Protein Patterns of the Cerebrospinal Fluid in Children with Cerebral Palsy

Siemes, H.; Siegert, Martín J.; Rating, D.; Hanefeld, F.

doi:10.1055/s-0028-1091629

Cited by 3 publications

(1 citation statement)

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“…The concentration gradient between the serum and CSF is kept constant in adults (7). Under certain pathological conditions, such as dysfunction and damage of the BBB and production of immunoglobulins in the CNS the CSF/serum ratios of protein concentration are altered (8, 9). The CSF of newborns contains physiologically higher concentrations of protein than that of adults, and the CSF of preterm newborns contains higher concentrations of protein than that of term newborns (10).…”

Section: Discussionmentioning

confidence: 99%

Transfer of specific IgG and IgG subclasses to herpes simplex virus across the blood‐brain barrier and placenta in preterm and term newborns

et al. 1992

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The kinetics of virus-specific IgG subclasses (IgG 1-4) among newborns and their mothers has not yet been determined. In this report, we examined anti-herpes simplex virus IgG activities (HSV-IgG) and its subclasses in CSF and serum of premature or term newborns without HSV infection and in the serum of their mothers using ELISA. We found that CSF/serum ratios of HSV-IgG and IgG subclasses (IgG 1-4) in newborns with a gestational age less than 38 weeks were higher than those of term newborns. These findings indicate that the blood-brain barrier against HSV-IgG and IgG subclasses is insufficient in newborns. Furthermore, we found that HSV-IgG subclasses, which were transferred across the placenta and later transferred across the blood-brain barrier had a tendency to be proportional to each of the maternal HSV-IgG subclasses.

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Section: Discussionmentioning

confidence: 99%