Protein Toxins from Bordetella pertussis

Muñoz, J.

doi:10.1016/b978-0-12-046502-6.50013-7

Cited by 18 publications

(14 citation statements)

References 152 publications

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“…To summarize, histamine sensitization in mice in response to B. pertussis infection was first described over 50 years ago (606). Subsequently, histamine sensitization was studied by many investigators, but only five studies involving humans were carried out (269,486,501,561,574,576,618,622,625,686,701,801). In a 1948 study, Parfentjev and Goodline found that mice injected intraperitoneally with a pertussis vaccine subsequently became hypersensitive to histamine challenge; 2 mg of histamine had similar lethality in sensitized (previously vaccinated) mice as did 50 mg in unvaccinated mice (606).…”

Section: Virulence Determinantsmentioning

confidence: 99%

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants, pathogenesis, and immunity of Bordetella. Clinically, the full spectrum of disease due to B. pertussis infection is now understood, and infections in adolescents and adults are recognized as the reservoir for cyclic outbreaks of disease. DTaP vaccines, which are less reactogenic than DTP vaccines, are now in general use in many developed countries, and it is expected that the expansion of their use to adolescents and adults will have a significant impact on reducing pertussis and perhaps decrease the circulation of B. pertussis. Future studies should seek to determine the cause of the unique cough which is associated with Bordetella respiratory infections. It is also hoped that data gathered from molecular Bordetella research will lead to a new generation of DTaP vaccines which provide greater efficacy than is provided by today's vaccines

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Section: Virulence Determinantsmentioning

confidence: 99%

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

2005

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“…In a review on the treatment of whooping cough, Broomhall and Herxheimer (1 984) suggested that carefully designed clinical trials should be set up in which several forms of treatment, including corticosteroids, could be assessed. If HLT has an important role in the pathogenesis of pertussis, as seems possible (Munoz, 1971;Olson, 1975;Wardlaw and Parton, 1983), the present work suggests that non-steroidal anti-inflammatory agents also may be worthy of investigation. Further studies on the effects of a range of anti-inflammatory agents on the various pathophysiological activities of B. pertussis toxins in mice could help in the selection of the most likely candidates.…”

Section: Discussionmentioning

confidence: 97%

“…However, the marked effects seen in laboratory animals after injection of HLT strongly suggest that it has a significant part in the disease process (Munoz, 1971;Olson, 1975;Wardlaw and Parton, 1983). Recently, it was shown that prednisolone, given orally or ip before chal- Received 17 Jun.…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism of action of HLT is unknown but it is lethal when given intraperitoneally (ip) or intravenously to mice, guinea pigs or rabbits. When injected subcutaneously (sc) or intracutaneously (ic) into various experimental animals it causes haemorrhage and necrosis (Munoz, 1971). A sensitive method for detecting HLT activity is by injecting it sc or ic into suckling mice and scoring the haemorrhagic reaction after 2 4 4 8 h (Katsampes et al, 1942;Kurokawa et al, 1969;Cowell et al, 1979;Livey and Wardlaw, 1984).…”

Section: Introductionmentioning

confidence: 99%

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Effect of anti-inflammatory agents on the haemorrhagic response of mouse skin to Bordetella pertussis heat-labile toxin

Parton

1986

Journal of Medical Microbiology

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“…Both can occur in one of several phases (Leslie and Gardner, 1931;Nakase, 1957a;Ezzell et al, 1981) and the importance of using "smooth" or phase-I variants for studies of virulence in laboratory animals has been emphasised. Furthermore, disrupted cell preparations of B. pertussis and B. bronchiseptica contain a heat-labile toxin that is lethal for mice (Munoz, 1971;Morse, 1976). In pigs, Hanada et al (1979) showed that turbinate atrophy could be produced by the repeated intranasal instillation of cell-free material prepared from a phase4 strain of B. bronchiseptica by ultrasonic disintegration.…”

Section: Introductionmentioning

confidence: 99%

Virulence of Bordetella Bronchiseptica in the Porcine Respiratory Tract

Collings

Rutter

1985

Journal of Medical Microbiology

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SUMMARY.The virulence of Bordetella bronchiseptica in gnotobiotic piglets was studied by intranasal infection with 11 cultures derived from eight strains isolated from pigs (4), dogs (2), a human subject and a monkey. Six of the cultures contained organisms in phase I and five contained phenotypically different phase-I11 or -1V organisms. Of the phase-I11 and -1V cultures, four were derived from strains that had been isolated in phase I. Colonisation of the nasal cavity was investigated by counting bacteria in nasal swabs and washings. The toxigenicity of cell extracts from each strain and variant was determined by tests of lethality in mice or of cytopathogenicity in cell cultures. The results showed that two phase-I cultures from pigs colonised the nasal cavity and respiratory tract of gnotobiotic piglets better than did four phase-I cultures from other species. Phase-I organisms invariably produced capsules, fimbriae and mannose-resistant haemagglutination of guinea-pig erythrocytes. Four of five cultures in phases I11 and IV consisted of organisms that did not produce capsules, fimbriae or haemagglutination and colonised the nasal cavity poorly. Phase variation from I to I11 occurred in culture and in vivo, but variation from I11 to I occurred in vivo only and was accompanied by enhanced colonisation. Gnotobiotic piglets infected with porcine phase-I organisms exhibited atrophy of the nasal turbinate bones after 28 days; these organisms produced significantly more toxin than did bacteria in phase I from other species, or those in phases 111 and IV. It was concluded that the development of turbinate atrophy was associated with (1) the ability to produce heavy, persistent colonisation in the nasal cavity, and (2) the production of a heat-labile toxin. Only the two porcine phase-I cultures possessed both properties.

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Protein Toxins from Bordetella pertussis

Cited by 18 publications

References 152 publications

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due toBordetella pertussisand OtherBordetellaSubspecies

Effect of anti-inflammatory agents on the haemorrhagic response of mouse skin to Bordetella pertussis heat-labile toxin

Virulence of Bordetella Bronchiseptica in the Porcine Respiratory Tract

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