Proteinuria and glomerular hypertrophy in extremely low‐birthweight children

Hayashi, Asako; Santo, Yoko; Satomura, Kenichi

doi:10.1111/ped.12466

Cited by 16 publications

(10 citation statements)

References 8 publications

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“…There is increasing evidence that some children with LBW already have decreased renal function. We reported some LBW infants who showed proteinuria and glomerular hypertrophy from childhood . Frankfurt et al .…”

mentioning

confidence: 73%

“…We reported some LBW infants who showed proteinuria and glomerular hypertrophy from childhood. 8 Frankfurt et al showed that infants with lower birthweight and gestational age had a reduced estimated GFR (eGFR) based on cystatin C (CysC) levels (CysC-eGFR) at 3 years of age. 9 Furthermore, not all LBW infants develop CKD, and certain prognostic factors are likely to affect the onset of CKD.…”

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confidence: 99%

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Risk factors associated with a decreased estimated glomerular filtration rate based on cystatin C levels in school‐age children with extremely low birthweight

et al. 2017

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confidence: 73%

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confidence: 99%

Risk factors associated with a decreased estimated glomerular filtration rate based on cystatin C levels in school‐age children with extremely low birthweight

et al. 2017

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“…Renal biopsy showed a diffuse increase in glomerular size, consistent with glomerular hypertrophy. The authors speculated that there was compensatory glomerular hyperfiltration, hypertrophy and hypertension in children born with extremely low birthweight when they developed proteinuria . Observational studies have also revealed high rates of CKD in survivors of neonatal acute kidney injury.…”

Section: Discussionmentioning

confidence: 99%

Renal hyperfiltration defined by high estimated glomerular filtration rate: A risk factor for cardiovascular disease and mortality

Kanbay

Ertuğlu

Afsar

et al. 2019

Diabetes Obesity Metabolism

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Renal hyperfiltration, defined as an increased glomerular filtration rate above normal values, is associated with early phases of kidney disease in the setting of various conditions such as obesity and diabetes. Although it is recognized that glomerular hyperfiltration, that is, increased filtration per nephron unit (usually studied at low glomerular filtration levels and often referred to as single nephron hyperfiltration), is a risk factor for the progression of chronic kidney disease, the implications of having renal hyperfiltration for cardiovascular disease and mortality risk are incompletely understood. Recent evidence from diverse populations, including healthy individuals and patients with diabetes or established cardiovascular disease, suggests that renal hyperfiltration is associated with a higher risk of cardiovascular disease and all‐cause mortality. In this review, we critically summarize the existing studies, discuss possible mechanisms, and describe the remaining gaps in our knowledge regarding the association of renal hyperfiltration with cardiovascular disease and mortality risk.

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“…This form of hypertrophy could have arisen from considerable changes in efferent and afferent flows/pressures exerted on acellular glomeruli 43 . Excessive filtration and proteinuria could have also contributed to the condition 44 . Cellular debris and vascular cast formation in the Bowman's space that could have arisen from ischemia-derived blood cell apoptosis or necrosis observed in chronic diseases are also likely contributing factors 45 .…”

Section: Severe Dextran Extravasation and Alterations To Capillary Blood Flow Observed Across One Week Of Transplantationmentioning

confidence: 99%

Assessing the Live Decellularized Renal Microvasculature Post-Transplantation Using Intravital Microscopy

Corridon

Khan

2021

Preprint

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Transplantation is the ideal solution for end-stage renal failure, but the growing mismatch between organ supply and demand accentuates the need for alternative solutions like the bioartificial kidney. Several approaches to developing this technology have been demonstrated, and whole organ decellularization appears to be a promising methodology. One major challenge to this strategy is maintaining vascular integrity and functionality post-transplantation. Most models to examine the microvasculature have primarily utilized in vitro or in vivo techniques that are incapable of providing adequate spatial and temporal resolution. Here, we show that decellularized scaffolds orthotopically transplanted into rats initially retain microvascular structure in vivo using intravital two-photon microscopy, as previously identified in vitro. Large molecular weight dextran molecules also provide real-time evidence of the onset of ischemia and increases in microvascular permeability, support substantial translocation of dextran macromolecules from glomerular and peritubular capillary tracks as early as 12 hours after transplantation. Macromolecular extravasation continued across a week, at which time the decellularized microarchitecture was significantly compromised. These results indicate that a in vivo method capable of tracking microvascular integrity represents a powerful interdisciplinary approach for studying scaffold viability and identifying ways to promote scaffold longevity and angiogenesis in bioartificial organs.

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Proteinuria and glomerular hypertrophy in extremely low‐birthweight children

Cited by 16 publications

References 8 publications

Risk factors associated with a decreased estimated glomerular filtration rate based on cystatin C levels in school‐age children with extremely low birthweight

Risk factors associated with a decreased estimated glomerular filtration rate based on cystatin C levels in school‐age children with extremely low birthweight

Renal hyperfiltration defined by high estimated glomerular filtration rate: A risk factor for cardiovascular disease and mortality

Assessing the Live Decellularized Renal Microvasculature Post-Transplantation Using Intravital Microscopy

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