Proteins Derived from Cnidium officinale Makino React with Serum IgE of Allergic Patients and Stimulate ERK/NF-kB Activation in Human Mast Cell Line HMC-1 Cells

Park, Jiyoung; Lee, In Seung; Kim, Yumi; An, Eun Jin; Jung, Woo Sang; Jang, Hyeung-Jin

doi:10.1007/s13206-021-00008-1

Cited by 4 publications

(3 citation statements)

References 37 publications

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“… 38 IgE‐mediated drug hypersensitivity is contributed to drug‐sIgE through covalently binding to mast cells or basophils with FcεRI based on the “hapten” theory. 39 Jang et al 40 show that crosslinking Cnidium officinale Makino‐sIgE stimulated mast cell activation through extracellular singal‐regulated Kinases (ERK)/nuclear factor kappa‐light‐chain‐enhancer of Activated B Cells (NF‐kB) pathway. However, some new mechanisms of IgE‐mediated drug hypersensitivity emerge when considering the different dynamics of forming noncovalent drug–protein complexes or covalent hapten–protein adducts 41 : (i) reduced mast cell reactivity; (ii) noncovalent drug–protein complexes called “fake antigens” with cross‐link preformed drug‐sIgE; (iii) a metabolic step for forming a reactive metabolite.…”

Section: Discussionmentioning

confidence: 99%

Knowledge mapping and global trends of drug hypersensitivity from 2013 to 2023: A bibliometric analysis

Luo,

Chen,

et al. 2024

Immunity Inflam & Disease

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BackgroundDrug hypersensitivity is a major global public health issue with a significant increase in prevalence in populations. Here, we provide a deep insight into the frontier hotspot and future direction in the field of drug hypersensitivity.MethodsA knowledge map is portrayed based on publications related to drug hypersensitivity from Web of Science Core Collection using CiteSpace. Co‐occurrence relationships of countries, institutes, authors, journals, references, and keywords are constructed. According to the co‐occurrence relationships, hotspots and future trends are overviewed.ResultsThe United States ranked first in the world and China with the second highest publications was the only developing country. Torres, Mayorga, and Blanca were highly productive authors. Harvard University was the institution with the most research publications. Keywords co‐occurrence analysis suggested applications in emerging causes, potential mechanisms, and clinical diagnosis as the research hotspots and development frontiers.ConclusionResearch on drug hypersensitivity is in a rapid development stage and an emerging trend in reports of anaphylaxis to polyethylene glycols is identified. Developing algorithms for understanding the standardization process of culprit drugs, clinical manifestations, and diagnostic methods will be the focus of future direction. In addition, a better understanding of the mechanisms to culprit drugs with immunological precise phenotypic definitions and high‐throughput platforms is needed.

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Section: Discussionmentioning

confidence: 99%

Knowledge mapping and global trends of drug hypersensitivity from 2013 to 2023: A bibliometric analysis

Luo,

Chen,

et al. 2024

Immunity Inflam & Disease

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“…DC-spiked serum samples were prepared by spiking the human serum product with a known concentration of DC. DC-spiked serum samples were treated using the acetonitrile–formic acid extraction method. − In this method, serum samples (100 μL) were diluted to acetonitrile/formic acid (99:1, v/v, 400 μL) and incubated in an ice bath for 30 min. The mixtures were centrifuged at 14 000 rpm and 4 °C for 10 min, and the supernatant (300 μL) was transferred to a fresh EP tube for further analysis.…”

Section: Methodsmentioning

confidence: 99%

Laser-Assisted Desorption/Ionization Mass Spectrometry Using Nanoporous SiO₂ Aerogels for the Diagnosis of Colon Cancer

Yun

Kim

Noh

et al. 2022

ACS Appl. Nano Mater.

