Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration

Cheng, Yiyun; Xu, Zhenhua; Ma, Minglu; Xu, Tongwen

doi:10.1002/jps.21079

Cited by 409 publications

(203 citation statements)

References 117 publications

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“…Gerekli bölgede etken maddenin toplanabilmesini sağlamaya yetecek kadar süre vücutta kalabilmektedirler. Nanometre boyutlarında büyüklüğe sahip olmaları, zayıf damarlanmanın olduğu bölgelerde birikmelerine olanak sağlamaktadır (27)(28)(29)(30) (36,37). Lipozomlar, ilk olarak 60'ların ortasında tanımlan-mış, fosfolipid bazlı nanoveziküllerdir (38).…”

Section: İlaç Taşiyici Si̇stemler Olarak Nanotaşiyicilarunclassified

Malign plevral mezotelyomada ilaç taşıyıcı nanosistemler

Coşan¹,

Ak²,

Dag³

et al. 2016

Tuberk Toraks

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Section: İlaç Taşiyici Si̇stemler Olarak Nanotaşiyicilarunclassified

Malign plevral mezotelyomada ilaç taşıyıcı nanosistemler

Coşan¹,

Ak²,

Dag³

et al. 2016

Tuberk Toraks

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show abstract

“…Since the first nanoparticulate drug delivery systems as Liposome proposed in 1974 [21] lead to several breakthrough discoveries by using nanoparticles as drug carriers resulting from cutting-edge researches based on multidisciplinary approaches, many more applications have developed. Several research reports have been published on the applications of nanoparticulate drug delivery systems using various drug entities and polymers and different forms of drug delivery systems.…”

Section: Nanoparticulate Drug Delivery Systemmentioning

confidence: 99%

Shell-Nanostructured Materials for Biopharmacy and Biomedicine

Mirjanić¹,

Tomić-Šetrajčić²,

Šetrajčić³

2011

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Based on our research in ultrathin crystal structures performed so far, superlattices, Q-wires and Q-dots, we will consider the materials that can act as carriers for medicines and tagged substances. For this purpose we established a shell-model of ultrathin molecular crystals and investigated their dielectric, particularly optic characteristics. We conducted this research with the help of two-time dependent Green's function method, adjusted to ultrathin crystalline structure analysis. It is shown that specific resonant absorption lines appear in these structures, the number of which depends on crystal layers position and on values of parameters on shell-structure boundary surfaces. The absorption of electromagnetic radiation declines in infrared part and its detection is a relatively easy process.In this paper we will analyze application of nanomaterials in biomedicine, that is to say we will present the recent accomplishments in basic and clinical nanomedicine. Achieving full potential of nanomedicine may be years of even decades away, however, potential advances in drug delivery, diagnosis, and development of nanotechnology-related drugs start to change the landscape of medicine. Site-specific targeted drug delivery (made possible by the availability of unique delivery platforms, such as dendrimers, nanoparticles and nanoliposomes) and personalized medicine (result of the advance in pharmacogenetics) are just a few concepts on the horizon of research. In this paper, especially, we have analyzed the changes in basic physical properties of spherical-shaped nanoparticles that can be made in several (nano)layers and have, at the same time, multiple applications in medicine.

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“…Among all dendrimers, citric acid dendrimers are popular and easy to synthesize. They have been considered as vehicles for different routes of delivery such as oral, Transdermal, ocular, i.v etc (Cheng et al, 2008). Considering the use of dendrimers for drug delivery, it should be noted that they are bio-compatible, non-toxic (Jain et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Novel Citric Acid Dendritic Hydrogels for the Delivery of Econazole Nitrate and its Antifungal Activity

Rao¹,

Fathima²,

Viswanath³

et al. 2016

J App Pharm Sci

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Econazole is an imidazole derivative antifungal drug with distinguished antifungal properties. But the bioavailability of conventional econazole preparations is poor because of poor solubility and lipophilicity or lipophilic nature. Thus frequent application of the preparation is required to maintain therapeutic levels at the site of action. Such repeated doses may produce toxic affects thereby limiting the clinical use of the drug. Citric acid dendrimers give an opportunity to overcome the above limitations by improving its solubilization and drug permeation properties. Thus, the aim of current study is to design citric acid dendrimer hydrogels and study its influence on the drug release and anti-fungal activity of loaded drug. Dendritic architecture and size strongly influences the invitro release and antifungal activity of drug. Antifungal activity of designed Econazole hydrogel was measured by Agar plate diffusion method. Zone of inhibition values showed that citric acid dendrimers considerably enhanced the antifungal activity of Econazole to a greater extent and the effect was more with lower generation hydrogels. The operative mechanism is probably the smaller size (G2) that penetrates the fungal cell membrane more efficiently than higher generation (G3 and G4) hydrogels.

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Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration

Cited by 409 publications

References 117 publications

Malign plevral mezotelyomada ilaç taşıyıcı nanosistemler

Malign plevral mezotelyomada ilaç taşıyıcı nanosistemler

Shell-Nanostructured Materials for Biopharmacy and Biomedicine

Novel Citric Acid Dendritic Hydrogels for the Delivery of Econazole Nitrate and its Antifungal Activity

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