Proteolytic Activity in Human Thyroid Extracts. I. Purification and Properties of Some Proteinases.

Lundblad, Gunnar; Bernbäck, Marie-Louise; Widemann, C.; Kulonen, E.; Brunvoll, J.; Bunnenberg, E.; Djerassi, Carl; Records, Ruth

doi:10.3891/acta.chem.scand.20-0675

Acta Chem. Scand.

1966

DOI: 10.3891/acta.chem.scand.20-0675

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Proteolytic Activity in Human Thyroid Extracts. I. Purification and Properties of Some Proteinases.

Gunnar Lundblad¹,

Marie-Louise Bernbäck²,

C. Widemann³

et al.

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Cited by 10 publications

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“…The time course of the caseinolytic reaction by this catheptic activity and the relationships between the catheptic activity and amounts of protein contained in the ovarian extract were investigated. 3. It was suggested that the catheptic activity in the corpus luteum was higher than that in the ovarian follicle.…”

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A Catheptic Activity in the Ovarian Extract of the Rat Treated with PMS and HCG

Yoshida¹,

Higuchi²

1975

Nihon Chikusan Gakkaiho

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In recent years the cathepsin type proteases (intracellular acid proteases present in the animal tissues**) have been reported to exist in a variety of animal tissues, and some of these proteases have been highly purified1-3). Moreover, some reports on their distribution in the cell4,5) or on their enzymological properties1-3.6) have been accumulated. The presence of an acid protease activity (i.e., catheptic activity) has also been reported in the ovaries of human7,8), sows7,8), dairy cows9), and rats10,11), and the relationship between the activities of both the cathepsin type and the alkaline proteases and the ovarian function or the response to the gonadotropin treatment has been discussed. The properties of these enzymes in the ovary, however, have been little known yet, and the physiological significances of these enzymes are still a matter of speculation.From these points of view, we paid attention to the physiological relations between the ovarian function and the proteolytic enzymes of the ovary, and conducted the investigations on the proteolytic activities present in the ovary of the immature rats pretreated with gonadotropins by using the more sensitive assay method than the measurement of light absorption at 280nm and by using the assay medium without urea. During the course of these experiments, a catheptic activity was found in the supernatant fluid of the rat ovarian homogenate used in the experiment, but the alkaline protease activity was little detected in the fluid. The present report describes the level and some properties of the catheptic activity of the ovary.

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A Catheptic Activity in the Ovarian Extract of the Rat Treated with PMS and HCG

Yoshida¹,

Higuchi²

1975

Nihon Chikusan Gakkaiho

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Nachweis und Verteilungsmuster der sauren Carboxypeptidase in menschlichen Geweben und ihre Beziehung zur Kathepsin-Aktivität

Stein

Platt

1968

Klin Wochenschr

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Iodide goiter and the pharmacologic effects of excess iodide

Wolff¹

1969

The American Journal of Medicine

316

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Proteolytic Activity in Human Thyroid Extracts. I. Purification and Properties of Some Proteinases.

Cited by 10 publications

References 0 publications

A Catheptic Activity in the Ovarian Extract of the Rat Treated with PMS and HCG

A Catheptic Activity in the Ovarian Extract of the Rat Treated with PMS and HCG

Nachweis und Verteilungsmuster der sauren Carboxypeptidase in menschlichen Geweben und ihre Beziehung zur Kathepsin-Aktivität

Iodide goiter and the pharmacologic effects of excess iodide

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