Proteoglycan Synthesis is Not Influenced by Zinc in Proliferating Bovine Aortic Endothelial Cells in Culture

Abstract

Zinc promotes the proliferation of bovine aortic endothelial cells depending on endogenous fibroblast growth factor-2 whose activity is modulated by proteoglycans. In this study, we investigated the effects of zinc on the synthesis of proteoglycans in proliferating cells. It was demonstrated that zinc neither influenced the core protein synthesis nor the glycosaminoglycan chain formation during the synthesis of proteoglycan molecules, suggesting that zinc stimulation of endothelial cell proliferation is independent of proteoglycan synthesis.

Zn(ii)2,9-dimethyl-1,10-phenanthroline stimulates cultured bovine aortic endothelial cell proliferation

“…10,11 This stimulation depends on endogenous FGF-2; however, zinc does not affect the expression of perlecan and the structure of heparan sulfate chains as well as the expression of FGF-2 and FGFR. 28 It appears challenging to analyze the mechanisms underlying vascular endothelial cell proliferation using inorganic zinc as a molecular probe. Recently, from the viewpoint of toxicology, we have proposed bio-organometallics to analyze biological systems with organic-inorganic hybrid molecules as molecular probes.…”