ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis

Zhang, Yi; Li, Qing; Song, Wei; Sun, Jing; Zhang, Xuan; He, Ling; Zhang, Lu; Xu, Zekuan; Chen, Dexuan

doi:10.1155/2020/5863178

Cited by 16 publications

(19 citation statements)

References 34 publications

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“…There are several studies investigating the apoptotic mechanism associated with the p53 gene (48)(49)(50). It is well-known that p53 plays a key role in inducing apoptosis in numerous types of cancer, such as lung, gastric and prostate cancers (51)(52)(53). In a previous study, daidzein inhibited the proliferation and NF-κB signaling pathway in lung cancer cells (54).…”

Section: Discussionmentioning

confidence: 99%

Microarray analysis of differentially expressed long non‑coding RNAs in daidzein‑treated lung cancer cells

Wang

et al. 2021

Oncol Lett

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Daidzein has been found to significantly inhibit the proliferation of lung cancer cells, while its potential molecular mechanisms remain unclear. To determine the molecular mechanism of daidzein on lung cancer cells, the Capital Bio Technology Human long non-coding (lnc) RNA Array v4, 4×180K chip was used to detect the gene expression profiles of 40,000 lncRNAs and 34,000 mRNAs in a human cancer cell line. Reverse transcription-quantitative (RT-q) PCR analysis was performed to detect the expression levels of target lncRNA and mRNAs in the H1299 cells treated with and without daidzein, using the lncRNA and mRNA gene chip. Bioinformatics analysis was performed to determine the differentially expressed genes from the results of the chip assays. There were 119 and 40 differentially expressed lncRNAs and mRNAs, respectively, that had a 2-fold change in expression level. A total of eight lncRNAs were upregulated in the H1299 lung cancer cells, while 111 lncRNAs were downregulated. Furthermore, five mRNAs were upregulated, and 35 mRNAs were downregulated. A total of six differentially expressed lncRNAs (ENST00000608897.1, ENST00000444196.1, ENST00000608741.1, XR_242163.1, ENST00000505196.1 and ENST00000498032.1) were randomly selected to validate the microarray data, which were consistent with the RT-qPCR analysis results. Differentially expressed mRNAs were enriched in important Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways. Taken together, the results of the present study demonstrated that daidzein affected the expression level of lncRNAs in lung cancer cells, suggesting that daidzein may have potential effects on lung cancer cells.

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Section: Discussionmentioning

confidence: 99%

Microarray analysis of differentially expressed long non‑coding RNAs in daidzein‑treated lung cancer cells

Wang

et al. 2021

Oncol Lett

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“…In recent years, more and more ZNFs were identified as oncogene and promoted various tumors via enhancing cell proliferation [24], promoting cell migration and invasion [25], suppressing autophagy [26], and epithelial-mesenchymal transition [27]. ZNF460 gene co-expression network analysis established that ZNF460 had a positive correlation with ZNF484, ZNF121, HMBOX1 and a negative correlation with MGAT4B, UCHL3, GTF2IRD1.…”

Section: Discussionmentioning

confidence: 99%

Overexpression of ZNF460 predicts worse survival and promotes metastasis through JAK2/STAT3 signaling pathway in patient with colon cancer

Hao

Fang

et al. 2021

J. Cancer

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Zinc finger proteins (ZNFs) are a class of protein containing zinc finger domains, and they play an important role in tumor progression. However, as a member of the ZNFs family, the effect of ZNF460 in colon cancer remains unclear. In this study, we found that the expression of ZNF460 protein were markedly increased in clinical colon cancer tissues compared with para-cancer non-cancerous tissues by tissue immunohistochemistry (IHC) and western blot (WB). We also confirmed this result at the mRNA and protein levels of ZNF460 through bioinformatics analysis. In addition, high expression of ZNF460 was correlated with increased depth of invasion (P<0.05), increased lymph node metastasis (P<0.05), distant metastasis (P<0.05) and high blood serum CA19-9 level (P<0.05). High expression of ZNF460 predicted poor overall survival (OS) and recurrence free survival (RFS) in patients with colon cancer. Moreover, multivariate analyses revealed that ZNF460 was an independent prognostic factor in both OS (hazard ratio [HR]: 1.636; 95% confidence interval [CI], 1.028-2.603; P = 0.038) and RFS (HR: 2.215; 95% CI: 1.227-3.997; P = 0.008). The knockdown of ZNF460 suppressed the invasion and metastasis of colon cancer cells in vitro. Mechanistically, we revealed that ZNF460 promotes the activation of the JAK2/STAT3 signaling pathway in colon cancer cells. Taken together, overexpression of ZNF460 predicted worse survival and promoted metastasis through JAK2/STAT3 signaling pathway in patient with colon cancer, and could be a novel therapeutic target in colon cancer.

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“…These pathways, especially the p53 pathway, are reported to contribute to cancer cell proliferation, invasion, and metastasis. [ 22 – 24 ] This implies the potential role of PYCR1 as prognostic target in AK. A recent study reported that a fraction of kindlin-2 localized to mitochondria and interacted with PYCR1.…”

Section: Discussionmentioning

confidence: 99%

Increased PYCR1 mRNA predicts poor prognosis in kidney adenocarcinoma

Zhang

Liu²,

Liu

et al. 2021

Medicine

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The pyrroline-5-carboxylate reductase 1 (PYCR1) plays important roles in cancers, but its contribution to adenocarcinoma of the kidney (AK) and the potential mechanism remain to be clarified. In this study, we aimed to demonstrate the relationship between PYCR1 mRNA and AK based on The Cancer Genome Atlas database. PYCR1 mRNA in AK and normal tissues was compared using Wilcoxon rank sum test. The relationship between PYCR1 mRNA and clinicopathological characters was evaluated using logistic regression. The association between PYCR1 mRNA and survival rate was evaluated using Kaplan-Meier test and Cox regression of univariate and multivariate analysis. Additionally, Gene Set Enrichment Analysis was conducted to annotate the biological function of PYCR1 mRNA. Increased PYCR1 mRNA was found in AK tissues. Increased PYCR1 mRNA was related to high histologic grade, clinical stage, and lymph node and distant metastasis. Kaplan-Meier survival analysis and univariate analysis showed that AK patients with increased PYCR1 mRNA had worse prognosis than those without. PYCR1 mRNA remained independently associated with overall survival (HR: 1.34; 95% CI: 1.07–1.66; P = .009) in multivariate analysis. The Gene Set Enrichment Analysis suggested that ribosome, proteasome, inhibition of p53 signaling pathway, extracellular matrix receptor interaction, and homologous recombination were differentially enriched in increased PYCR1 mRNA phenotype. Increased PYCR1 mRNA is a potential marker in patients with AK. More importantly, p53 pathway, ribosome, proteasome, extracellular matrix receptor interaction, and homologous are differentially enriched in AK patients with increased PYCR1 mRNA.

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ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis

Cited by 16 publications

References 34 publications

Microarray analysis of differentially expressed long non‑coding RNAs in daidzein‑treated lung cancer cells

Microarray analysis of differentially expressed long non‑coding RNAs in daidzein‑treated lung cancer cells

Overexpression of ZNF460 predicts worse survival and promotes metastasis through JAK2/STAT3 signaling pathway in patient with colon cancer

Increased PYCR1 mRNA predicts poor prognosis in kidney adenocarcinoma

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