Proteomic analysis of transitional cell carcinoma–like variant of tubo-ovarian high-grade serous carcinoma

Tessier‐Cloutier, Basile; Cochrane, Dawn R.; Karnezis, Anthony N.; Colborne, Shane; Magrill, Jamie; Talhouk, Aline; Zhang, Jonathan; Leung, Samuel; Hughes, Christopher S.; Piskorz, Anna; Cheng, Angela; Greening, Kendall; Bois, Andreas du; Pfisterer, Jacobus; Soslow, Robert A.; Kommoss, Stefan; Brenton, James D.; Morin, Gregg B.; Gilks, C. Blake; Huntsman, David G.; Kommoss, Friedrich

doi:10.1016/j.humpath.2020.02.006

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…A recent paper reported data obtained from proteomic analysis and found that claudin-4 (CLDN4), ubiquitin carboxyl-terminal esterase L1 (UCHL1), and minichromosome maintenance protein 7 (MCM7) were significantly higher, expressed in TCC than in HGSC of the ovary. The authors were therefore able to distinguish TCC from HGSC with those newly diagnosed proteomic markers [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Synchronous Urinary Bladder Urothelial Carcinoma and Transitional Cell Carcinoma of the Ovary: A Case Report

Rizzuto,

Slade,

Yanling

et al. 2023

Case Rep Oncol

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Transitional cell carcinoma (TCC) of the ovary is a rare subtype of epithelial ovarian tumours defined as a tumour composed of epithelial elements, histologically resembling urothelium and its neoplasms. Ovarian metastases from primary urinary tract carcinomas are rare. The differential diagnosis of primary TCC of the ovary versus metastatic bladder TCC is challenging because of histological similarity. We present the case of a 49-year-old premenopausal woman who was initially diagnosed with non-invasive papillary urothelial carcinoma of bladder (NIPUC) and after 2 years with a synchronous TCC of the ovary while being investigated for suspected relapse. She underwent a radical cystectomy, total hysterectomy, bilateral salpingo-oopharectomy, and pelvic lymph node dissection. The final diagnosis of synchronous NIPUC of the bladder and TCC of the ovary was made by histopathology and immunohistochemical studies.

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Section: Discussionmentioning

confidence: 99%

Synchronous Urinary Bladder Urothelial Carcinoma and Transitional Cell Carcinoma of the Ovary: A Case Report

Rizzuto,

Slade,

Yanling

et al. 2023

Case Rep Oncol

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“…CLDN3 staining was scored by the pathologist in all cases. An IHC score was assigned to each score, as per the reports in a previous study 38…”

Section: Elisamentioning

confidence: 99%

Utility of Claudin-3 in extracellular vesicles from human bile as biomarkers of cholangiocarcinoma

Ikeda

Haga

Makino

et al. 2021

Sci Rep

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Extracellular vesicles (EVs) are released from all cells. Bile directly contacts bile duct tumor; bile-derived EVs may contain high concentrations of cancer biomarkers. We performed a proteomic analysis of human bile-derived EVs and identified a novel biomarker of cholangiocarcinoma (CCA). EVs were isolated using ultracentrifugation, and chelating agents, ethylenediaminetetraacetic acid and ethylene glycol tetraacetic acid (EDEG) and phosphate buffered saline (PBS) were used as dissolution solutions. Bile was collected from 10 CCA and 10 choledocholithiasis (stones) cases. Proteomic analysis was performed; subsequently, ELISA was performed using the candidate biomarkers in a verification cohort. The vesicles isolated from bile had a typical size and morphology. The expression of exosome markers was observed. RNA was more abundant in the EDEG group. The proportion of microRNA was higher in the EDEG group. EDEG use resulted in the removal of more contaminants. Proteomic analysis identified 166 proteins as CCA-specific. ELISA for Claudin-3 revealed statistically significant difference. The diagnostic accuracy was AUC 0.945 and sensitivity and specificity were 87.5%. We report the first use of EDEG in the isolation of EVs from human bile and the proteomic analysis of human bile-derived EV-proteins in CCA. Claudin-3 in bile-derived EVs is a useful biomarker for CCA.

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Overview of Ovarian Tumours: Pathogenesis and General Considerations

Vroobel

2023

Essentials of Diagnostic Gynecological Pathology

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Proteomic analysis of transitional cell carcinoma–like variant of tubo-ovarian high-grade serous carcinoma

Cited by 5 publications

References 53 publications

Synchronous Urinary Bladder Urothelial Carcinoma and Transitional Cell Carcinoma of the Ovary: A Case Report

Synchronous Urinary Bladder Urothelial Carcinoma and Transitional Cell Carcinoma of the Ovary: A Case Report

Utility of Claudin-3 in extracellular vesicles from human bile as biomarkers of cholangiocarcinoma

Overview of Ovarian Tumours: Pathogenesis and General Considerations

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