Cnidium officinale Makino: Phytology, Phytochemistry, Toxicology, Pharmacology and Prescriptions (1967–2023)

Abstract

Cnidium officinale Makino (COM), a perennial herbaceous plant in the Apiaceous family, widely distribute in Eastern Asia and Asia‐Temperate. It has a long history application as a traditional medicine for invigorating the blood and removing blood stasis, and also has been employed to diet, pesticide, herbal bathing materials, the cosmetic and skin care industry. However, there has been no associated review of literature in the past half a century (1967–2023). By searching the international authoritative databases and collecting 229 literatures closely related to COM, herewith a comprehensive and systematic review was conducted. The phytology includes plant distribution and botanical characteristics. The phytochemistry covers 8 major categories, 208 compounds in total, and the quantitative determination of 14 monomer compounds, total polyphenols and total flavonoids. The clinical trial in pregnant women and toxic experiments in mice, the pharmacology of 7 aspects and 82 frequently used prescriptions are summarized. It is expected that this paper will provide forward‐looking scientific thinking and literature support for the further modern research, development and utilization of COM.

Anti-obesity effect of Lactobacillus fermented Paeonia japonica, Cnidium officinale, and Angelica gigas nakai

“…Paeonia japonica (PJ) is a perennial plant belonging to the Apiaceae family that is found in Korea, Japan, China, and Sakhalin, and has a bitter and sour taste, which is beneficial to women's health and relieves pain by enriching blood, dissolving blood clots, and improving blood circulation (Ko et al, 2016;Lee et al, 2021). Cnidium officinale (CO) is a perennial plant belonging to the Apiaceae family that is spicy and warm, and removes blood clots to improve blood circulation and remove various inflammations and waste accumulated in the body (Bae et al, 2011;Ma et al, 2023). Angelica gigas nakai (AG) is a perennial plant belonging to the Apiaceae family, mainly found in Korea, Japan, and China, and has sweet, bitter and warm properties (Park et al, 2019;Zhang et al, 2012).…”