Cited by 8 publications

(5 citation statements)

References 146 publications

(157 reference statements)

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“…In addition, cataract is a common complication of uveitis and may be caused by inflammation [ 16 , 19 , 20 ]. Pseudoexfoliation syndrome (PEXS) is a disorder characterized by the chronic build-up of white flaky material called pseudoexfoliation material (PEXM) in the extracellular matrix (ECM) throughout the body [ 21 ]. It has been studied that the formation of PEXS is linked to oxidative stress and inflammation [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

Shu,

Liu,

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

Shu,

Liu,

et al. 2024

Heliyon

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“…Each is a defined clinical entity with the specific genes involved distinctly. PEXS is a systemic disease caused by defects in the extracellular matrix (ECM) [95]. The production and progressive accumulation of abnormal fibrillar extracellular material in ocular and extra tissues characterize it.…”

Section: Oxidative Stress In the Anterior Chambermentioning

confidence: 99%

“…The production and progressive accumulation of abnormal fibrillar extracellular material in ocular and extra tissues characterize it. Recent studies described that defective ECM remodelling and oxidative stress had been hypothesized as significant events leading to PEXS [95]. The link between OS and PEXS was investigated.…”

Section: Oxidative Stress In the Anterior Chambermentioning

confidence: 99%

Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment

et al. 2023

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The eye is a metabolically active structure, constantly exposed to solar radiations making its structure vulnerable to the high burden of reactive oxygen species (ROS), presenting many molecular interactions. The biomolecular cascade modification is caused especially in diseases of the ocular surface, cornea, conjunctiva, uvea, and lens. In fact, the injury in the anterior segment of the eye takes its origin from the perturbation of the pro-oxidant/antioxidant balance and leads to increased oxidative damage, especially when the first line of antioxidant defence weakens with age. Furthermore, oxidative stress is related to mitochondrial dysfunction, DNA damage, lipid peroxidation, protein modification, apoptosis, and inflammation, which are involved in anterior ocular disease progression such as dry eye, keratoconus, uveitis, and cataract. The different pathologies are interconnected through various mechanisms such as inflammation, oxidative stress making the diagnostics more relevant in early stages. The end point of the molecular pathway is the release of different antioxidant biomarkers offering the potential of predictive diagnostics of the pathology. In this review, we have analysed the oxidative stress and inflammatory processes in the front of the eye to provide a better understanding of the pathomechanism, the importance of biomarkers for the diagnosis of eye diseases, and the recent treatment of anterior ocular diseases.

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“…The fibrillar material, possibly the proteoglycan/glycoprotein complex, has an undetermined composition [ 6 ]. Ischemia, hypoxia, oxidative stress, and chronic inflammation are additional pathogenic factors [ 5 , 7 , 8 ]. However, whether the accumulation of pseudoexfoliative material results from excessive production or inefficient degradation has not been determined.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Risk Factors Predicting Cataract Surgery Complications in Patients with Pseudoexfoliation Syndrome: A Systematic Review

Preoteasa,

Baltă,

Baltă

2024

JCM

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(1) Background: The present review aims to identify risk factors with predictive value for differentiating between pseudoexfoliation patients at risk of developing intra- or postoperative complications and those without operative risk during cataract surgery. (2) Methods: The review protocol was registered at PROSPERO, registration no. CRD42023417721. The following databases were searched for studies between 2000 and 2023: PubMed/Medline, Scopus, Springer, Science Direct, Web of Science, Cochrane Database of Systematic Reviews, TRIP database, LILACS, Clinical Trials, and reference lists of articles. We included analytical studies of any design examining cataract surgery complications in pseudoexfoliation patients across two population groups, one who underwent uneventful cataract surgery and the other who experienced intra- or postoperative complications. The paper will follow PRISMA 2020 criteria for reporting. Effect measure was assessed using odds ratios (ORs) and corresponding 95% confidence interval (CI) for qualitative variables and means with their respective standard deviation (SD) for quantitative variables. The risk of bias was assessed using the method presented in the Cochrane Handbook for Systematic Reviews. The GRADE scale was used for quality of evidence and certainty. (3) Results: The initial search of published and gray literature databases retrieved 1435 articles, six of which were included in this report. A total of 156 intra- or postoperative incidents were reported in 999 eyes with pseudoexfoliation. The identified predictive factors were a shallow anterior chamber, cataract grade, neutrophil-to-lymphocyte ratio, preoperative intraocular pressure, and symmetry of the exfoliation material. Limitations include heterogeneity of data and limited number of studies identified in our search. (4) Conclusions: These findings suggest the potential to refine risk stratification protocols in clinical settings and assist surgeons in personalized decision-making among individuals with pseudoexfoliation syndrome.

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Emerging roles of oxidative stress in the pathogenesis of pseudoexfoliation syndrome (Review)

Cited by 8 publications

References 146 publications

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment

Investigation of Risk Factors Predicting Cataract Surgery Complications in Patients with Pseudoexfoliation Syndrome: A Systematic Review

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