2017
DOI: 10.1002/14651858.cd012412.pub2
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Protein hydrolysate versus standard formula for preterm infants

Abstract: The identified trials provide only low quality evidence about the effects of feeding preterm infants with protein hydrolysate versus standard formula. The existing data did not support conclusions that feeding with protein hydrolysate affects the risk of feed intolerance or necrotising enterocolitis. Further large, pragmatic trials are needed to provide more reliable and precise estimates of effectiveness and cost-effectiveness.

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Cited by 10 publications
(9 citation statements)
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“…The 2019 Cochrane Review by Ng and colleagues has recently confirmed that existing data fail to demonstrate any harm or benefit of such prophylactic PH use. Larger (strictly regulated and expensive) trials are again warranted, but it is unlikely that anyone will be willing to take the risk of the null hypothesis coming from such a distressing starting ground.…”
mentioning
confidence: 99%
“…The 2019 Cochrane Review by Ng and colleagues has recently confirmed that existing data fail to demonstrate any harm or benefit of such prophylactic PH use. Larger (strictly regulated and expensive) trials are again warranted, but it is unlikely that anyone will be willing to take the risk of the null hypothesis coming from such a distressing starting ground.…”
mentioning
confidence: 99%
“…In our country, undiluted preterm formula (PF) is the second choice for MEF since there is no established human milk bank. It is not recommended to use the protein hydrolyzed formulas (7). MEF is applied for 1-3 days at 10-20 mL/kg according to the birth weight.…”
Section: Enteral Feeding Methodsmentioning
confidence: 99%
“…On the other hand, hydrolysed formulas have been reported to promote more efficient protein digestion, even though available data are not conclusive. 24 Remarkably, human milk contains both proteases and antiproteases that probably modulate the proteolysis that occurs within the mammary gland. Higher concentrations of hydrolysed proteins, mainly caseins, have been found in preterm milk relative to term milk.…”
Section: Enteral Nutritionmentioning
confidence: 99%