1971
DOI: 10.1016/0005-2795(71)90216-9
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Proteoglycans of cartilage: An assessment of their structure

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Cited by 68 publications
(32 citation statements)
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“…Some of the proteoglycans in cartilage exist as aggregates ; these would be Vol. 130 present amongst the proteoglycans prepared by the procedure used here and would be excluded from Sepharose 4B since they are excluded from Sepharose 2B (Tsiganos et al, 1971). The diminished proportions of proteoglycans excluded from Sepharose 4B in the cartilages of the lame groups (Table 4), particularly at 10 weeks of age, suggest that fewer aggregates were present, either because there was less of the aggregating component or because there was a greater proportion of smaller proteoglycans, which appear to be unable to form aggregates (Hardingham & Muir, 1972).…”
Section: Discussionmentioning
confidence: 99%
“…Some of the proteoglycans in cartilage exist as aggregates ; these would be Vol. 130 present amongst the proteoglycans prepared by the procedure used here and would be excluded from Sepharose 4B since they are excluded from Sepharose 2B (Tsiganos et al, 1971). The diminished proportions of proteoglycans excluded from Sepharose 4B in the cartilages of the lame groups (Table 4), particularly at 10 weeks of age, suggest that fewer aggregates were present, either because there was less of the aggregating component or because there was a greater proportion of smaller proteoglycans, which appear to be unable to form aggregates (Hardingham & Muir, 1972).…”
Section: Discussionmentioning
confidence: 99%
“…The range of densities obtained in several representative experiments is shown in the last column of the table. The relative concentrations of protein and uronate in BCC-SPG in both associative and dissociative gradients follow the general pattern established in severn other studies for cartilage [17,[21][22][23]; the concentration of uronate is greatest in the higher density fractions, and the ratio of uronate to protein decreases with decreasing buoyant densities. This pattern is found for SPG and for the RPG derived from the residue.…”
Section: Resultsmentioning
confidence: 50%
“…However, this sort of argument is almost certainly too simple. Tsiganos et al (1970) report that there is not only an increase of protein, but also of keratan sulphate, towards the top of a caesium chloride gradient of starting density 1.5g/ml. In our case, the small content of hexuronic acid in the glycoproteins may be due to some chondroitin sulphate associated with keratan sulphate.…”
Section: Discussionmentioning
confidence: 96%