Protein transduction by lipidic peptide dendrimers

Bayele, Henry K.; Ramaswamy, Chandrasekaran; Wilderspin, Andrew F.; Srai, K; Tóth, István; Florence, Alexander T.

doi:10.1002/jps.20606

Cited by 27 publications

(24 citation statements)

References 33 publications

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“…A few studies have also confirmed the delivery of therapeutic peptides and proteins using different conjugation techniques with dendrimers (Figs. 17B, C and D) [191–194]. However, targeted delivery of protein and peptide based biopharmaceuticals with dendrimers for ocular complications has not been reported so far.…”

Section: Novel Formulation Approaches For Ocular Delivery Of Protementioning

confidence: 99%

Ocular delivery of proteins and peptides: Challenges and novel formulation approaches

Mandal

Pal

Agrahari

et al. 2018

Advanced Drug Delivery Reviews

173

122

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The impact of proteins and peptides on the treatment of various conditions including ocular diseases over the past few decades has been advanced by substantial breakthroughs in structural biochemistry, genetic engineering, formulation and delivery approaches. Formulation and delivery of proteins and peptides, such as monoclonal antibodies, aptamers, recombinant proteins and peptides to ocular tissues poses significant challenges owing to their large size, poor permeation and susceptibility to degradation. A wide range of advanced drug delivery systems including polymeric controlled release systems, cell-based delivery and nanowafers are being exploited to overcome the challenges of frequent administration to ocular tissues. The next generation systems integrated with new delivery technologies are anticipated to generate improved efficacy and safety through the expansion of the therapeutic target space. This review will highlight recent advances in formulation and delivery strategies of protein and peptide based biopharmaceuticals. We will also describe the current state of proteins and peptides based ocular therapy and future therapeutic opportunities.

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Section: Novel Formulation Approaches For Ocular Delivery Of Protementioning

confidence: 99%

Ocular delivery of proteins and peptides: Challenges and novel formulation approaches

Mandal

Pal

Agrahari

et al. 2018

Advanced Drug Delivery Reviews

173

122

View full text Add to dashboard Cite

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“…Moreover, they can use small organic molecules and polymers as structural components, and thus acquire special physical and chemical properties. Up to now, dendrimers have been widely applied in many fields, such as supramolecular chemistry or host–guest chemistry,3, 4 electrochemistry,5 and photochemistry,6 nanoparticle synthesis,7–9 pollution management,10–12 dye decolorization,13, 14 preparation of monomolecular membranes,15–17 curing of epoxy resins,18, 19 catalysis,20–23 drug delivery,24–28 and gene transfection 29–31. Among them, the use of dendrimers in delivery systems has deserved more attentions in recent years 32, 33…”

Section: Introductionmentioning

confidence: 99%

Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration

Cheng

et al. 2008

Journal of Pharmaceutical Sciences

411

188

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“…Conjugation of neutral lipids (fatty acids, lipoamino acids and cholesterol) to delivery systems although not critical in aiding cellular internalization and transfection as demonstrated by the non-lipid containing PAMAM, PPI and PEI carriers, has been proven to be an effective strategy in overcoming the primary obstacles of cellular toxicity and poor transfection efficiency associated with their nonlipidic counterparts [40,[81][82][83][84][85]. A direct correlation between in vitro and in vivo effects of delivery systems is clearly not feasible due to the complexities of biological systems and in-part due to degradation caused by serum components such as albumin [86][87][88].…”

Section: Lipidic Dendrimersmentioning

confidence: 99%

The Advance of Dendrimers - A Versatile Targeting Platform for Gene/Drug Delivery

Parekh

2007

CPD

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The quest towards achieving a better understanding of underlying mechanisms by which genetic factors contribute to human disease has gathered considerable momentum, most notably due to the drafting of the complete human genome sequence. This has in turn accelerated research into identifying genes responsible for a plethora of genetic, infectious and metabolic diseases with the vision that therapies can then be developed. Although achieving a therapeutic intervention by gene delivery is perfectly feasible, the practical approach to achieving such a goal, at least in vivo, has proved far more challenging. Employing viruses as gene vectors has to-date proven to be the most effective method of delivery however concerns have emerged about both the short and long-term risks they pose. These fears being confirmed by incidents which led to the tragic deaths of subjects believed to have been triggered by adeno- & retroviral vectors used in clinical trials. This prompted many in the field to turn their research focus towards developing non-viral vectors deemed not only to be safer (non-immunogenic) than their viral counterparts but with a greater gene loading capacity. Polycationic dendrimers (PCDs) as vectors for this purpose have attracted significant interest due to their ease of synthesis, versatility and tolerability. This review will explore the physicochemical parameters crucial to PCD-mediated gene delivery and highlight some innovative strategies designed to maximise transfection efficacy and facilitate tissue-targeting of these elaborate macromolecules.

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Protein transduction by lipidic peptide dendrimers

Cited by 27 publications

References 33 publications

Ocular delivery of proteins and peptides: Challenges and novel formulation approaches

Ocular delivery of proteins and peptides: Challenges and novel formulation approaches

Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration

The Advance of Dendrimers - A Versatile Targeting Platform for Gene/Drug Delivery

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