“…10,11,15,18–45 However, this data collection strategy suffers from the need to grow and efficiently manipulate a large number of fragile micro-crystals. Reported methods include the mounting of many crystals using traditional, loop-style holders, 38,46 a variety of fixed-target architectures, 4,6,11,47–55 and different micro-crystal injection strategies 10,52,56–63 However, nearly all of these strategies have focused on transferring a pre-prepared slurry of micro-crystals onto a mount or into an injector, rather than coupling the processes of crystallization and X-ray analysis. 6,10,47,48,62 This requirement for physical handling introduces the need for additional experimental procedures, can potentially damage fragile or sensitive crystals, and particularly in the case of micro-crystal injection jets, can lead to inefficient sample utilization 6,10,47,48,62 …”