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The SiO2 aerogel has a porous network of spherical silica particles with an average size of 3–5 nm, which provides an extremely high surface area. Herein, SiO2 aerogel was synthesized using the sol–gel method with sodium silicate as a precursor, and the SiO2 aerogel was applied to matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) as an inorganic matrix for quantitative analysis. In this work, a combi-matrix was prepared by mixing the SiO2 aerogel and a conventional organic matrix (CHCA) for quantitative analysis of analytes at an m/z ratio of less than 500. Using the combi-matrix based on the SiO2 aerogel with an extremely high porosity, analyte ionization was performed without the mass peaks of the organic matrix (CHCA) for MALDI-MS. The optimal ratio between the SiO2 aerogel and the organic matrix was determined to eliminate the mass peaks from the organic matrix and maximize the signal-to-noise ratio (S/N ratio) of the analytes. Quantitative analysis was performed using the optimal combi-matrix system (a mixture of SiO2 aerogel and organic matrix (CHCA)). The homogeneous and dense distribution of analytes was demonstrated using fluorescence imaging, and the spot-to-spot and shot-to-shot reproducibility was estimated using the SiO2 aerogel. Finally, LDI-MS based on the combi-matrix was applied for the quantitative analysis of a biomarker for colon cancer, dodecanoyl-l-carnitine (DC). Using real samples from healthy volunteers and patients, a medical diagnosis of colon cancer was demonstrated using a combi-matrix.

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“…In HMC-1 cells, the combination of positive serum containing COM specific IgE with COM extract induced ERK/NF-kB synergistic effect of activation, but negative serum did not show significant changes. [57] In addition, the antiallergic activities of COM 95 % ethanol extract is between 40 %-50 %. In mast cells, COM root extract has antiallergic activity at low, medium and high concentrations.…”

Section: Antiallergic Activitiesmentioning

confidence: 99%

Cnidium officinale Makino: Phytology, Phytochemistry, Toxicology, Pharmacology and Prescriptions (1967–2023)

Ma,

Liu,

Wang

et al. 2023

Chemistry & Biodiversity

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Cnidium officinale Makino (COM), a perennial herbaceous plant in the Apiaceous family, widely distribute in Eastern Asia and Asia‐Temperate. It has a long history application as a traditional medicine for invigorating the blood and removing blood stasis, and also has been employed to diet, pesticide, herbal bathing materials, the cosmetic and skin care industry. However, there has been no associated review of literature in the past half a century (1967–2023). By searching the international authoritative databases and collecting 229 literatures closely related to COM, herewith a comprehensive and systematic review was conducted. The phytology includes plant distribution and botanical characteristics. The phytochemistry covers 8 major categories, 208 compounds in total, and the quantitative determination of 14 monomer compounds, total polyphenols and total flavonoids. The clinical trial in pregnant women and toxic experiments in mice, the pharmacology of 7 aspects and 82 frequently used prescriptions are summarized. It is expected that this paper will provide forward‐looking scientific thinking and literature support for the further modern research, development and utilization of COM.

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Proteins Derived from Cnidium officinale Makino React with Serum IgE of Allergic Patients and Stimulate ERK/NF-kB Activation in Human Mast Cell Line HMC-1 Cells

Cited by 4 publications

References 37 publications

Knowledge mapping and global trends of drug hypersensitivity from 2013 to 2023: A bibliometric analysis

Knowledge mapping and global trends of drug hypersensitivity from 2013 to 2023: A bibliometric analysis

Laser-Assisted Desorption/Ionization Mass Spectrometry Using Nanoporous SiO₂ Aerogels for the Diagnosis of Colon Cancer

Cnidium officinale Makino: Phytology, Phytochemistry, Toxicology, Pharmacology and Prescriptions (1967–2023)

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Proteins Derived from Cnidium officinale Makino React with Serum IgE of Allergic Patients and Stimulate ERK/NF-kB Activation in Human Mast Cell Line HMC-1 Cells

Cited by 4 publications

References 37 publications

Knowledge mapping and global trends of drug hypersensitivity from 2013 to 2023: A bibliometric analysis

Knowledge mapping and global trends of drug hypersensitivity from 2013 to 2023: A bibliometric analysis

Laser-Assisted Desorption/Ionization Mass Spectrometry Using Nanoporous SiO2 Aerogels for the Diagnosis of Colon Cancer

Cnidium officinale Makino: Phytology, Phytochemistry, Toxicology, Pharmacology and Prescriptions (1967–2023)

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Laser-Assisted Desorption/Ionization Mass Spectrometry Using Nanoporous SiO₂ Aerogels for the Diagnosis of Colon Cancer