Protein-Inspired Materials: Synthetic Concepts and Potential Applications

Klok, Harm‐Anton

doi:10.1002/1521-3773(20020503)41:9<1509::aid-anie1509>3.0.co;2-k

Cited by 74 publications

(50 citation statements)

References 38 publications

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“…[36][37][38][39] Bearing multifunctional building blocks and labile structural functionalities, such biopolymers have greatly benefited from click chemistry.…”

Section: Peptidesmentioning

confidence: 99%

Click Chemistry: A Powerful Tool to Create Polymer‐Based Macromolecular Chimeras

Droumaguet

Velonia

2008

Macromol. Rapid Commun.

175

111

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The combination of polymeric with biological materials, to create biohybrid macromolecules that merge the properties of both the natural and synthetic components, is a flourishing area in both life sciences and biotechnology. The click chemistry philosophy has recently provided a powerful tool in this direction, leading to a plethora of novel, tailor‐made biomacromolecules with unprecedented structural characteristics and properties. The different synthetic strategies, using the alkyne–azide click cycloadditions to bioorthogonally achieve the coupling of synthetic polymers with nucleic acids, peptides, sugars, proteins or even viruses and cells is described. The review covers the latest developments in this very dynamic and rapidly expanding field.magnified image

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“…[36][37][38][39] Bearing multifunctional building blocks and labile structural functionalities, such biopolymers have greatly benefited from click chemistry.…”

Section: Peptidesmentioning

confidence: 99%

Click Chemistry: A Powerful Tool to Create Polymer‐Based Macromolecular Chimeras

Droumaguet

Velonia

2008

Macromol. Rapid Commun.

175

111

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“…Researchers have utilized various approaches in the synthesis of peptide building units while minimizing other possible byproducts [24]. To self-assemble peptides into nanostructures, there are mainly three approaches: solid-phase peptide synthesis, ring-opening polymerization, and protein engineering [25]. The solid-phase peptide synthesis is utilized to precisely control the peptide structure with short or medium sequences.…”

Section: Introductionmentioning

confidence: 99%

“…In this method, cyclic monomers are introduced to the end of the sequences to form a longer peptide. On the other hand, a lower accuracy of the peptide primary structure than other methods such as solid-phase peptide synthesis is noticed using this method [25].…”

Section: Introductionmentioning

confidence: 99%

Peptide Self-Assembled Nanostructures for Drug Delivery Applications

Fan

Shen

et al. 2017

Journal of Nanomaterials

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Peptide self-assembled nanostructures are very popular in many biomedical applications. Drug delivery is one of the most promising applications among them. The tremendous advantages for peptide self-assembled nanostructures include good biocompatibility, low cost, tunable bioactivity, high drug loading capacities, chemical diversity, specific targeting, and stimuli responsive drug delivery at disease sites. Peptide self-assembled nanostructures such as nanoparticles, nanotubes, nanofibers, and hydrogels have been investigated by many researchers for drug delivery applications. In this review, the underlying mechanisms for the self-assembled nanostructures based on peptides with different types and structures are introduced and discussed. Peptide self-assembled nanostructures associated promising drug delivery applications such as anticancer drug and gene drug delivery are highlighted. Furthermore, peptide self-assembled nanostructures for targeted and stimuli responsive drug delivery applications are also reviewed and discussed.

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“…However, this method produces a peptide primary structure with a lower accuracy than that obtained during solid-phase synthesis. 14 In this review, we would like to introduce self-assembled nanostructures (nanospheres, nanotubes, nanofibers, and other ordered nanostructures) with linear peptide monomers (amphiphilic peptides, ionic-complementary peptides, etc) and nonlinear peptide monomers (cyclic peptides and hybrid peptides) as building blocks and discuss some relevant recent applications of such molecules involved during drug delivery, tissue engineering, antimicrobial control, and electronic devices ( Figure 1). …”

Section: Introductionmentioning

confidence: 99%