Protein release from physically crosslinked hydrogels of the PLA/PEO/PLA triblock copolymer-type

Molina, Inmaculada; Li, Suming; Martı́nez, Manuel Bueno; Vert, Michel

doi:10.1016/s0142-9612(00)00192-7

Cited by 154 publications

(100 citation statements)

References 16 publications

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“…28 The results obtained in the drug release and amoxicillin protective characterization study suggest that this new polyionic complex (PAA:CS:A 2.5:5:2) would maintain an effective concentration of amoxicillin in SGF (pH 1.2) at least for 3 h, which could be of outmost importance for H. pylori treatment. Therefore, this network with the higher polymer density was selected to evaluate its gastric-emptying time in healthy volunteers.…”

Section: In Vitro Amoxicillin Releasementioning

confidence: 87%

Poly (acrylic acid) chitosan interpolymer complexes for stomach controlled antibiotic delivery

2004

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The aim of this study was to develop a stomach-specific drug delivery system to increase the efficacy of amoxicillin against Helicobacter pylori. Polyacrylic acid (PAA), chitosan (CS), and amoxicillin (A) were employed to obtain polyionic complexes. The design of the hydrogel delivery system was based on the swellable approach; with a floating feature to prolong the Gastric Residence Time (GRT). The polyionic complex (PAA:CS:A 2.5:5:2) showed a sustained drug release profile in enzyme-free simulated gastric fluid (SGF) and pH 4.0. A pH independent swelling-eroding pattern with adequate maximum swelling ratios of 17.76 and 13.42 was obtained at in SGF and pH 4.0, respectively, with similar eroding profiles in both pH media. This network carrier provides an amoxicillin protective effect towards the hydrolytic degradation in SGF. The in vivo study was performed on healthy volunteers, using the [ 13 C] octanoic acid breath test. The proposed hydrogel showed a prolonged GRT of up to 3 h. The preliminary results from this study suggest that amoxicillin polyionic complexes have potential for improving local antibiotic therapy against H. pylori.

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Section: In Vitro Amoxicillin Releasementioning

confidence: 87%

Poly (acrylic acid) chitosan interpolymer complexes for stomach controlled antibiotic delivery

2004

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“…These local deliveries were shown to result in marked reductions of postoperative adhesions, while enabling low systemic dosing with the enzymes. Recently, Molina et al (2001) have illustrated that the release kinetics of proteins from physically crosslinked poly(lactic acid)\ poly(ethylene oxide) hydrogels depends greatly on the compatibility of the gel and protein. This was highlighted by the compatible BSA-hydrogel system resulting in a concentration-dependent protein release, whereas the gel network created a reservoir-type release for the phase-separating substrate fibrinogen.…”

Section: Hydrogel Systemsmentioning

confidence: 99%

Growth factor release from tissue engineering scaffolds

Whitaker

Quirk

Howdle

et al. 2001

Journal of Pharmacy and Pharmacology

258

160

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Synthetic scaffold materials are used in tissue engineering for a variety of applications, including physical supports for the creation of functional tissues, protective gels to aid in wound healing and to encapsulate cells for localized hormone-delivery therapies. In order to encourage successful tissue growth, these scaffold materials must incorporate vital growth factors that are released to control their development. A major challenge lies in the requirement for these growth factor delivery mechanisms to mimic the in-vivo release profiles of factors produced during natural tissue morphogenesis or repair. This review highlights some of the major strategies for creating scaffold constructs reported thus far, along with the approaches taken to incorporate growth factors within the materials and the benefits of combining tissue engineering and drug delivery expertise.

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“…As a typical soft matter, polymer gels have attracted increasing attention with respect to fundamental research and their applications in the fields of biosensors, [1,2] drug delivery, [3,4] bioseparations, [5,6] tissue engineering [7,8] and smart devices. [9,10] New applications also call for many new requirements concerning their mechanical properties, transparency, environmental sensitivity and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

High‐Strength Cellulose/Poly(ethylene glycol) Gels

Liang

Tian

et al. 2008

ChemSusChem

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Cellulose gel membranes have been prepared by a pre-gelation method employing cellulose solutions in aqueous NaOH-thiourea obtained at low temperature. The cellulose gels were then swollen by low-molecular-weight polyethylene glycol (PEG; MW<1000 g mol(-1)), and the morphology, structure and mechanical properties of the cellulose/PEG gels were studied by various techniques. The gels exhibit high mechanical performance, and the tensile strength of the gel membranes increases sharply with an increase in the molecular weight of PEG from 200 to 800 g mol(-1). Moreover, their elongation at break remains stable at 100 %. PEG800 efficiently improves the optical transmittance of the gel membranes at ambient temperature, which is about five times greater than that of a normal cellulose hydrogel membrane. A strong hydrogen-bonding interaction occurs between PEG and cellulose leading to a homogeneous structure, high mechanical strength and good transparency of the gel membranes.

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Protein release from physically crosslinked hydrogels of the PLA/PEO/PLA triblock copolymer-type

Cited by 154 publications

References 16 publications

Poly (acrylic acid) chitosan interpolymer complexes for stomach controlled antibiotic delivery

Poly (acrylic acid) chitosan interpolymer complexes for stomach controlled antibiotic delivery

Growth factor release from tissue engineering scaffolds

High‐Strength Cellulose/Poly(ethylene glycol) Gels

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