Protein regulator of cytokinesis-1 expression: prognostic value in lung squamous cell carcinoma patients

Abstract

Background: Protein regulator of cytokinesis-1 (PRC1) has been shown to participate in the completion of cytokinesis, and it is dysregulated in cancer processes. However, its relevance in lung squamous cell carcinoma (SCC) remained largely unknown. We aimed to study the expression pattern of PRC1 and assess its clinical significance in lung SCC.Methods: PRC1 protein expression in human lung SCC and adjacent normal lung tissues was detected by immunohistochemistry. PRC1 expression was assessed in association with clinicopathological features and clinical outcomes of lung SCC patients. Results: In lung SCC tissues, PRC1 protein expression was significantly higher than those in paired normal lung tissues. The lung SCC patients with PRC1 overexpression had an advanced pathological stage (TNM stage), positive lymph node metastasis, and a shorter overall survival (OS) time more frequently than patients with low PRC1 expression. Additional, PRC1 expression was also shown to be poor as a prognostic factor for OS in patients with lung SCC. Conclusions: Our study indicated that aberrant expression of PRC1 may point to biochemical recurrence in lung SCC. This highlights its potential as a valuable prognostic marker for lung SCC.

Comprehensive analysis of key genes associated with ceRNA networks in nasopharyngeal carcinoma based on bioinformatics analysis

“…For example, the study of Wang et al has revealed that lncRNA HCP5 may promote the malignant behavior of ovarian cancer cells by miR-525-5p/PRC1 crosstalk and Wnt/β-catenin pathway [60]. PRC1 has been associated with many malignant carcinomas, such as NPC [61], prostate cancer [62], and lung cancer [63]. In vitro experiments have shown that PRC1 depletion inhibits the multiplication and invasiveness of NPC, while in vivo studies have found that PRC1 inhibits the neoplasia and radioresistance of NPC [61].…”

Regulation of proliferation and cell cycle by protein regulator of cytokinesis 1 in oral squamous cell carcinoma

“…Furthermore, G2/M cell cycle arrest could result in the inhibition of cell proliferation 1 . Previous studies have shown that some cancer cells are highly dependent on PRC1 for proliferation 29 , 30 . For instance, Shimo et al 18 found that intervention with siRNA against PRC1 in breast cancer cells effectively suppressed its expression and inhibited the proliferation of the cells.…”

Mechanisms of the Ase1/PRC1/MAP65 family in central spindle assembly

“…The overexpression of PRC1 can lead to cytokinesis failure and chromosomal instability, further stimulating aneuploidy and tumorigenesis. High expression of PRC1 is closely associated with several phenotypes in diverse tumours: poor differentiation, large tumour size and high clinical grade in oral squamous cell carcinomas (Wu et al, ), lymph node metastasis and poor prognosis in lung adenocarcinoma patients (Zhan et al, ), the early recurrence of hepatocellular carcinoma (Chen et al, ), chemoresistance to 5‐florouracil and Taxol, and lower survival rate of hepatocellular carcinoma patients (Wang et al, ; Liu et al, ) (Table ).…”

“…PRC1 ablation leads to G2/M phase arrest in lung adenocarcinoma (Zhan et al, ) and oral squamous cell carcinomas (Wu et al, ), but the mechanism remains unclear. PRC1 also blocks mitotic exit of hepatocellular carcinoma cells at telophase in a spindle assembly checkpoint‐independent manner involving a tumor‐suppressor p53‐dependent pathway (Liu et al, ).…”

“…PRC1 is a downstream target of the canonical int/Wingless 3a (Wnt3a)/β‐catenin pathway during cancer proliferation, metastasis and tumorigenesis (Chen et al, ; Zhan et al, ). PRC1 expression and cytoskeletal distribution is controlled by Wnt signalling.…”