Proteome Changes of Human Bone Marrow Mesenchymal Stem Cells Induced by 1,4-Benzoquinone

Wu, Wei; Zhang, Ling; Zhang, Min; Zhu, Lijin; Xia, Hailing; Lou, Jianlin; Liu, Jia-Ren; Xiao, Yun

doi:10.1155/2016/2789245

Cited by 27 publications

(14 citation statements)

References 41 publications

(47 reference statements)

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“…These findings were consistent with previous studies 16 , 22 . Wu et al 23 found that the deformation amplitude (DA) exhibited excellent repeatability with a S w of 0.098, which was similar to our result, albeit slightly higher. Nemeth et al 17 showed good repeatability for IOP and pachymetric values, whereas other measurements.…”

Section: Discussionsupporting

confidence: 91%

Assessment of corneal biomechanics, tonometry and pachymetry with the Corvis ST in myopia

Wang

McAlinden

Zhang

et al. 2021

Sci Rep

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To evaluate the repeatability of Corvis ST corneal biomechanical, tonometry and pachymetry measurements, and agreement of pachymetry measures with the Pentacam HR and RTVue OCT. Three consecutive measurements of the right eye of 238 myopic subjects were acquired with the Corvis ST, Pentacam HR, and RTVue OCT. Repeatability of Corvis ST was evaluated by within-subject standard deviation [Sw] and repeatability limit [r]. The agreement of central corneal thickness (CCT) measurements were compared among the three instruments using the Bland–Altman limits of agreement. Comparisons were further stratified by CCT (Corneathin ≤ 500 µm; Corneanormal = 500–550 µm; Corneathick > 550 µm). Sw was below 1 mmHg in Corneathin, Corneanormal, and Corneathick groups for IOP and bIOP. Sw for SP-A1 were 4.880, 6.128, 7.719 mmHg/mm respectively. Sw for CBI were 0.228, 0.157, 0.076, and correspondingly Sw for TBI and SSI were 0.094 and 0.056, 0.079 and 0.053, 0.070 and 0.053. The Bland–Altman plots for CCT implied poor agreement with mean differences of 29.49 µm between Corvis and OCT, 9.33 µm between Pentacam and OCT, and 20.16 µm between Corvis and Pentacam. The Corvis ST showed good repeatability with the exception of CBI in the various CCT groups. The CCT measured by Corvis ST was not interchangeable with Pentacam HR and RTVue OCT.

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Section: Discussionsupporting

confidence: 91%

Assessment of corneal biomechanics, tonometry and pachymetry with the Corvis ST in myopia

Wang

McAlinden

Zhang

et al. 2021

Sci Rep

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“…All studies originated in Europe with the exception of Yu 2015, Dai 2014, and Zhang 2016 [ 19 , 21 , 22 ]. Nine studies were prospective in design [ 17 , 19 , 20 , 22 , 24 , 25 , 28 – 30 ], and seven were carried out at multiple institutions [ 17 , 18 , 20 , 21 , 24 , 25 , 31 ]. No phase IV trials were identified for inclusion.…”

Section: Resultsmentioning

confidence: 99%

“…All included studies received between five or six points on the NOS, suggesting that they carried an intermediate risk of bias. Two studies, De Vos 2013 and Zhang 2016, included patients already in clinical remission, additional sensitivity analyses were run with these studies excluded (Additional file 3 : Figure S1) [ 17 , 22 ].…”

