Protein S and HIV infection the role of anticardiolipin and anti-protein S antibodies

Pseudotumour cerebri after varicella

“…The role of streptococcal co-infection or anticardiolipin antibodies remain unclear [11]. Anticardiolipin antibodies seem to lower protein S levels and therefore may aggravate the protein S de®ciency due to protein S auto-antibody [11]. The coagulation status of our patient 6 months later showed no abnormalities except for somewhat low protein S and protein C values which cannot be evaluated under oral anticoagulation therapy.…”

“…Protein S auto-antibodies resulting in transient protein S de®ciency seem to be the causative agent of thrombotic complications after chickenpox. The role of streptococcal co-infection or anticardiolipin antibodies remain unclear [11]. Anticardiolipin antibodies seem to lower protein S levels and therefore may aggravate the protein S de®ciency due to protein S auto-antibody [11].…”

Osteonecrosis in patients with acquired immunodeficiency syndrome (AIDS): report of two cases and review of the literature

“…Our patient 2 did not have anticardiolipin antibodies, and patient 1 was not tested. The acquired deficiency of protein S, a natural antithrombotic factor, may play a role in the osteonecrosis of these patients since HIV-infection is associated with this condition and with the presence of anti-protein S antibodies (11).…”

Diagnostic du déficit en protéine S

“…Ainsi certains patients développent des anticorps dirigés contre la PS, soit dans le cadre d'un syndrome des antiphospholipides [38], soit au décours de certaines infections, en particulier du VZV responsable de la varicelle [33], ou du VIH [37,39]. Les cas de varicelle rapportés avec de tels anticorps décrivent des taux de PS très diminués et une symptomatologie sévère, souvent similaire à celle du déficit homozygote en PS.…”