Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia

Sharma, Narendra Kumar; Tashima, Alexandre Keiji; Brunialti, Milena Karina Coló; Ferreira, Éden Ramalho; Torquato, Ricardo J.S.; Mortara, Renato Arruda; Machado, Flávia Ribeiro; Assunção, Murillo Santucci César de; Rigato, Otelo; Salomão, Reinaldo

doi:10.1038/s41598-017-15755-1

Cited by 54 publications

(75 citation statements)

References 54 publications

(53 reference statements)

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“…Previous studies have reported that lipid metabolism impairment may be involved in the pathogenesis of sepsis secondary to pneumonia and in uenza [8][9][10]. Similarly, recent studies observed dyslipidemia in patients infected with SARS-CoV-2, using MS analysis [6,7] and routine laboratory lipid tests [11], indicating that blood lipid might involve in the pathogenesis of COVID-19.…”

Section: Discussionmentioning

confidence: 89%

A Preliminary Study on Blood Lipid Profile in Patients with COVID-19

Zhu

Yang

Fan

et al. 2020

Preprint

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Background: Recently, dyslipidemia was observed in the patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the blood lipid profile in the patients with COVID-19, and explore their predictive value for COVID-19 severity.Methods: 142 consecutive patients with COVID-19 admitted to HwaMei Hospital, University of Chinese Academy of Sciences, from January 23 to April 20, 2020, and 77 age- and gender-matched healthy subjects were included in this retrospective study. The blood lipid profile in the patients with COVID-19 were investigated, and their predictive values for COVID-19 severity were analysed.Results: There were 125 and 17 cases in the non-severe and severe group, respectively. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein A1 (ApoA1) gradually decreased across healthy controls, non-severe group, and severe group. ApoA1 was recognized as an independent risk factor for COVID-19 severity，and had the highest area under the receiver operator characteristic curve (AUC) among all the single markers (AUC: 0.896, 95% CI: 0.834-0.941). Moreover, the risk model established using ApoA1 and IL-6 enhanced the prediction efficiency (AUC: 0.977, 95% CI: 0.932-0.995). Conclusion: The blood lipid profile in the patients with COVID-19 is quite abnormal from healthy subjects, especially in the severe cases. Serum ApoA1 might serve as a good indictor to reflect the severity of COVID-19.

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Section: Discussionmentioning

confidence: 89%

A Preliminary Study on Blood Lipid Profile in Patients with COVID-19

Zhu

Yang

Fan

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…Among the alterations in the concentrations of the proteins found were those associated to cytoskeletal organization, cell movement, energy metabolism, inflammation, coagulation and bleeding. The results also showed negative regulation of apolipoproteins like ApoA2, ApoA4, ApoC1, ApoC2, ApoC3, Apod and Pon1 [48].…”

Section: Biomarkers In Sepsismentioning

confidence: 79%

Lipidomic profile and candidate biomarkers in septic patients

2020

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Sepsis is a severe disease with a high mortality rate. Identification and treatment in the initial hours of the disease improve outcomes. Some biomarkers like procalcitonin and C-reactive protein are used for diagnosis and to access sepsis prognosis and they can help in clinical decision-making, but none has sufficient specificity or sensitivity to be routinely employed in clinical practice. This review seeks to evaluate lipid metabolism alterations in patients with sepsis and the possibility of using the respective metabolites as biomarkers of the disease. A search of the main electronic biomedical databases was conducted for the 20-year period ending in February 2020, focused on primary research articles on biomarkers in sepsis. The keywords included sepsis, septic shock, biomarker, metabolomic, lipidomic and lysophosphatidylcoline.. It concludes that altered lipid profiles, along with the progress of the disease should provide new insights, enabling a better understanding of the pathogenic mechanisms and making it possible to design new early diagnosis and therapeutic procedures for sepsis.

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“…Proteomic studies underlined the diversity of HDLassociated proteins in normal conditions [9]. HDL proteome is clearly modified during inflammatory conditions [81] and in particular in sepsis state [82]. Sharma et al evaluated the host proteome response in septic patients secondary to community-acquired pneumonia (CAP) [82].…”

Section: Hdl Function In Inflammatory Statementioning

confidence: 99%

“…HDL proteome is clearly modified during inflammatory conditions [81] and in particular in sepsis state [82]. Sharma et al evaluated the host proteome response in septic patients secondary to community-acquired pneumonia (CAP) [82]. This analysis has shown alteration in the cytoskeleton, cellular assembly, movement, lipid metabolism, and immune response in septic patients.…”

Section: Hdl Function In Inflammatory Statementioning

confidence: 99%

High-density lipoproteins during sepsis: from bench to bedside

et al. 2020

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High-density lipoproteins (HDLs) represent a family of particle characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport cholesterol from peripheral tissues back to the liver conferring them a cardioprotective function. HDLs also display pleiotropic properties including antioxidant, anti-apoptotic, antithrombotic, anti-inflammatory, or anti-infectious functions. Clinical data demonstrate that HDL cholesterol levels decrease rapidly during sepsis and that these low levels are correlated with morbi-mortality. Experimental studies emphasized notable structural and functional modifications of HDL particles in inflammatory states, including sepsis. Finally, HDL infusion in animal models of sepsis improved survival and provided a global endothelial protective effect. These clinical and experimental studies reinforce the potential of HDL therapy in human sepsis. In this review, we will detail the different effects of HDLs that may be relevant under inflammatory conditions and the lipoprotein changes during sepsis and we will discuss the potentiality of HDL therapy in sepsis.

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Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia

Cited by 54 publications

References 54 publications

A Preliminary Study on Blood Lipid Profile in Patients with COVID-19

A Preliminary Study on Blood Lipid Profile in Patients with COVID-19

Lipidomic profile and candidate biomarkers in septic patients

High-density lipoproteins during sepsis: from bench to bedside

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