Protein-reduced gold nanoparticles mixed with gentamicin sulfate and loaded into konjac/gelatin sponge heal wounds and kill drug-resistant bacteria

Zou, Yini; Xie, Ruiqi; Hu, Enling; Qian, Ping; Lu, Bitao; Lan, Guangqian; Lu, Fei

doi:10.1016/j.ijbiomac.2020.01.190

Cited by 59 publications

(19 citation statements)

References 47 publications

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“…The abovementioned results show that the release of • OH in CuO 2 is pH-dependent (Figure S3), which is consistent with the results reported by Lin et al 14 Gelatin has good biocompatibility, biodegradability, 41 and low antigenicity 42 and has properties similar to those of collagen; it is easy to modify. 43 Therefore, gelatin has been used in drug delivery carriers 44,45 and tissue repair engineering. In order to reduce the infiltration of wound exudate to the surrounding tissues and use easily, we first load different contents of Cu(OH) 2 on the GS to obtain the GS-Cu(OH) 2 dressing and then react it with H 2 O 2 to obtain the GS-CuO 2 dressing (Figure 2A).…”

Section: Resultsmentioning

confidence: 99%

Copper Peroxide-Loaded Gelatin Sponges for Wound Dressings with Antimicrobial and Accelerating Healing Properties

Cui

Liu

et al. 2021

ACS Appl. Mater. Interfaces

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Catalytic conversion of hydrogen peroxide (H2O2) to more toxic hydroxyl radicals (•OH) is a good choice for sterilization and anti-infection, but endogenous H2O2 is insufficient to achieve satisfactory sterilization efficacy. Despite great efforts, designing and developing antimicrobial materials that specifically and effectively self-supply H2O2 at the wound site remain as tremendous challenges. Here, we report a pH-responsive copper peroxide-loaded wound dressing made from copper hydroxide and gelatin sponge and then reacted with H2O2. In vitro experiments show that the prepared wound dressing has good bactericidal properties against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Pseudomonas aeruginosa (P. aeruginosa). Moreover, the as-prepared wound dressing can release •OH specifically in the bacterial-infected skin wound, rather than in normal tissues, and in vivo skin wound-healing experiments proved that the synthesized copper peroxide-loaded gelatin sponge could combat E. coli effectively; in addition, Cu2+ released from the gelatin sponge could stimulate angiogenesis and collagen deposition simultaneously. The study provides a strategy to improve antibacterial efficacy and reduce the toxic side effects through the release of •OH by bacterial self-activation.

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Section: Resultsmentioning

confidence: 99%

Copper Peroxide-Loaded Gelatin Sponges for Wound Dressings with Antimicrobial and Accelerating Healing Properties

Cui

Liu

et al. 2021

ACS Appl. Mater. Interfaces

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“…Gelatin is one of the biopolymers widely reported for the preparation of sponges (Table 3). Zou et al, reported gelatin-konjac glucomannan hybrid sponges loaded with gold (Au) nanoparticles and gentamicin sulfate for the treatment of bacteria-infected wounds [66]. The transmission electron microscope (TEM) images displayed the shape of Au nanoparticles which was spherical or elliptical in a single dispersed modality with an average particle size of 3.55 ± 0.26 nm.…”

Section: Spongesmentioning

confidence: 99%

“…The in vitro antimicrobial experiments demonstrated that the dual drug-loaded sponges possessed higher antibacterial efficacy against E. coli , S. aureus , and MRSA while the plain hybrid sponges did not possess any antibacterial effect against these bacterial strains. The in vivo studies using the rabbit model showed that the full thickness wounds dressed with dual drug-loaded hybrid sponges were almost completely healed on day 14 when compared to other groups [ 66 ].…”

Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.

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“…The results showed that the combined application of GS and AuNPs had significantly better antibacterial effect than AuNPs or AuNPs alone, which could effectively remove superbacteria, inhibit bacterial growth and promote wound healing. 140 …”

Section: Effects Of Nanoparticles On Wound Healingmentioning

confidence: 99%

How Effective are Nano-Based Dressings in Diabetic Wound Healing? A Comprehensive Review of Literature

Wang¹,

Zhang²,

Li³

et al. 2022

IJN

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Chronic wound caused by diabetes is an important cause of disability and seriously affects the quality of life of patients. Therefore, it is of great clinical significance to develop a wound dressing that can accelerate the healing of diabetic wounds. Nanoparticles have great advantages in promoting diabetic wound healing due to their antibacterial properties, low cytotoxicity, good biocompatibility and drug delivery ability. Adding nanoparticles to the dressing matrix and using nanoparticles to deliver drugs and cytokines to promote wound healing has proven to be effective. This review will focus on the effects of diabetes on wound healing, introduce the properties, preparation methods and action mechanism of nanoparticles in wound healing, and describe the effects and application status of various nanoparticle-loaded dressings in diabetes-related chronic wound healing.

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Protein-reduced gold nanoparticles mixed with gentamicin sulfate and loaded into konjac/gelatin sponge heal wounds and kill drug-resistant bacteria

Cited by 59 publications

References 47 publications

Copper Peroxide-Loaded Gelatin Sponges for Wound Dressings with Antimicrobial and Accelerating Healing Properties

Copper Peroxide-Loaded Gelatin Sponges for Wound Dressings with Antimicrobial and Accelerating Healing Properties

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

How Effective are Nano-Based Dressings in Diabetic Wound Healing? A Comprehensive Review of Literature

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