Protein phosphatase inhibitor-1 (PPI-1) has protective activities in stress conditions in E. coli

Kim, Thomas Doohun

doi:10.1016/j.ijbiomac.2006.01.001

Cited by 3 publications

(2 citation statements)

References 21 publications

(40 reference statements)

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“…Conceivably, RSS1 has broader roles in protecting proliferative tissues from cellular damage by stress, on the basis of the fact that the stress-responsive expression of several genes was enhanced in rss1 ; this may also be explained, in part, by the antisenescence activity of cytokinins37. Alternatively, RSS1 might have another biochemical function, as has been reported for protein phosphatase inhibitor-1, which has an extra activity in the protection of cellular proteins from the denaturation induced by abiotic stresses56.…”

Section: Discussionmentioning

confidence: 82%

RSS1 regulates the cell cycle and maintains meristematic activity under stress conditions in rice

et al. 2011

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Plant growth and development are sustained by continuous cell division in the meristems, which is perturbed by various environmental stresses. For the maintenance of meristematic functions, it is essential that cell division be coordinated with cell differentiation. However, it is unknown how the proliferative activities of the meristems and the coordination between cell division and differentiation are maintained under stressful conditions. Here we show that a rice protein, RSS1, whose stability is controlled by cell cycle phases, contributes to the vigour of meristematic cells and viability under salinity conditions. These effects of RSS1 are exerted by regulating the G1–S transition, possibly through an interaction of RSS1 with protein phosphatase 1, and are mediated by the phytohormone, cytokinin. RSS1 is conserved widely in plant lineages, except eudicots, suggesting that RSS1-dependent mechanisms might have been adopted in specific lineages during the evolutionary radiation of angiosperms.

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Section: Discussionmentioning

confidence: 82%

RSS1 regulates the cell cycle and maintains meristematic activity under stress conditions in rice

et al. 2011

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“…When phosphorylated by PKA, PPI-1 (phosphoprotein phosphatase inhibitor-1) can act as an inhibitor for various phosphatases. In the context of HMGCR regulation, it inhibits PP-2A (also known as HMGCR phosphatase), which removes phosphates from AMPK and HMGCR, and thus maintains HMGCR in the inactive state [68,69].…”

Section: Scenario 1c Modulating the Activity Of Phosphoprotein Phosph...mentioning

confidence: 99%

Cholesterol Metabolism Pathways Disturbances in Atherosclerosis—Analyses Using Stochastic Petri Net-Based Model

et al. 2023

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Atherosclerosis is a multifactorial disease that affects large arteries and causes much morbidity and mortality worldwide. Despite ongoing research for several decades, it is still a global health problem that cannot be stopped and cured completely. Furthermore, the development of this disease is contributed to by various processes, primarily disturbances in cholesterol metabolism, local low-grade inflammation, and oxidative stress, resulting in the formation of atherosclerotic plaques. In this work, a stochastic Petri net model was constructed and subsequently analyzed to examine the impact of these factors on the development and progression of atherosclerosis. The use of knockout- and simulation-based analysis allowed for a comprehensive investigation of the studied phenomena. Our research has demonstrated that while cholesterol is a contributing factor in atherosclerosis, blocking its impact alone is insufficient in halting the progression of this disorder. Inhibition of oxidative stress is also important when blocking the impact of phosphoprotein phosphatase inhibitor-1 (PPI-1), microsomal triglyceride transfer protein (MTTP), and 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGCR), as our model shows that this action reduces the number of foam cells underlying atherosclerosis. The results obtained further support the previous observations that the combined treatment is significantly effective in enhancing therapeutic efficacy against atherosclerosis.

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Identification of flooding stress responsible cascades in root and hypocotyl of soybean using proteome analysis

et al. 2009

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Flooding inducible proteins were analyzed using a proteomic technique to understand the mechanism of soybean response to immersion in water. Soybeans were germinated for 2 days, and then subjected to flooding for 2 days. Proteins were extracted from root and hypocotyl, separated by two-dimensional polyacrylamide gel electrophoresis, stained by Coomassie brilliant blue, and analyzed by protein sequencing and mass spectrometry. Out of 803 proteins, 21 proteins were significantly up-regulated, and seven proteins were down-regulated by flooding stress. Of the total, 11 up-regulated proteins were classified as related to protein destination/storage and three proteins to energy, while four down-regulated proteins were related to protein destination/storage and three proteins to disease/defense. The expression of 22 proteins significantly changed within 1 day after flooding stress. The effects of flooding, nitrogen substitution without flooding, or flooding with aeration were analyzed for 1-4 days. The expression of alcohol dehydrogenase increased remarkably by nitrogen substitution compared to flooding. The expression of many proteins that changed due to flooding showed the same tendencies observed for nitrogen substitution; however, the expression of proteins classified into protein destination/storage did not.

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Protein phosphatase inhibitor-1 (PPI-1) has protective activities in stress conditions in E. coli

Cited by 3 publications

References 21 publications

RSS1 regulates the cell cycle and maintains meristematic activity under stress conditions in rice

RSS1 regulates the cell cycle and maintains meristematic activity under stress conditions in rice

Cholesterol Metabolism Pathways Disturbances in Atherosclerosis—Analyses Using Stochastic Petri Net-Based Model

Identification of flooding stress responsible cascades in root and hypocotyl of soybean using proteome analysis

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