Protein Nanocarriers for Targeted Drug Delivery

Rezaei, Leila; Safavi, Maryam Sadat; Shojaosadati, Seyed Abbas

doi:10.1016/b978-0-12-814031-4.00008-8

Cited by 12 publications

(15 citation statements)

References 70 publications

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“…They possess an excellent interaction with other molecules, stabilizing and emulsification properties and water-binding capacity [ 56 ]. Furthermore, caseins are inexpensive, non-toxic, and biodegradable and highly available [ 57 ].…”

Section: Application Of the Proteins Derived From The Milk By-prodmentioning

confidence: 99%

“…Nowadays, casein hydrogels have been used for the delivery of bioactive compounds within nutraceuticals, pharmaceutics and cosmetics (hydrating and antiwrinkle agents) [ 61 , 63 ]. However, other forms, such as films, micelles, micro- and nanoparticles, can be used in drug and enzymatic delivery [ 57 , 61 ].…”

Section: Application Of the Proteins Derived From The Milk By-prodmentioning

confidence: 99%

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Proteins Derived from the Dairy Losses and By-Products as Raw Materials for Non-Food Applications

Costa

Azóia

Coelho

et al. 2021

Foods

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The disposal of a high volume of waste-containing proteins is becoming increasingly challenging in a society that is aware of what is happening in the environment. The dairy industry generates several by-products that contain vast amounts of compounds, including proteins that are of industrial importance and for which new uses are being sought. This article provides a comprehensive review of the potential of the valorisation of proteins that can be recovered by chemical and/or physical processes from protein-containing milk by-products or milk surplus, particularly whey proteins or caseins. Whey proteins and casein characteristics, and applications in non-food industries, with special emphasis on the textile industry, packaging and biomedical, are reported in this review, in order to provide knowledge and raise awareness of the sustainability of these proteins to potentiate new opportunities in a circular economy context.

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Section: Application Of the Proteins Derived From The Milk By-prodmentioning

confidence: 99%

Section: Application Of the Proteins Derived From The Milk By-prodmentioning

confidence: 99%

Proteins Derived from the Dairy Losses and By-Products as Raw Materials for Non-Food Applications

Costa

Azóia

Coelho

et al. 2021

Foods

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“…Vegetal proteins are characterized by greater amounts of hydrophobic amino acids as compared to animal proteins and are, therefore, generally more lipophilic [19,20]. Starting from this perspective, the aim of this review is to provide the state of the art concerning the development of drug delivery systems made up of the leading plant proteins currently being used in the pre-formulation investigations and that are available on the market, i.e., gliadin, legumin, soy and zein, besides their antitumor applications.…”

Section: Nanotechnology and Cancer Therapymentioning

confidence: 99%

“…Because of the hydrophobic character of the phospholipid bilayer, high polar and ionic systems are unable to cross the cell membrane by means of passive diffusion; therefore, mechanisms of active uptake represent the main phenomena that modulate the intracellular localization of nanovectors [21]. The uptake of polymeric nanoparticles is often characterized by an energy-dependent process known as endocytosis that Vegetal proteins are characterized by greater amounts of hydrophobic amino acids as compared to animal proteins and are, therefore, generally more lipophilic [19,20]. Starting from this perspective, the aim of this review is to provide the state of the art concerning the development of drug delivery systems made up of the leading plant proteins currently being used in the pre-formulation investigations and that are available on the market, i.e., gliadin, legumin, soy and zein, besides their antitumor applications.…”

Section: Mechanisms Of Cell Uptakementioning

confidence: 99%

“…Among natural polymers, proteins such as casein, albumin and silk are currently being used for anticancer purposes [69][70][71]. Plant proteins, such as zein and gliadins, have drawn great interest in the last decade because they have been used to develop various biocompatible nanocarriers for anticancer purposes [19].…”

Section: Plant-protein Based Drug Delivery Systems: Manufacturing Promentioning

confidence: 99%

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Antitumor Features of Vegetal Protein-Based Nanotherapeutics

et al. 2020

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The introduction of nanotechnology into pharmaceutical application revolutionized the administration of antitumor drugs through the modulation of their accumulation in specific organs/body compartments, a decrease in their side-effects and their controlled release from innovative systems. The use of plant-derived proteins as innovative, safe and renewable raw materials to be used for the development of polymeric nanoparticles unlocked a new scenario in the drug delivery field. In particular, the reduced size of the colloidal systems combined with the peculiar properties of non-immunogenic polymers favored the characterization and evaluation of the pharmacological activity of the novel nanoformulations. The aim of this review is to describe the physico-chemical properties of nanoparticles composed of vegetal proteins used to retain and deliver anticancer drugs, together with the most important preparation methods and the pharmacological features of these potential nanomedicines.

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Optimizing the synthesis of interleukin‐12‐loaded PLGA nanospheres (rmIL‐12ns) via ultrasonication for treatment of metastatic osteosarcoma

Lacinski

Markel

Pratt

et al. 2022

Journal Orthopaedic Research

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Clinical trials exploring bolus intravenous delivery of interleukin‐12 (IL‐12) for treatment of solid tumors ultimately failed due to lack of clinical response and severe dose‐limiting toxicities. The present study was conducted to evaluate whether recombinant murine IL‐12 (rmIL‐12) could be successfully encapsulated within Poly (D, l‐lactide‐co‐glycolide) (PLGA) nanospheres (rmIL‐12ns) for safe and effective systemic delivery at pharmacologic scale. Optimal fabrication of rmIL‐12ns occurs with dichloromethane as the organic solvent and emulsion formation via ultrasonication at 50% power (250 W sonicator) for 10 s (50W10s). We then determined whether utilization of synthesis modifiers including fetal bovine serum (FBS), magnesium hydroxide [Mg(OH)2], trehalose, or the surfactants polysorbate 80 and Span 60 alone or in combination could increase the encapsulation efficiency (EE) and/or modify the burst elution profile characteristic of the 50W10s rmIL‐12ns formulation. The greatest EEs compared to the unmodified formulation were measured with modifications containing the surfactants polysorbate 80 and Span 60 (surfactant: 28.3 ± 6.10%, p = 0.29 and Surf/FBS: 85.4 ± 2.19%, p = 0.039). The Surf/FBS formulation was further modified for in vivo murine injection by substituting FBS with mouse serum albumin (MSA). The resulting Surf/MSA rmIL‐12ns were then characterized before delivery at three doses (0.1, 1, and 10 mg rmIL‐12ns) in our established murine model of metastatic osteosarcoma to assess efficacy. Preliminary results suggested no evidence of disease with delivery of the 0.1 mg dose in 75% of mice (3 of 4) versus a nontreated historical control (2 of 34).

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Protein Nanocarriers for Targeted Drug Delivery

Cited by 12 publications

References 70 publications

Proteins Derived from the Dairy Losses and By-Products as Raw Materials for Non-Food Applications

Proteins Derived from the Dairy Losses and By-Products as Raw Materials for Non-Food Applications

Antitumor Features of Vegetal Protein-Based Nanotherapeutics

Optimizing the synthesis of interleukin‐12‐loaded PLGA nanospheres (rmIL‐12ns) via ultrasonication for treatment of metastatic osteosarcoma

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