Protein glycosylation in diabetes mellitus: biochemical and clinical considerations

Stanaway, S.E.R.S.; Gill, GV

doi:10.1002/(sici)1528-252x(200001)17:1<21::aid-pdi4>3.0.co;2-5

Cited by 14 publications

(9 citation statements)

References 38 publications

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“…Tendon morphology and micro‐scopy may be abnormal in diabetes,5 possibly as a result of protein glycosylation related to long‐term hyperglycaemia 6. This may lead to spontaneous rupture, which in the presence of sensory neuropathy may be painless, and remain unnoticed until swelling occurs,1 as in our case.…”

Section: Discussionmentioning

confidence: 62%

Spontaneous rupture of the peroneus longus tendon in a patient with diabetic sensory neuropathy

et al. 2011

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We present a case of spontaneous painless rupture of the peroneus longus tendon in a patient with poorly controlled type 2 diabetes and a distal sensory neuropathy. Tendon rupture in the diabetic neuropathic foot has been previously described, but not of the peroneus longus tendon. Painless tendon rupture in the diabetic foot or ankle can present a diagnostic challenge, and requires a high index of suspicion. Copyright © 2011 John Wiley & Sons.

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Section: Discussionmentioning

confidence: 62%

Spontaneous rupture of the peroneus longus tendon in a patient with diabetic sensory neuropathy

et al. 2011

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“…21 Hyperglycemia leads to increase protein glycation hence the high levels of glycated hemoglobin seen. 22 Higher BMI in diabetics compared to controls have been previously demonstrated. Increased BMI has been associated with increased risk for diabetes starting at a BMI as low as 21 kg/m 2 .…”

Section: Discussionmentioning

confidence: 80%

Adiponectin and cardiovascular risk factors in relation with glycemic control in type 2 diabetics

et al. 2013

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Background: Adiponectin has been associated with insulin resistance and dyslipidemia in Type 2 diabetes, though the mechanism of association is still uncertain. The adiponectin levels and lipid profile in relation to glycemic control were investigated in type 2 diabetics. Methods: Forty two diabetic subjects (35-64 years) and 33 age-matched non-diabetic subjects were recruited into this case control study. Socio-demographic characteristics, anthropometric indices and blood pressure were obtained. Total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein, (HDL), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c) were estimated using colorimetric methods, atherogenic index (AI) was calculated, while serum adiponectin was determined by ELISA method. Results: Adiponectin levels of type 2 diabetics were not significantly different from the non-diabetics studied (p>0.05). Higher TG levels were observed in diabetics with poor glycemic control compared with those with good glycemic control (p<0.05). Hypertensive diabetics have higher TC and lower HDL-C levels compared with non hypertensive diabetics (p<0.05). Adiponectin correlated positively with HDL-C (r = 0.739, p = 0.01) and negatively with AI (r = -0.539, p = 0.001) only in the non diabetic group. No significant differences were observed in the adiponectin levels in relation with gender, duration of diabetes and glycemic state (p>0.05). Conclusion: Type 2 diabetics do not have lower adiponectin levels. Gender, duration of diabetes and glycemic control does not seem to exert any influence on adiponectin levels in type 2 diabetes. Adiponectin may be associated with reduced risk of atherosclerosis through its effects on HDL cholesterol metabolism. [Int J Res Med Sci 2013; 1(4.000): 563-570

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“…This binding could also happen non-enzymatically as found in glycated hemoglobin, glycated albumin, and AGEs. Both forms of protein glycosylation have been proven to be induced by the abundance of sugar substrate [11].…”

Section: Introductionmentioning

confidence: 99%

CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults

Ali

Mirza

Naquiallah

et al. 2021

JCDD

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CD147 is a glycoprotein that stimulates the production of matrix metalloproteinases (MMPs), known contributors to cardiovascular risk. The activity of CD147 protein depends on its glycosylation. However, it is unclear whether CD147 protein expression or glycosylation are influenced by the diabetic milieu characterized by hyperglycemia and abundant glycation-end-products (AGEs). We examined the circulating and visceral adipose tissue (VAT) levels of CD147 and their correlation with vascular function in obese, obese diabetic, and non-obese controls (n = 40, each). The circulating levels of CD147 and the glycosylated CD147 protein in VAT were considerably higher in obese, particularly obese diabetic subjects compared to controls. Obese diabetics had the lowest brachial and arteriolar vasoreactivity and the highest carotid pulse-wave velocity (PWV, a measure of arterial stiffness) among the three groups. CD147 correlated positively with body mass index (BMI), total and visceral fat mass, PWV, and plasma levels of glucose, insulin, MMPs, and AGEs and negatively with brachial artery and VAT-arteriolar vasoreactivity and nitric oxide production. Multivariate regression revealed that BMI, body fat mass, insulin, and glucose levels significantly predicted CD147. Our data suggest that higher levels of CD147 in obese subjects, particularly those with diabetes, are linked to vascular dysfunction and several cardiometabolic risk factors.

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Protein glycosylation in diabetes mellitus: biochemical and clinical considerations

Cited by 14 publications

References 38 publications

Spontaneous rupture of the peroneus longus tendon in a patient with diabetic sensory neuropathy

Spontaneous rupture of the peroneus longus tendon in a patient with diabetic sensory neuropathy

Adiponectin and cardiovascular risk factors in relation with glycemic control in type 2 diabetics

CD147 Levels in Blood and Adipose Tissues Correlate with Vascular Dysfunction in Obese Diabetic Adults

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