Risk factors associated with a decreased estimated glomerular filtration rate based on cystatin C levels in school‐age children with extremely low birthweight

Yamamura-Miyazaki, Natsumi; Yamamoto, Katsusuke; Fujiwara, Kaori; Santo, Yoko; Michigami, Toshimi; Kohno, Hiroyuki; Satomura, Kenichi

doi:10.1111/nep.12807

Cited by 4 publications

(14 citation statements)

References 27 publications

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“…In a sample of 422 young adults born before 32 weeks of gestation, 10% had elevated blood pressure and 2.7% had microalbuminuria, as compared to 33.3% with elevated blood pressures and 11.9% with microalbuminuria in the sample described here (38,39). Likely explanations are that the mean gestational age and birth weight were lower in our sample as compared to those studied previously, and the relatively high frequency of African-American (42.9%) and overweight (53.8%) children in our cohort (34,(40)(41)(42)(43)(44)(45)(46). Both overweight status and African-American race are independent risk factors for CKD related to hyperfiltration, obesity related focal segmental glomerulosclerosis, and the genetic predisposition to develop CKD (6,44,47).…”

Section: Discussioncontrasting

confidence: 46%

“…We found that none of the hypothesized neonatal risk factors were associated with the presence of one or more abnormal kidney outcome (microalbuminuria, elevated blood pressures, and/or reduced kidney volume) during adolescence. Yamamura-Miyazaki et al found that a lower 5-min Apgar was associated with decreased cystatin C-estimated glomerular filtration rate in school aged children after preterm birth (46). This could not be assessed here as glomerular filtration rate was not assessed in the ELGAN sample.…”

Section: Discussionmentioning

confidence: 89%

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Albuminuria, Hypertension, and Reduced Kidney Volumes in Adolescents Born Extremely Premature

et al. 2020

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Background: Premature birth is associated with decreased nephron number and an increased risk for chronic kidney disease (CKD). To inform the development of guidelines for kidney follow up of children born prematurely, we undertook a study of individuals born extremely preterm, with the aim of characterizing the prevalence and predictors of microalbuminuria, elevated blood pressure, and/or abnormal kidney volume in adolescence. Methods: Study participants (n = 42) were born before 28 weeks of gestation and were enrolled at birth in the Extremely Low Gestational Age Newborns (ELGAN) study. When participants were 15 years old, we obtained 2 manual blood pressures, a spot urine microalbumin measurement, and sonographic measurements of kidney length and volume. Results: Of the 42 participants, 60% were male, 52% were Caucasian (18% Hispanic), and 43% were African-American. Their median age was 15 (IQR 15, 15.3) years. In 33.3% of the cohort, blood pressure was elevated (>120/80 mmHg). Microalbuminuria (>30 mg/g) was present in 11.9% of the cohort, and kidney volume below the 10th percentile of normative data was present in 14%. Twenty-one (50%) of the sample had at least one kidney abnormality (microalbuminuria, elevated blood pressures, and/or kidney hypoplasia); these individuals were more likely to have experienced neonatal hypotension [55% vs. 17% among those with no kidney abnormality, p = 0.02]. Conclusions: Half of adolescents in this subset of ELGAN cohort have at least one risk factor of kidney disease (reduced kidney volume, microalbuminuria, and/or elevated blood pressures) at 15 years of age. This study suggests the importance of monitoring kidney outcomes in children after extremely preterm birth, especially those with a history of neonatal hypotension.

