Protein−Polymer Nanoparticles for Nonviral Gene Delivery

Zhang, Jianjun; Lei, Yu; Dhaliwal, Anandika; Ng, Quinn K. T.; Du, Juanjuan; Yan, Ming; Lu, Yunfeng; Segura, Tatiana

doi:10.1021/bm101354a

Cited by 40 publications

(31 citation statements)

References 53 publications

(92 reference statements)

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“…In general, we observed advantages of such hybrid systems over their respective traditional DDS, which significantly improved the in vivo pharmacokinetics and the activity of several classes of drugs [67,72,100,104,118,119,128]. As in the case of protein nanoparticles, where polymer-protein conjugates for gene delivery provided biofunctionality to the systems [57], other formulations reduced in vivo tumor growth [56]; and the anti-inflammatory activity five times higher than the traditional protein nanoparticle was noticed [58]. Regarding the hybrid lipid-based DDS, the outlook is exciting.…”

Section: In Vivo Performance Of Biohybrid Polymer-based Hybrid Ddsmentioning

confidence: 91%

“…The camptothecin-loaded BSA-PMMA nanoparticles showed antitumor activity improvement in both in vitro and in vivo studies, reducing the tumor growth around 79%, being more effective than free drug. Zhang et al described another biohybrid polymer-protein system as a delivery vector for nonviral genes [57]. Nanoparticles of BSApoly(dimethylamino)ethyl methacrylate (nBSA) were synthesized by in situ polymerization, with BSA as the macroinitiator.…”

Section: Polymer-protein Nanoparticles Formulationsmentioning

confidence: 99%

“…The nBSA/pDNA conjugates were able to transfer genes to cells with similar or improved efficiency compared to the PEI and PDMA polymers. It is believed that the use of polymer-protein conjugates for gene delivery provides additional biofunctionality to the systems [57].…”

Section: Polymer-protein Nanoparticles Formulationsmentioning

confidence: 99%

“…Figure 2 compares the structure of some types of traditional DDS and the respective hybrid systems. Table 2 shows relevant information of main published works International Journal of Polymer Science 9 Emulgel-jojoba oil/HPMC Clotrimazole - [46] Emulgel-xanthan gum Acyclovir and ketoconazole - [47] Emulgel-lecithin soy Ketoprofen - [113] Nanogel-agar Sodium diclofenac - [48] Emulgel-CMC Sodium diclofenac - [114] Emulgel-gelatin Metronidazole - [45] Poly(SMA)-neocarzinostatin Neocarzinostatin - [115] PEG-DNA DNA - [52] PEG-streptavidin Streptavidin - [116] PEG-L-asparaginase L-Asparaginase - [53] PEG-streptavidin Streptavidin - [117] PDMA-BSA DNA - [57] PMMA-BSA Camptothecin 11.0% [56] ELP-FKBP Rapamycin - [58] Liposome-chitosan Doxorubicin 98.0 % [78] Liposome-cellulose Quercetin 40.0% [77] Liposome-cellulose Rutin 58.0% [77] Liposome-gel Lidocaine 21.6% [118] Liposome-gel Bupivacaine 98.8% [119] Liposome-alginate Benzocaine 63.2% [120] Liposome-PEG Lidocaine 98.8% [73] Cyclodextrin/liposome Quercetin 91.0% [121] Cyclodextrin/liposome Tretinoin 88.7% [122] Cyclodextrin/liposome Curcumin 50.0% [123] Cyclodextrin/PLGA Oxaprozin 62.0% [124] SLN-PLGA-PEG-PLGA [112] related to biohybrid systems for sustained delivery of therapeutic molecules.…”

Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

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Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

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Section: In Vivo Performance Of Biohybrid Polymer-based Hybrid Ddsmentioning

confidence: 91%

Section: Polymer-protein Nanoparticles Formulationsmentioning

confidence: 99%

Section: Polymer-protein Nanoparticles Formulationsmentioning

confidence: 99%

Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

See 2 more Smart Citations

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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“…Earlier, the viral vectors were used to carry genes to the target organism but the use of viral vectors possesses certain limitations. Compared to viral gene delivery approaches, non-viral gene delivery systems have the supplementary advantages of being less immunogenic, ability to incorporate larger genes, easy and inexpensive to produce at large scale in relation to viral systems (Zhang et al 2011). The overall ability of NPs to function as non-viral gene delivery vectors depends upon certain factors like properties of NPs such as shape, size, morphology and surface charge (Khalil et al 2006).…”

Section: Gene Therapymentioning

confidence: 99%

Metallic Nanoparticles, Toxicity Issues and Applications in Medicine

Singla

Guliani

Kumari

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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The metallic nanoparticles (NPs) and their synthetic biology are an active area fascinating both the academics as well as scientific research applications in the field of nanotechnology. These nanostructures are a versatile class of materials such as metal NPs, metal oxide NPs, magnetic NPs and quantum dots for biomedical sciences and engineering due to their huge potential. A handful number of methods are adopted for the synthesis of one or the other kind of metal NPs which includes physical and chemical approaches. Each of the chemical and physical synthesis procedures deals with some limitations such as cost ineffectiveness, use of hazardous chemicals, formation of toxic end products and involvement of high-energy processes. To overcome these drawbacks, an alternative approach of environmentally benign and inexpensive biological synthesis mediated by plants or microbes has been essentially adopted. The variations in size, shape and surface chemistry of NPs affect the properties of metal NPs to a greater extent which in turn have an influence on their biological behaviour. Few metal NPs offer unique optical properties while others possess paramagnetic behaviour and quantum size effect which make them suitable in bio-imaging diagnostic techniques. Some metallic NPs play a role in tissue engineering and other therapeutic applications due to their ease of surface modifications, large surface area to volume ratio, unique electrical and anti-microbial activities. Instead of multi-disciplinary applications of metallic NPs, there is a great concern regarding the toxicity issues associated with the use of these NPs which need to be sorted out by looking out certain ways for favourable architecture involving the synthesis methods and parameters for designing the non-toxic NPs for improving the quality of life.

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Novel Polymer Systems for Gene Therapy

Diaz‐Dussan

Peng

Narain

2022

Macromolecular Engineering

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Gene therapy is a novel molecularly directed gene‐editing technique that can be used in treating gene‐related diseases, and its clinical relevance relies on the design of effective therapeutic vectors that are able to deliver and release the nucleic acids to the targeted sites. The use of nanoscale vectors for gene delivery presents various advantages such as improved bioavailability, extended nucleotide half‐life, and reduced off‐target toxicity. Several types of colloidal systems have been developed, including biocompatible polymer carriers, such as nanoparticles, nanocapsules, and branched polymers. A first requisite is biocompatibility; reducing cell cytotoxicity and effective clearance from the organism is one of the major challenges, and particle size is also a key factor in the internalization process. Common cationic gene carriers are summarized here, but their associated cytotoxicity or low efficacy restricted their use at the clinical level. Numerous modifications for enhancing the vectors are introduced, which mainly involved the incorporation of biocompatible units and degradability. Furthermore, several methods in preparing nonviral carrier via controlled radical polymerization and their related postmodification techniques are summarized and discussed. Furthermore, the new generation of therapeutic nanoparticles, which combined selective targeting moieties, and imaging agents, offers a theranostic approach for enhanced gene therapy.

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Protein−Polymer Nanoparticles for Nonviral Gene Delivery

Cited by 40 publications

References 53 publications

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Metallic Nanoparticles, Toxicity Issues and Applications in Medicine

Novel Polymer Systems for Gene Therapy

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