Protein-mediated boundary lubrication in arthroplasty

Heuberger, Manfred; Widmer, M.R.; Zobeley, Eva; Glockshuber, Rudi; Spencer, Nicholas D.

doi:10.1016/j.biomaterials.2004.05.020

Cited by 156 publications

(151 citation statements)

References 43 publications

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“…The use of saline resulted in the highest wear rate of 0.89 ± 0.08 and 1.23 ± 0.07 mm 3 /Mc (Groups 4 and 5, respectively). The higher wear rate for Group 4 was expected, given that saline lacks any lubricating proteins [30], and yielded the opposite result of polymer on metal articulations [17,18]. Given the lack of evidence for third body wear from the imaging assessment for Group 5 as compared to Group 4, it is believed that slow dissolution of the coating and/or physical removal of the HA coating during specimen handling during testing is responsible for the difference in mass loss; the cycle intervals were decreased to minimize handling of the coated devices.…”

Section: Discussionmentioning

confidence: 83%

The use of self-mating PEEK as an alternative bearing material for cervical disc arthroplasty: a comparison of different simulator inputs and tribological environments

Brown

Bao

2012

Eur Spine J

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Purpose The hypothesis for this study was that the simulated wear behavior of a hydroxyapatite coated, selfmating PEEK cervical disc arthroplasty device would be dependent on the simulated testing environment. Methods Five groups of devices were evaluated under suggested ASTM and ISO load and motion profiles. The groups utilized different testing frequencies and protein content of simulator fluid, in addition to assessing the potential for third body wear. The average wear rates were determined using linear regression analysis with a generalized estimating equation. Significant differences between groups were determined using the Wald's test. Results The simulated wear behavior was shown to be highly dependent on the testing environment, where protein content more than decreasing the cyclic loading frequency resulted in increased wear, but was not dependent on the suggested load and motion profiles. It was demonstrated that a self-mating PEEK cervical disc arthroplasty device has wear rates that are similar to existing material combinations for cervical disc arthroplasty. Conclusions This study showed that at a time when data from retrieval analyses is deficient, it is important to test the wear resistance of cervical disc arthroplasty devices under various conditions. Long-term clinical results and ongoing implant retrievals are required for validation between clinical performance and simulator inputs.

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Section: Discussionmentioning

confidence: 83%

The use of self-mating PEEK as an alternative bearing material for cervical disc arthroplasty: a comparison of different simulator inputs and tribological environments

Brown

Bao

2012

Eur Spine J

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“…The C-terminus of statherin has been previously shown to be key to the lubricative action of statherin on tooth enamel, and the connection between helical secondary structure and viscoelastic function has been made with human serum albumin [90]. The folding of statherin's C-terminus into an α-helical conformation thus serves as a structural context to understand both fimbrillin binding and consequently bacterial adhesion, as well as the important lubricative properties of bound statherin.…”

Section: Discussionmentioning

confidence: 99%

Solid state NMR studies of molecular recognition at protein–mineral interfaces

Goobes

Stayton

Drobny

2007

Progress in Nuclear Magnetic Resonance Spectroscopy

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“…Protein solutions have been shown to reduce friction and wear in several studies [5][6][7][8], commonly attributed to an 'adsorbed' protein film. Buffers are used when preparing protein solutions to control the pH and ionic strength of the solution.…”

Section: Introductionmentioning

confidence: 99%

“…However, the effect of the buffer composition on protein film formation is generally not acknowledged. Protein adsorption is a complicated phenomenon, influenced by many factors, such as solution pH [9,10], ionic concentration [11] , protein concentration [12], hydrophobic interactions [13] and protein conformation [7]. As buffers vary in chemistry, pH and ionic strength, the choice of buffer will impact on the protein adsorption to test surfaces, including the rate of adsorption, total adsorbed amounts, reversibility of adsorption, and the properties of an adsorbed layer.…”

Section: Introductionmentioning

confidence: 99%

The effect of buffer solution choice on protein adsorption and lubrication

Parkes

Myant

Cann

et al. 2014

Tribology International

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Submission Abstract (max 120 words)In vitro buffers are frequently used to formulate model synovial fluids to investigate the role of individual constituents in synovial joint lubrication. This work examines how buffer choice affects protein film formation in static and rolling conditions. Solution pH dominates both the protein adsorption kinetics and the formation of tribofilms in static and rolling conditions respectively. Under static conditions, equilibrium adsorbed protein films from all buffers tested have similar properties although three distinct modes of adsorption, governed by the pH of the buffer, are observed. Films formed under rolling conditions are also pH dependent, with large irregular deposits formed in solutions with pH 7.4 or lower, The adsorption properties of proteins under static conditions only partially govern the lubrication properties of proteins. AbstractSynovial fluid contains proteins which can participate in surface film formation and the lubrication of artificial joints. In laboratory experiments, model synovial fluids with a range of buffers are frequently used by various investigators. Buffer compositions with different pH, ionic strength and buffer chemistry may affect protein adsorption, and hence film formation. To clarify the role of buffers in protein film formations, the static adsorption of BSA in a selection of buffers is studied using a quartz crystal microbalance. Three distinct modes of adsorption are observed, but on reaching equilibrium, the adsorbed BSA layers have similar viscoelastic properties in all buffer solutions. The static adsorption results are compared with lubricants film formed in model rolling contacts. Films formed under rolling conditions are pH dependent. Thin, uniform films consistent with adsorbed films, and nonuniform films, with large irregular deposits are formed in high and low pH solutions respectively. The results show that the pH of the solution dominates both the adsorption kinetics of proteins under static conditions and the formation of tribofilms in rolling conditions. However, the adsorption properties of proteins under static conditions only partially govern the lubrication property of protein solutions.

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Protein-mediated boundary lubrication in arthroplasty

Cited by 156 publications

References 43 publications

The use of self-mating PEEK as an alternative bearing material for cervical disc arthroplasty: a comparison of different simulator inputs and tribological environments

The use of self-mating PEEK as an alternative bearing material for cervical disc arthroplasty: a comparison of different simulator inputs and tribological environments

Solid state NMR studies of molecular recognition at protein–mineral interfaces

The effect of buffer solution choice on protein adsorption and lubrication

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