Section: Resultsmentioning

confidence: 99%

Systematic review and meta-analysis: real-world data rates of deep remission with anti-TNFα in inflammatory bowel disease

et al. 2021

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Background Deep remission (DR) is a treatment target in IBD associated with reduced hospitalization and improved outcome. Randomized control trial (RCT) data demonstrates efficacy of anti-TNFα agents in achieving DR; however, real-world data (RWD) can provide information complementary to RCTs, specifically regarding treatment duration. In this systematic review with meta-analysis, we use real-world data (RWD) to determine rates of DR in IBD treated with anti-TNFα. Methods We completed a systematic search of MEDLINE and EMBASE on July 8, 2019 with review of major gastrointestinal conference abstracts from 2012 to 2019. Studies utilizing RWD (data not from phase I-III RCTs) of adult IBD patients treated with anti-TNFα agents were included. DR was defined by clinical and endoscopic remission at minimum. DR was assessed at 8 weeks, 6 months, 1 year, and 2 years. Risk of bias was assessed with the Newcastle Ottawa Scale. Results 29,033 publications were identified. Fifteen publications, nine manuscripts and six conference abstracts, were included encompassing 1212 patients (769 Crohn’s disease-CD, 443 ulcerative colitis-UC), and analyzed using Comprehensive Meta-Analysis. Rate of DR was 36.4% (95% CI 12.6–69.4%) at 8 weeks, 39.1% (95% CI 10.4–78%) at 6 months, 44.4% (95% CI 34.6–54.6%) at 1 year, and 36% (95% CI 18.7–58%) at 2 years. DR in CD at 1 year was 48.6% (95% CI 32.8–64.7%) and in UC was 43.6% (95% CI 32.8–55.1%). Conclusions The rate of DR was highest after 1 year of therapy, in nearly 45% of IBD patients treated with anti-TNFα. Similar rates were achieved between patients with UC and CD. The findings highlight the efficacy of anti-TNFα in real-world setting. Future studies using RWD can determine efficacy of newer IBD therapeutics in routine clinical practice.

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“…Multiple studies have linked benzene exposure to reduced leukocytes, erythrocytes, neutrophil, and lymphocytes counts. 163 , 164 Benzene metabolites significantly impair survival of cultured human BM MSCs 165 and alter the function of human BM endothelial cells. 166 , 167 Furthermore, benzene increases the risk of a broad range of hematological malignancies and disorders.…”

Section: Lifestyle Factors and Their Influence On Hsc Nichesmentioning

confidence: 99%

The Impact of Sedentary Lifestyle, High-fat Diet, Tobacco Smoke, and Alcohol Intake on the Hematopoietic Stem Cell Niches

Kaastrup

Grønbæk

2021

HemaSphere

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Hematopoietic stem and progenitor cells maintain hematopoiesis throughout life by generating all major blood cell lineages through the process of self-renewal and differentiation. In adult mammals, hematopoietic stem cells (HSCs) primarily reside in the bone marrow (BM) at special microenvironments called “niches.” Niches are thought to extrinsically orchestrate the HSC fate including their quiescence and proliferation. Insight into the HSC niches mainly comes from studies in mice using surface marker identification and imaging to visualize HSC localization and association with niche cells. The advantage of mouse models is the possibility to study the 3-dimensional BM architecture and cell interactions in an intact traceable system. However, this may not be directly translational to human BM. Sedentary lifestyle, unhealthy diet, excessive alcohol intake, and smoking are all known risk factors for various diseases including hematological disorders and cancer, but how do lifestyle factors impact hematopoiesis and the associated niches? Here, we review current knowledge about the HSC niches and how unhealthy lifestyle may affect it. In addition, we summarize epidemiological data concerning the influence of lifestyle factors on hematological disorders and malignancies.

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Proteome Changes of Human Bone Marrow Mesenchymal Stem Cells Induced by 1,4-Benzoquinone

Cited by 27 publications

References 41 publications

Assessment of corneal biomechanics, tonometry and pachymetry with the Corvis ST in myopia

Assessment of corneal biomechanics, tonometry and pachymetry with the Corvis ST in myopia

Systematic review and meta-analysis: real-world data rates of deep remission with anti-TNFα in inflammatory bowel disease

The Impact of Sedentary Lifestyle, High-fat Diet, Tobacco Smoke, and Alcohol Intake on the Hematopoietic Stem Cell Niches

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