Protein nanoparticles as natural drugs carriers for cancer therapy

Zaher, Sara; Soliman, Mahmoud E. S.; Elsabahy, Mahmoud; Hathout, Rania M.

doi:10.1007/s13596-022-00668-w

Cited by 9 publications

(5 citation statements)

References 77 publications

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“…This is mainly because they correspond to the typical size of the natural functional units of living organisms, which allows a better interaction with biomolecules. Several studies have shown that zein NPs loaded with different drugs, both hydrophobic and hydrophilic, can be used as drug delivery nano systems, designed to localize drugs at target sites through site-specific supply as a potential effective therapy in the treatment of cancers and other diseases [ 134 , 135 ]. Recently, quantum dots (QDs) have been incorporated into zein nanoparticles, where strong hydrogen bonding and hydrophobic interactions have been driving forces in the production of nanocomposites for bioimaging and drug-delivery applications [ 136 ].…”

Section: Potential Application Fields Of Zein Nanocarriersmentioning

confidence: 99%

Zein-Based Nanoparticles as Active Platforms for Sustainable Applications: Recent Advances and Perspectives

Oleandro,

Stanzione,

Buonocore

et al. 2024

Nanomaterials

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Nanomaterials, due to their unique structural and functional features, are widely investigated for potential applications in a wide range of industrial sectors. In this context, protein-based nanoparticles, given proteins’ abundance, non-toxicity, and stability, offer a promising and sustainable methodology for encapsulation and protection, and can be used in engineered nanocarriers that are capable of releasing active compounds on demand. Zein is a plant-based protein extracted from corn, and it is biocompatible, biodegradable, and amphiphilic. Several approaches and technologies are currently involved in zein-based nanoparticle preparation, such as antisolvent precipitation, spray drying, supercritical processes, coacervation, and emulsion procedures. Thanks to their peculiar characteristics, zein-based nanoparticles are widely used as nanocarriers of active compounds in targeted application fields such as drug delivery, bioimaging, or soft tissue engineering, as reported by others. The main goal of this review is to investigate the use of zein-based nanocarriers for different advanced applications including food/food packaging, cosmetics, and agriculture, which are attracting researchers’ efforts, and to exploit the future potential development of zein NPs in the field of cultural heritage, which is still relatively unexplored. Moreover, the presented overview focuses on several preparation methods (i.e., antisolvent processes, spry drying), correlating the different analyzed methodologies to NPs’ structural and functional properties and their capability to act as carriers of bioactive compounds, both to preserve their activity and to tune their release in specific working conditions.

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Section: Potential Application Fields Of Zein Nanocarriersmentioning

confidence: 99%

Zein-Based Nanoparticles as Active Platforms for Sustainable Applications: Recent Advances and Perspectives

Oleandro,

Stanzione,

Buonocore

et al. 2024

Nanomaterials

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“…These nanoparticles possess desirable characteristics including high biocompatibility, easy degradation, and low or non-toxicity, addressing some of the limitations associated with inorganic nanocarriers. Moreover, protein nanocarriers offer various advantages, such as high drug binding capacity and the ability to target tumors using specific ligands ( Zaher et al, 2023 ). The presence of surface functional groups on protein nanoparticles allows for easy modification.…”

Section: Nanomedicine Carriers Involved In the Therapy Of Lung Cancermentioning

confidence: 99%

Moving beyond traditional therapies: the role of nanomedicines in lung cancer

Zhang,

Li,

Guo

et al. 2024

Front. Pharmacol.

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Amidst a global rise in lung cancer occurrences, conventional therapies continue to pose substantial side effects and possess notable toxicities while lacking specificity. Counteracting this, the incorporation of nanomedicines can notably enhance drug delivery at tumor sites, extend a drug’s half-life and mitigate inadvertent toxic and adverse impacts on healthy tissues, substantially influencing lung cancer’s early detection and targeted therapy. Numerous studies signal that while the nano-characteristics of lung cancer nanomedicines play a pivotal role, further interplay with immune, photothermal, and genetic factors exist. This review posits that the progression towards multimodal combination therapies could potentially establish an efficacious platform for multimodal targeted lung cancer treatments. Current nanomedicines split into active and passive targeting. Active therapies focus on a single target, often with unsatisfactory results. Yet, developing combination systems targeting multiple sites could chart new paths in lung cancer therapy. Conversely, low drug delivery rates limit passive therapies. Utilizing the EPR effect to bind specific ligands on nanoparticles to tumor cell receptors might create a new regime combining active-passive targeting, potentially elevating the nanomedicines’ concentration at target sites. This review collates recent advancements through the lens of nanomedicine’s attributes for lung cancer therapeutics, the novel carrier classifications, targeted therapeutic modalities and their mechanisms, proposing that the emergence of multi-target nanocomposite therapeutics, combined active-passive targeting therapies and multimodal combined treatments will pioneer novel approaches and tools for future lung cancer clinical therapies.

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“…Autophagy induced by nanoparticles via endocytosis or other routes may have therapeutic effects, indicating biological applications, although their processing and destruction via selective autophagy remains unknown. Nanoparticles are foreign entities that are destroyed by cells [ 69 ]. Nanoparticles enter cells via endocytosis or other uptake routes.…”

Section: Targeting Autophagy Modulation To Eliminate Environmental Su...mentioning

confidence: 99%

The Emerging Role of Autophagy as a Target of Environmental Pollutants: An Update on Mechanisms

Rahman

Parvez

et al. 2023

Toxics

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Autophagy is an evolutionarily conserved cellular system crucial for cellular homeostasis that protects cells from a broad range of internal and extracellular stresses. Autophagy decreases metabolic load and toxicity by removing damaged cellular components. Environmental contaminants, particularly industrial substances, can influence autophagic flux by enhancing it as a protective response, preventing it, or converting its protective function into a pro-cell death mechanism. Environmental toxic materials are also notorious for their tendency to bioaccumulate and induce pathophysiological vulnerability. Many environmental pollutants have been found to influence stress which increases autophagy. Increasing autophagy was recently shown to improve stress resistance and reduce genetic damage. Moreover, suppressing autophagy or depleting its resources either increases or decreases toxicity, depending on the circumstances. The essential process of selective autophagy is utilized by mammalian cells in order to eliminate particulate matter, nanoparticles, toxic metals, and smoke exposure without inflicting damage on cytosolic components. Moreover, cigarette smoke and aging are the chief causes of chronic obstructive pulmonary disease (COPD)-emphysema; however, the disease’s molecular mechanism is poorly known. Therefore, understanding the impacts of environmental exposure via autophagy offers new approaches for risk assessment, protection, and preventative actions which will counter the harmful effects of environmental contaminants on human and animal health.

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Protein nanoparticles as natural drugs carriers for cancer therapy

Cited by 9 publications

References 77 publications

Zein-Based Nanoparticles as Active Platforms for Sustainable Applications: Recent Advances and Perspectives

Zein-Based Nanoparticles as Active Platforms for Sustainable Applications: Recent Advances and Perspectives

Moving beyond traditional therapies: the role of nanomedicines in lung cancer

The Emerging Role of Autophagy as a Target of Environmental Pollutants: An Update on Mechanisms

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