A Preliminary Study on Blood Lipid Profile in Patients with COVID-19

Zhu, Zhe; Yang, Yayun; Fan, Limin; Ye, Shuyuan; Lou, Kehong; Hua, Xin; Huang, Zuoan; Shi, Qiaoyun; Gao, Guosheng

doi:10.21203/rs.3.rs-57301/v1

“…It is possible that due to passing the early course of the disease, in this study there was no decrease in HDL-C level in the severe form of the disease. About dyslipidemia in Covid-19 patients, some studies have reported a decrease in lipid pro les as the disease progresses [23,24]. Contrary to our study, in studies by Li et al and Wang et al, a decrease in HDL-C levels was observed in severe cases of the disease, and this factor was reported as a risk factor for disease severity [23,25].…”

Section: Discussioncontrasting

confidence: 99%

A Case-Control Study on Blood Lipid Profile in Patients with COVID-19

Changaripour

¹

,

Sarvazad

²

,

Barghi

³

et al. 2021

Preprint

0

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Background Dyslipidemia has been reported in patients with virus infections. This study was performed to evaluate the blood lipid profile in the patients with coronavirus disease 2019 (COVID-19), and exploring the underlying factors in its development and their predictive value for the severity of COVID-19.Methods In a case-control study, the lipid profile of patients with COVID-19 at the first admitted to two clinical centers in the west of Iran (July 2020 to Dec. 2020) and age- and gender-matched healthy people were explored. Three groups of controls, patients with the severe form of Covid-19 (admitted to the intensive care unit (ICU)), patients with Covid-19 with less intensity (outpatient admission), were defined for the subjects included in the study. The predictive values of different variables obtained from medical records for COVID-19 severity were analyzed.Results Generally, 48 outpatients and 49 ICU patients, including 70 men and 23 women with a mean age of 62.4±13.5 years, were included in the study. The control group consisted of 32 people, match sex and age with the patient groups. The mean triglyceride (TG) in the Covid-19 groups was higher than the control group, but there was no significant difference between them. The mean cholesterol in the patient groups was lower than the control group (p=0.001). The mean of low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) was significantly different in the patient groups; HDL-C in the ICU group was more than outpatient, and LDL-C in the outpatient group was more than ICU (P<0.05). LDL-C and HDL-C in the ICU group were less than the control group, but there was no statistically significant difference between the two mentioned groups. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group (P<0.001). Furthermore, LDL-C level was associated with disease severity (odds ratio (OR): 0.966, 95% confidence interval (CI): 0.944-0.989, P= 0.004).Conclusion Lipid profiles in Covid-19 patients have different faces from healthy individuals. In the severe form, the lipid status has a different profile from the less severe form of Covid-19 disease. LDL-C level can be used as an indicator to determine the severity of Covid-19 disease.

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“…It is possible that due to passing the early course of the disease, in this study there was no decrease in HDL-C level in the severe form of the disease. About dyslipidemia in Covid-19 patients, some studies have reported a decrease in lipid pro les as the disease progresses [23,24]. Contrary to our study, in studies by Li et al and Wang et al, a decrease in HDL-C levels was observed in severe cases of the disease, and this factor was reported as a risk factor for disease severity [23,25].…”

Section: Discussioncontrasting

confidence: 99%

A case-control Study on Blood Lipid Profile in Patients with COVID-19

Changaripour

¹

,

Sarvazad

²

,

Barghi

³

et al. 2021

Preprint

1

0

View full text Add to dashboard Cite

Background Dyslipidemia has been reported in patients with virus infections. This study was performed to evaluate the blood lipid profile in the patients with coronavirus disease 2019 (COVID-19), and exploring the underlying factors in its development and their predictive value for the severity of COVID-19.Methods In a case-control study, the lipid profile of patients with COVID-19 at the first admitted to two clinical centers in the west of Iran (July 2020 to Dec. 2020) and age- and gender-matched healthy people were explored. Three groups of controls, patients with the severe form of Covid-19 (admitted to the intensive care unit (ICU)), patients with Covid-19 with less intensity (outpatient admission), were defined for the subjects included in the study. The predictive values of different variables obtained from medical records for COVID-19 severity were analyzed.Results Generally, 48 outpatients and 49 ICU patients, including 70 men and 23 women with a mean age of 62.4±13.5 years, were included in the study. The control group consisted of 32 people, match sex and age with the patient groups. The mean triglyceride (TG) in the Covid-19 groups was higher than the control group, but there was no significant difference between them. The mean cholesterol in the patient groups was lower than the control group (p=0.001). The mean of low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) was significantly different in the patient groups; HDL-C in the ICU group was more than outpatient, and LDL-C in the outpatient group was more than ICU (P<0.05). LDL-C and HDL-C in the ICU group were less than the control group, but there was no statistically significant difference between the two mentioned groups. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group (P<0.001). Furthermore, LDL-C level was associated with disease severity (odds ratio (OR): 0.966, 95% confidence interval (CI): 0.944-0.989, P= 0.004).Conclusion Lipid profiles in Covid-19 patients have different faces from healthy individuals. In the severe form, the lipid status has a different profile from the less severe form of Covid-19 disease. LDL-C level can be used as an indicator to determine the severity of Covid-19 disease.

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Association between lipid profile and clinical outcomes in COVID-19 patients

Ochoa-Ramírez,

De la Herrán Arita,

Sanchez-Zazueta

et al. 2024

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0

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High-density lipoprotein cholesterol (HDL-c) removes cholesterol, an essential component in lipid rafts, and this cholesterol removal can regulate protein attachment to lipid rafts, modulating their functionality in the immune cell response. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can alter the lipid profile, there is little information on the role of HDL-c and other lipids in prognostic of the coronavirus disease 2019 (COVID-19) in Mexican population. This study aims to evaluate the predictive value of HDL-c and lipid profile on severity and survival of 102 patients infected with SARS-CoV-2 during the COVID-19 first wave. Our findings, derived from univariate and multivariate Cox proportional hazards regression models, highlighted age and hypertension as significant predictors of survival (HR = 1.04, p = 0.012; HR = 2.78, p = 0.027), while gender, diabetes, and obesity showed no significant impact. Triglycerides and HDL-c levels notably influenced mortality, with elevated triglycerides and lower HDL-c associated with higher mortality risk (p = 0.032). This study underscores the importance of lipid profiles alongside traditional risk factors in assessing COVID-19 risk and outcomes. It contributes to the understanding of COVID-19 patient management and emphasizes the need for further investigation into the role of dyslipidemia in influencing COVID-19 prognosis, potentially aiding in refined risk stratification and therapeutic strategies.

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A Preliminary Study on Blood Lipid Profile in Patients with COVID-19

Cited by 4 publications

References 22 publications

A Case-Control Study on Blood Lipid Profile in Patients with COVID-19

A Case-Control Study on Blood Lipid Profile in Patients with COVID-19

A case-control Study on Blood Lipid Profile in Patients with COVID-19

Association between lipid profile and clinical outcomes in COVID-19 patients

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