Protein Synthesis-Independent Plasticity Mediates Rapid and Precise Recovery of Deprived Eye Responses

Krahe, Thomas E.; Medina, Alexandre E.; Bittencourt-Navarrete, Ruben Ernesto; Colello, Raymond J.; Ramoa, Ary S.

doi:10.1016/j.neuron.2005.09.016

Cited by 31 publications

(32 citation statements)

References 52 publications

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“…Furthermore, H-ras G12V expression is unique in accelerating both deprivation-induced plasticity and recovery from deprivation. Previous studies have shown that these two processes differ mechanistically, involving distinct cellular processes (8,30,31). H-ras is known to initiate signaling pathways leading to activation of distinct sets of effector molecules depending on cellular conditions (15), consistent with our finding that constitutive activation of H-ras affects plasticity both during MD and during recovery from deprivation.…”

Section: Discussion Acceleration Of Multiple Forms Of Visual Cortex Psupporting

confidence: 90%

Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex

Kaneko

Cheetham

Lee

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Experience-dependent cortical plasticity has been studied by using loss-of-function methods. Here, we take the complementary approach of using a genetic gain-of-function that enhances plasticity. We show that a constitutively active form of H-ras (H-ras G12V ), expressed presynaptically at excitatory synapses in mice, accelerates and enhances multiple, mechanistically distinct forms of plasticity in the developing visual cortex. In vivo, H-ras G12V not only increased the rate of ocular dominance change in response to monocular deprivation (MD), but also accelerated recovery from deprivation by reverse occlusion. In vitro, H-ras G12V expression decreased baseline presynaptic release probability and enhanced presynaptically expressed longterm potentiation (LTP). H-ras G12V expression also accelerated the increase following MD in the frequency of miniature excitatory potentials, mirroring accelerated plasticity in vivo. These findings demonstrate accelerated neocortical plasticity, which offers an avenue toward future therapies for many neurological and neuropsychiatric disorders.gain of function | monocular deprivation | mouse | ocular dominance | presynaptic long-term potentiation

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Section: Discussion Acceleration Of Multiple Forms Of Visual Cortex Psupporting

confidence: 90%

Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex

Kaneko

Cheetham

Lee

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…Optical imaging of intrinsic signals was performed with Imager 2001 VSDϩ (Optical Imaging System, Germantown, NY) by using imaging methods slightly modified from those described previously (Medina et al, 2003;Krahe et al, 2005). Briefly, animals were premedicated, anesthetized, and ventilated with similar procedures described for single-unit recordings.…”

Section: Methodsmentioning

confidence: 99%

“…The approximate location of the border between V1 and V2 was still distinguishable after 3 d of monocular deprivation (MD). However, longer periods of MD lead to saturating left eye dominance in V1/V2, making this distinction more difficult (Krahe et al, 2005). After defining the ROI, we created ocular dominance histograms based on the range of gray values (0 -255) divided into five class intervals, where 0 -50 and 204 -255 correspond to classes containing the darkest and lightest pixels, respectively.…”

Section: Methodsmentioning

confidence: 99%

Restoration of Neuronal Plasticity by a Phosphodiesterase Type 1 Inhibitor in a Model of Fetal Alcohol Exposure

Medina¹,

Krahe²,

Ramoa³

2006

J. Neurosci.

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Although some studies showed the efficacy of phosphodiesterase (PDE) inhibitors as neuronal plasticity enhancers, little is known about the effectiveness of these drugs to improve plasticity in cases of mental retardation. Fetal alcohol syndrome (FAS) is the leading cause of mental retardation in the western world. Using a combination of electrophysiological and optical imaging techniques, we show here that vinpocetine, a PDE type I inhibitor, restores ocular dominance plasticity in the ferret model of fetal alcohol exposure. Our finding should contribute to a better understanding and treatment of cognitive deficits associated with mental disorders, such as FAS.

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“…A number of studies show that ipsilateral eye pathways are differentially affected by monocular deprivation (Antonini et al 1999;Krahe et al 2005;Tagawa et al 2005). In light of these studies, we examined the effects of visual manipulation on ipsilateral eye cortical maps.…”

Section: Plasticity Of Ipsilateral Eye Mapsmentioning

confidence: 99%

Ipsilateral Eye Cortical Maps Are Uniquely Sensitive to Binocular Plasticity

Faguet¹,

Maranhao

Smith

et al. 2009

Journal of Neurophysiology

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Faguet J, Maranhao B, Smith SL, Trachtenberg JT. Ipsilateral eye cortical maps are uniquely sensitive to binocular plasticity. J Neurophysiol 101: 855-861, 2009. First published December 3, 2008 doi:10.1152/jn.90893.2008. In the cerebral cortex, neuronal circuits are first laid down by intrinsic mechanisms and then refined by experience. In the canonical model, this refinement is driven by activity-dependent competition between inputs for some limited cortical resource. Here we examine this idea in the mouse visual cortex at the peak of the critical period for experience-dependent plasticity. By imaging intrinsic optical responses, we mapped the strength and size of each eye's cortical representation in normal mice, mice that had been deprived of patterned vision uni-or bilaterally, and in mice in which the contralateral eye had been removed. We find that for both eyes, a period of visual deprivation results in a loss of cortical responsiveness to stimulation through the deprived eye. In addition, the ipsilateral eye pathway is affected by the quality of vision through the opposite eye. Our findings indicate that although both contra-and ipsilateral eye pathways require visual experience for their maintenance, ipsilateral eye projections bear an additional, unique sensitivity to binocular interactions.

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Protein Synthesis-Independent Plasticity Mediates Rapid and Precise Recovery of Deprived Eye Responses

Cited by 31 publications

References 52 publications

Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex

Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex

Restoration of Neuronal Plasticity by a Phosphodiesterase Type 1 Inhibitor in a Model of Fetal Alcohol Exposure

Ipsilateral Eye Cortical Maps Are Uniquely Sensitive to Binocular Plasticity

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