Proteomics in Veterinary Medicine

Ceciliani, Fabrizio; Eckersall, David; Burchmore, Richard; Lecchi, Cristina

doi:10.1177/0300985813502819

Cited by 63 publications

(33 citation statements)

References 123 publications

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“…Proteomics analysis is one of these tools, based on the quantification of changes in the protein composition of udder secretions, particularly those proteins involved in immunological events (ECKERSALL 2000;ECKERSALL 2004;CECILIANI et al, 2013;FUNMILOLA et al, 2015).…”

Section: Somatic Cell Counts (Scc)mentioning

confidence: 99%

Bovine mastitis: a persistent and evolving problem requiring novel approaches for its control - a review

et al. 2018

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M. SAMARDŽIJA: Bovine mastitis: a persistent and evolving problem requiring novel approaches for its control -a review. Vet. arhiv 88, 535-557, 2018. ABSTRACT Mastitis in dairy cows is the inflammation of the mammary gland, and is the most important cause of economic losses in the modern dairy industry. Bovine mastitis is often infectious and can be caused by some 150 microbial species. The environment of the dairy cow is heavily colonized by microbiota, while milk is an ideal medium for propagation of the bacteria and causative agents. Staphylococcus aureus is the most common pathogen isolated from the mammary gland capable of causing health disorders in humans. Milk from an infected mammary gland has a different chemical composition compared to milk from healthy cows. Certain differences, such as protein components specific to inflamed tissue, are currently being considered in 2018 M. Benić et al.: Bovine mastitis: a persistent and evolving problem requiring novel approaches for its control the development of diagnostic tools for mastitis. The known risk factors for mastitis can result in mastitis at the quarter, cow and herd levels. Mastitis treatment includes both preventive and therapy measures, and is primarily based on the use of antibiotics. Recent approaches to mastitis therapy have been focused on the design and use of natural therapeutics, such as zeolites, ozone and propolis, that could serve as alternatives to antibiotics.

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Section: Somatic Cell Counts (Scc)mentioning

confidence: 99%

Bovine mastitis: a persistent and evolving problem requiring novel approaches for its control - a review

et al. 2018

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“…With the latest technological advances, protein identi cations from different samples by proteomic analysis can provide new details in the discrimination between diseased and healthy status. Modern platelet proteomic studies can reveal quantitative and posttransitional changes in proteins, protein-protein interactions and protein localisations (10). Thus, platelet proteomics studies allow the characterization and elaboration of the basic biological, molecular and cellular functions of diseased and healthy conditions (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Platelet Proteome Changes in Dogs with Chronic Heart Failure

Levent

Kocatürk

Akgun

et al. 2020

Preprint

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Background: Platelets play a central role in the development of cardiovascular diseases and changes in their proteins are involved in the pathophysiology of heart diseases in humans. There is lack of knowledge about the possible role of platelets in chronic heart failure (CHF) in dogs. Thus, this study aimed to investigate the changes in global platelet proteomes in dogs with CHF, to clarify the possible role of platelets in the physiopathology of this disease. Healthy-dogs (n=10) and dogs with CHF due to myxomatous mitral valve degeneration (n=10) were used. Blood samples were collected into tubes with acid-citrate-dextrose, and platelet-pellets were obtained by centrifuge and washing steps. Platelet-proteomes were identified using LC-MS based label-free differential proteome expression analysis method and matched according to protein database for Canis lupus familiaris. Results: Totally 107 different proteins were identified in the platelets of the dogs being 4 out of them were significantly up-regulated and 6 down-regulated in the CHF dogs. Guanine-nucleotide-binding protein, apolipoproteins (A-II and C-III) and clusterin levels increased, but CXC-motif-chemokine-10, cytochrome-C-oxidase-subunit-2, cathepsin-D, serine/threonine-protein-phosphatase-PP1-gamma-catalytic-subunit, creatine-kinase-B-type and myotrophin levels decreased in the CHF dogs. These proteins are associated with several molecular functions, biological processes, signaling systems and immune-inflammatory responses.Conclusion: This study describes by first time the changes in the protein composition in platelets of dogs with CHF. Our findings provide a resource for increase the knowledge about the proteome of canine platelets and their roles in CHF and could be a tool for further investigations about the prevention and treatment of this disease.

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“…Both proteomics and metabolomics have evolved as the functional continuation of transcriptomics in less than two decades, and have developed rapidly, due to improvements in technology and bioinformatics tools. General reviews about the application of proteomics and metabolomics to livestock science were published earlier [10][11][12]. Both proteomics and metabolomics involve the resolution of a complex mixture of compounds into components that can then be identified and characterized.…”

Section: Introductionmentioning

confidence: 99%

Proteomics and metabolomics characterizing the pathophysiology of adaptive reactions to the metabolic challenges during the transition from late pregnancy to early lactation in dairy cows

Ceciliani

Lecchi

Urh

et al. 2018

Journal of Proteomics

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For high-yielding dairy cows there are several "occupational diseases" that occur mainly during the metabolic challenges related to the transition from pregnancy to lactation. Such diseases and their sequelae form a major concern for dairy production, and often lead to early culling of animals. Beside the economical perspective, metabolic stress may severely influence animal welfare. There is a multitude of studies about the metabolic backgrounds of such so called production diseases like ketosis, fatty liver, or hypocalcaemia, although the investigations aiming to assess the complexity of the pathophysiological reactions are largely focused on gene expression, i.e. transcriptomics. For extending the knowledge towards the proteome and the metabolome, the respective technologies are of increasing importance and can provide an overall view of how dairy cows react to metabolic stress, which is needed for an in-depth understanding of the molecular mechanisms of the related diseases. We herein review the current findings from studies applying proteomics and metabolomics to transition-related diseases, including fatty liver, ketosis, endometritis, hypocalcaemia and laminitis. For each disease, a brief overview of the up to date knowledge about its pathogenesis is provided, followed by an insight into the most recent achievements on the proteome and metabolome of tissues and biological fluids, such as blood serum and urine, highlighting potential biomarkers. We believe that this review would help readers to be become more familiar with the recent progresses of molecular background of transition-related diseases thus encouraging research in this field.

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Proteomics in Veterinary Medicine

Cited by 63 publications

References 123 publications

Bovine mastitis: a persistent and evolving problem requiring novel approaches for its control - a review

Bovine mastitis: a persistent and evolving problem requiring novel approaches for its control - a review

Platelet Proteome Changes in Dogs with Chronic Heart Failure

Proteomics and metabolomics characterizing the pathophysiology of adaptive reactions to the metabolic challenges during the transition from late pregnancy to early lactation in dairy cows

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