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Section: Discussioncontrasting

confidence: 46%

Section: Discussionmentioning

confidence: 89%

Albuminuria, Hypertension, and Reduced Kidney Volumes in Adolescents Born Extremely Premature

et al. 2020

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“…Following the search strategy described, 248 (232 + 16) hits were analyzed to result in 6 case-control and 3 ELBW cohort studies for the analysis (Figure 1). The key characteristics of the individual case-control studies are provided in Table 1 [12][13][14][15][16][17][18], cohort studies in Table 2 [19][20][21].…”

Section: Resultsmentioning

confidence: 99%

Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis

Goetschalckx

Mekahli

Levtchenko

et al. 2020

IJERPH

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Various cohort studies document a lower glomerular filtration rate (GFR) in former extremely low birth weight (ELBW, <1000 g) neonates throughout childhood when compared to term controls. The current aim is to pool these studies to describe the GFR pattern over the pediatric age range. To do so, we conducted a systematic review on studies reporting on GFR measurements in former ELBW cases while GFR data of healthy age-matched controls included in these studies were co-collected. Based on 248 hits, 6 case-control and 3 cohort studies were identified, with 444 GFR measurements in 380 former ELBW cases (median age 5.3–20.7 years). The majority were small (17–78 cases) single center studies, with heterogeneity in GFR measurement (inulin, cystatin C or creatinine estimated GFR formulae) tools. Despite this, the median GFR (mL/min/1.73 m2) within case-control studies was consistently lower (−13%, range −8% to −25%) in cases, so that a relevant minority (15–30%) has a eGFR<90 mL/min/1.73 m2). Consequently, this pooled analysis describes a consistent pattern of reduced eGFR in former ELBW cases throughout childhood. Research should focus on perinatal risk factors for impaired GFR and long-term outcome, but is hampered by single center cohorts, study size and heterogeneity of GFR assessment tools.

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“…Following the search strategy described, 248 (232 + 16) hits were analyzed to result in 6 casecontrol and 3 ELBW cohort studies for the analysis [Figure 1]. The key characteristics of the individual case-control studies are provided in Table 1 [12][13][14][15][16][17][18], cohort studies in Table 2 [19][20][21]. Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 19 January 2020 doi:10.20944/preprints202001.0213.v1…”

Section: Resultsmentioning

confidence: 99%

“…Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 19 January 2020 doi:10.20944/preprints202001.0213.v1 Figure 2. Mean or median (estimated) glomerular filtration rate (eGFR) in the 6 case-control studies over age (years) [12][13][14][15][16][17]. The arrows connect the same cohort assessed at the age of 7 and 11 years respectively [17,18] (ELBW: extreme low birth weight).…”

Section: Discussionmentioning

confidence: 99%

Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis

Goetschalkx¹,

Mekahli²,

Levtchenko³

et al. 2020

Preprint

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Different cohort studies documented a lower glomerular filtration rate (GFR) in former extremely low birth weight (ELBW, <1000 g) neonates throughout childhood when compared to term controls. The current aim is to pool these studies to describe the GFR pattern over the pediatric age range. To do so, we conducted a systematic review on studies reporting on GFR measurements in former ELBW cases while GFR data of healthy age-matched controls included in these studies were co-collected. Based on 248 hits, 6 case-control and 3 cohort studies were identified, with 444 GFR measurements in 380 former ELBW cases (median age 5.3-20.7 years). The majority were small (17-78 cases) single center studies, with heterogeneity in GFR measurement (inulin, Cystatin C or creatinine estimated GFR formulae) tools. Despite this, the median GFR (ml/kg/1.73m2) within case-control studies was consistently lower (-13, range -8 to -25%) in cases, so that a relevant minority (15-30%) has a eGFR<90 mgl/kg/1.73m2). Consequently, this pooled analysis describes a consistent pattern of reduced eGFR in former ELBW cases throughout childhood. Research should focus on perinatal risk factors for impaired GFR and long-term outcome, but is hampered by single center cohorts, study size, and heterogeneity of GFR assessment tools.

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Risk factors associated with a decreased estimated glomerular filtration rate based on cystatin C levels in school‐age children with extremely low birthweight

Abstract: CysC-eGFR might already be decreased at school age in children born with ELBW. Renal assessment in regular follow-up examinations is recommended.

Cited by 4 publications

References 27 publications

Albuminuria, Hypertension, and Reduced Kidney Volumes in Adolescents Born Extremely Premature

Albuminuria, Hypertension, and Reduced Kidney Volumes in Adolescents Born Extremely Premature

Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis

Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis

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