Proteomics combines morphological, physiological and biochemical attributes to unravel the survival strategy of Anabaena sp. PCC7120 under arsenic stress

Pandey, Sarita; Rai, Rashmi; Chand, Lal

doi:10.1016/j.jprot.2011.10.011

Cited by 145 publications

(98 citation statements)

References 120 publications

(140 reference statements)

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“…Additionally, proteomics in conjunction with morphological, physiological, and biochemical analyses have been employed to unravel for the first time survival strategies of the diazotrophic cyanobacterium anabaena sp. PCC7120 under arsenic stress [44]. These studies together with other published studies on arsenic toxicity typically reflect many common interests, approaches, and potential problems that were found in the OMICS analysis of single environmental chemicals.…”

Section: Environmental Omics Of Single Chemicals Vs Chemical Mixturementioning

confidence: 91%

Environmental OMICS: Current Status and Future Directions

Ge¹,

Wang²,

Chiu³

et al. 2013

JIOMICS

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Objectives: Applications of OMICS to high throughput studies of changes of genes, RNAs, proteins, metabolites, and their associated functions in cells or organisms exposed to environmental chemicals has led to the emergence of a very active research field: environmental OM-ICS. This developing field holds an important key for improving the scientific basis for understanding the potential impacts of environmental chemicals on both health and the environment. Here we describe the state of environmental OMICS with an emphasis on its recent accomplishments and its problems and potential solutions to facilitate the incorporation of OMICS into mainstream environmental and health research.Data sources: We reviewed relevant and recently published studies on the applicability and usefulness of OMICS technologies to the identification of toxicity pathways, mechanisms, and biomarkers of environmental chemicals for environmental and health risk monitoring and assessment, including recent presentations and discussions on these issues at The First International Conference on Environmental OMICS (ICEO), held in Guangzhou, China during November 8-12, 2011. This paper summarizes our review.Synthesis: Environmental OMICS aims to take advantage of powerful genomics, transcriptomics, proteomics, and metabolomics tools to identify novel toxicity pathways/signatures/biomarkers so as to better understand toxicity mechanisms/modes of action, to identify/ categorize/prioritize/screen environmental chemicals, and to monitor and predict the risks associated with exposure to environmental chemicals on human health and the environment. To improve the field, some lessons learned from previous studies need to be summarized, a research agenda and guidelines for future studies need to be established, and a focus for the field needs to be developed.Conclusions: OMICS technologies for identification of RNA, protein, and metabolic profiles and endpoints have already significantly improved our understanding of how environmental chemicals affect our ecosystem and human health. OMICS breakthroughs are empowering the fields of environmental toxicology, chemical toxicity characterization, and health risk assessment. However, environmental OMICS is still in the data generation and collection stage. Important data gaps in linking and/or integrating toxicity data with OMICS endpoints/profiles need to be filled to enable understanding of the potential impacts of chemicals on human health and the environment. It is expected that future environmental OMICS will focus more on real environmental issues and challenges such as the characterization of chemical mixture toxicity, the identification of environmental and health biomarkers, and the development of innovative environmental OMICS approaches and assays. These innovative approaches and assays will inform chemical toxicity testing and prediction, ecological and health risk monitoring and assessment, and natural resource utilization in ways that maintain human health and protects the environment in a...

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Section: Environmental Omics Of Single Chemicals Vs Chemical Mixturementioning

confidence: 91%

Environmental OMICS: Current Status and Future Directions

Ge¹,

Wang²,

Chiu³

et al. 2013

JIOMICS

View full text Add to dashboard Cite

show abstract

“…Similarly, arsenic is also reported to inhibit chlorophyll biosynthesis, photosynthetic pigments and Rubisco and generates oxidative stress through ROS generation thus damaging lipids, proteins and nucleic acids (Tantry et al, 2015;Srivastava et al, 2009;Pandey et al, 2012 Present study is important in the sense that the results would provide important information regarding the cyanobacteria's ability to tolerate arsenic and nickel.…”

Section: Introductionmentioning

confidence: 88%

Comparative assessment of Ni and As(III) mediated alterations in diazotrophic cyanobacteria, Anabaena doliolum and Anabaena sp. PCC7120

Prajapati¹,

Yadav²,

Atri³

2017

Afr. J. Microbiol. Res.

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The comparative effects of nickel (Ni 2+ ) and arsenite (As(III)) on two diazotrophic cyanobacterial species were investigated in terms of photosynthetic attributes. Both metals demonstrated inhibitory effects on growth, pigments (chl a and phycocyanin) and photosystem II (PS II) photochemistry. However As(III) exerted severe effects as compared to Ni reflected by (1) reduced growth (2) significant inhibition of chl a and phycocyanin, (3) reduction in maximum photochemical efficiency of PSII and (4) depleted plastoquinone pool, thus suggesting it as more toxic. Moreover, comparative analysis of two species also demonstrated interspecies variation in terms of stress adaptive strategies reflected through higher sensitivity of Anabaena doliolum over Anabaena PCC7120. Thus the study recommends application of A. PCC7120 as biofertilizer in Ni and As(III) contaminated paddy fields.

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“…Proteomics in combination with morphological, physiological and biochemical studies have shed light on the survival of the nitrogen fixing cyanobacterium Anabaena sp. PCC7120 under arsenic stress [57]. Proteomic analyses revealed that some enzymes such as phosphoglycerate kinase, fructose bisphosphate aldolase II, fructose 1,6 bisphosphatase, transketolase, and ATP synthase were down-regulated on day 1 but then significantly recovered on the 15th day.…”

Section: Stress Responses In Prokaryotic Microorganismsmentioning

confidence: 99%

Proteomic Studies of the Effects of Different Stress Conditions on Central Carbon Metabolism in Microorganisms

2015

J Proteomics Bioinform

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Proteomics combines morphological, physiological and biochemical attributes to unravel the survival strategy of Anabaena sp. PCC7120 under arsenic stress

Cited by 145 publications

References 120 publications

Environmental OMICS: Current Status and Future Directions

Environmental OMICS: Current Status and Future Directions

Comparative assessment of Ni and As(III) mediated alterations in diazotrophic cyanobacteria, Anabaena doliolum and Anabaena sp. PCC7120

Proteomic Studies of the Effects of Different Stress Conditions on Central Carbon Metabolism in Microorganisms

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