Adiponectin and cardiovascular risk factors in relation with glycemic control in type 2 diabetics

Abstract

Background: Adiponectin has been associated with insulin resistance and dyslipidemia in Type 2 diabetes, though the mechanism of association is still uncertain. The adiponectin levels and lipid profile in relation to glycemic control were investigated in type 2 diabetics. Methods: Forty two diabetic subjects (35-64 years) and 33 age-matched non-diabetic subjects were recruited into this case control study. Socio-demographic characteristics, anthropometric indices and blood pressure were obtained. Total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein, (HDL), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c) were estimated using colorimetric methods, atherogenic index (AI) was calculated, while serum adiponectin was determined by ELISA method. Results: Adiponectin levels of type 2 diabetics were not significantly different from the non-diabetics studied (p>0.05). Higher TG levels were observed in diabetics with poor glycemic control compared with those with good glycemic control (p<0.05). Hypertensive diabetics have higher TC and lower HDL-C levels compared with non hypertensive diabetics (p<0.05). Adiponectin correlated positively with HDL-C (r = 0.739, p = 0.01) and negatively with AI (r = -0.539, p = 0.001) only in the non diabetic group. No significant differences were observed in the adiponectin levels in relation with gender, duration of diabetes and glycemic state (p>0.05). Conclusion: Type 2 diabetics do not have lower adiponectin levels. Gender, duration of diabetes and glycemic control does not seem to exert any influence on adiponectin levels in type 2 diabetes. Adiponectin may be associated with reduced risk of atherosclerosis through its effects on HDL cholesterol metabolism. [Int J Res Med Sci 2013; 1(4.000): 563-570

Study of Serum Adiponectin and High Sensitivity C-Reactive Protein in Diabetic Patients

“…Festa et al suggested that people developing DM had higher baseline levels of hs-CRP than in controls [24], thus supporting our study. [25]. Another study of Ljubic et al also reported the similar result [26].…”

Reduced Serum Adiponectin Levels in Type 2 Diabetic Patients in Zaria

“…Weyer et al also reported a negative association between adiponectin and type 2 diabetes and obesity [9]. Obot, et al however, did not report any significant difference in adiponectin values in their work among type 2 diabetics and controls [10]. This could be as a result of the fewer number of subjects that were studied.…”

Correlation Oflipid Profile With Glycated Hemoglobin (Hba1c) in Diabetic Patients in King Abdullah Hospital, Bisha, Saudi Arabia

“…It is reported that the level of HbA 1C ≥6.0% was associated with increased risk of diabetic complications (Edelam, et al 2004). Development of diabetic complications was associated with the level of glycemic controlwhich it is assessed by HbA 1C level (Obot, et al 2013). Hence, patients in this study are at high risk of diabetic complication.…”