Econazole is an imidazole derivative antifungal drug with distinguished antifungal properties. But the bioavailability of conventional econazole preparations is poor because of poor solubility and lipophilicity or lipophilic nature. Thus frequent application of the preparation is required to maintain therapeutic levels at the site of action. Such repeated doses may produce toxic affects thereby limiting the clinical use of the drug. Citric acid dendrimers give an opportunity to overcome the above limitations by improving its solubilization and drug permeation properties. Thus, the aim of current study is to design citric acid dendrimer hydrogels and study its influence on the drug release and anti-fungal activity of loaded drug. Dendritic architecture and size strongly influences the invitro release and antifungal activity of drug. Antifungal activity of designed Econazole hydrogel was measured by Agar plate diffusion method. Zone of inhibition values showed that citric acid dendrimers considerably enhanced the antifungal activity of Econazole to a greater extent and the effect was more with lower generation hydrogels. The operative mechanism is probably the smaller size (G2) that penetrates the fungal cell membrane more efficiently than higher generation (G3 and G4) hydrogels.
Whole blood is the red fluid constantly circulating in our blood vessels (arteries and veins) in order to supply nutrition and oxygen to the body and removal of waste substances. This fluid consists of numerous cells (erythrocytes, leukocytes and platelets) and proteins suspended in the plasma. Blood has three main functions: transportation, regulation and protection. There is no substitute for blood and cannot be manufactured. Blood loss is controlled by clotting factors present and white blood cells provide immune response. Thus, blood cells play vital role in normal functioning of human body. It is the purpose of this review to describe the types and role of blood cells in human body and brief description of leukocyte culture.
The aim of the study was to develop 5-FU loaded pH and thermo-sensitive nanogels that could specifically respond to tumour endosomal pH and extracellular pH, while being dormant to physiological pH at physiological temperature.
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