Proteinaceous Corneal Degeneration

Christensen, Gerald R.

doi:10.1001/archopht.1973.01000040032008

Cited by 17 publications

(2 citation statements)

References 3 publications

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“…(); 18: Garner et al. (); 19: Anderson & Fuglsang (); 20: Baquis (); 21: Sachsalber (); 22: Parsons (); 23: Kozlowski (); 24: Garner (); 25: Christensen (); 26: Brownstein et al. (); 27: Rodrigues et al.…”

Section: History Of the Diseasementioning

confidence: 99%

Climatic droplet keratopathy: an old disease in new clothes

Serra

Holopainen

Beuerman

et al. 2015

Acta Ophthalmologica

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ABSTRACT.Climatic droplet keratopathy (CDK) is an acquired and potentially handicapping cornea degenerative disease that is highly prevalent in certain rural communities around the world. It predominantly affects males over their forties. It has many other names such as Bietti's band-shaped nodular dystrophy, Labrador keratopathy, spheroidal degeneration, chronic actinic keratopathy, oil droplet degeneration, elastoid degeneration and keratinoid corneal degeneration. CDK is characterized by the haziness and opalescence of the cornea's most anterior layers which go through three stages with increasing severity. Globular deposits of different sizes may be histopathologically observed under the corneal epithelium by means of light and electron microscopy. The coalescence and increased volume of these spherules may cause the disruption of Bowman's membrane and the elevation and thinning of the corneal epithelium. The exact aetiology and pathogenesis of CDK are unknown, but they are possibly multifactorial. The only treatment in CDK advanced cases is a corneal transplantation, which in different impoverished regions of the world is not an available option. Many years ago, the clinical and histological aspects of this disease were described in several articles. This review highlights new scientific evidence of the expanding knowledge on CDK's pathogenesis which will open the prospect for new therapeutic interventions.

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Section: History Of the Diseasementioning

confidence: 99%

Climatic droplet keratopathy: an old disease in new clothes

Serra

Holopainen

Beuerman

et al. 2015

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…At least 12 English-language papers have described the light or electron microscopy of this condition. They included material from regions where external climatic factors appeared to be the main aetiological agent (Klintworth, 1972;D'Alena and Wood, 1972;Garner et al, 1973;Johnson and Ghosh, 1975), cases from temperate regions where no definite aetiology was proposed (Etzine and Kaufmann, 1964;Christensen, 1973;Garner et al, 1976), and cases of spheroidal degeneration in association with a corneal dystrophy (Garner, 1970), and in association with other intraocular disease and trauma Brownstein et al, 1973;Rodrigues et al, 1975;Cursino and Fine, 1976).…”

mentioning

confidence: 99%