Proteomic Analysis Reveals that Odoroside A Triggers G2/M Arrest and Apoptosis in Colorectal Carcinoma Through ROS‐p53 Pathway

Chen, Yanyan; Wen, Shiyuan; Deng, Chun-Miao; Yin, Xinhua; Sun, Zhi; Jiang, Miaomiao; He, Qing‐Yu

doi:10.1002/pmic.201900092

Cited by 14 publications

(12 citation statements)

References 36 publications

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“…An increased understanding of the role of ROS shows that ROS are not only metabolic byproducts but also signaling molecules [7,8]. Excess ROS could activate several injury-producing pathways, such as the nuclear factor-kb (NF-κb) inflammatory and p53 apoptotic pathways [9,10]. The transcription factor and tumor suppressor p53 is closely related to DNA repair, cellular stress response, and cell cycle control [11,12].…”

Section: Introductionmentioning

confidence: 99%

ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis

Zhang

Song

et al. 2020

Disease Markers

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Aim. This study was aimed at identifying the role of zinc finger protein 143 (ZNF143) in gastric cancer (GC) progression. Methods. The impact of ZNF143 on the proliferation ability and apoptosis of GC cells was detected. The expression of ZNF143 and related targeted genes was determined using Western blot analysis. The reactive oxygen species (ROS) level of GC cells was examined using the ROS generation assay. The role of ZNF143 in the proliferation of GC cells in vivo was examined using tumor xenograft assay. Results. The ectopic overexpression of ZNF143 promoted the proliferation of GC cells, while its knockdown reduced the effect in vitro. The downregulation of ZNF143 facilitated cell apoptosis. ZNF143 decreased the ROS level in GC cells, resulting in the reduction of cell apoptosis. Transfection with p53 reversed the antiapoptotic effect of ZNF143, while pifithrin-α, a specific inhibitor of p53, reduced the apoptosis in ZNF143-knockdown GC cells. However, p53 had no influence on the ROS level in GC cells. p53 played a key role in inhibiting ROS generation in GC cells, thereby inhibiting apoptosis. The transplanted tumor weight and volume were higher in the ZNF143-overexpressed group than in the ZNF143-knockdown group in vivo. The expression of ZNF143 in the transplanted tumor correlated positively with the proliferation index of Ki67 and negatively with the expression of p53 and cell apoptosis. Conclusion. ZNF143, as a tumor oncogene, promoted the proliferation of GC cells both in vitro and in vivo, indicating that ZNF143 might function as a novel target for GC therapy.

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Section: Introductionmentioning

confidence: 99%

ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis

Zhang

Song

et al. 2020

Disease Markers

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“…Recent studies have also shown that the function of p53 is closely related to ROS [58]. ROS not only regulates the activity of p53, but also participates in p53-dependent apoptosis [59]. Therefore, CCM@MSNs-ISOIM may induce the production of high levels of ROS and mediate G2/M block in NHL, which leads to apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

Zhao

Sun²,

et al. 2020

Preprint

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Background Non-Hodgkin's lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibod y targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Results Accordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, pH response, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis.Conclusions Furthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.

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“…Recent studies have also shown that the function of p53 is closely related to ROS [72]. ROS not only regulates the activity of p53, but also participates in p53-dependent apoptosis [73]. Therefore, CCM@MSNs-ISOIM may induce the production of high levels of ROS and mediate G2/M block in NHL, which leads to apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

Zhao

Sun²,

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Non-Hodgkin's lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibod y targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Therefore, we constructed a low pH value sensitivity drug delivery system based on the cancer cell membrane modified mesoporous silica nanoparticles loaded with traditional Chinese medicine, which can reduce systemic toxicity and improve the therapeutic effect for the targeted drug delivery of tumor cells. Results: Accordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis.Conclusions: Furthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.

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Proteomic Analysis Reveals that Odoroside A Triggers G2/M Arrest and Apoptosis in Colorectal Carcinoma Through ROS‐p53 Pathway

Cited by 14 publications

References 36 publications

ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis

ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis

Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

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