Protein Glycation Inhibitory and Antioxidative Activities of Some Plant Extracts in Vitro

Kim, Hye Young; Kim, Kyong

doi:10.1021/jf020850t

Cited by 96 publications

(79 citation statements)

References 24 publications

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“…The results from this study revealed that the all prepared extracts possessed antiprotein glycation. These findings correlated with those reported by other investigators about antiglycation efficacy of some natural plants, such as Allium cepa L. [32] , Curcuma longa L. [33] , Rosmarinus officinalis L. [34] , Cinnamomum verum [35] and Origanum officinalis [36] under in vitro conditions. Under identical conditions, the antiglycation potential of extracts on albumin was higher than hemoglobin, and crystalline glycation, respectively.…”

Section: Resultssupporting

confidence: 92%

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Faezizadeh¹,

Ghorbanihaghjo²,

Godarzee³

2016

ijps

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Faezizadeh, et al.: Antiglycation Effects of Some Boraginaceae SpeciesNon-enzymatic glycation of proteins is the major cause of diabetic complications and therefore, inhibition of this reaction could reduce the morbidity of this disease. The aim of this study was to evaluate the in vitro effects of aqueous and hydroethanol extracts of Echium italicum L., Anchusa arvensis L. and Trichodesma incanum (Bunge) A. DC. of Boraginaceae on albumin, hemoglobin, and crystalline glycation reaction. The results showed that the hydroethanol extract of Echium italicum in the concentrations of 100, 50 and 10 mg/dl could reduce the rate of albumin glycation to 85.10±1.85, 64.14±1.12 and 40.13±1.17%, respectively, and also in the same conditions, rates of hemoglobin glycation were reduced to 69.20±1.71, 46.13±1.93 and 27.73±0.90%, respectively. Moreover, extracts of three tested plants have antiglycation effects on crystalline glycation reaction. Under the identical conditions, the inhibitory effects of hydroethanol extracts of Echium italicum on the albumin, hemoglobin, and crystalline glycation reaction were higher than other extracts. The findings showed that the extracts of tested species, particularly in the hydroethanol form, could be used to prevent and treat complications of diabetes mellitus. Key words: Echium italicum L., Anchusa arvensis L., Trichodesma incanum (Bunge) A. DC., albumin, hemoglobin, glycationMembers of the family Boraginaceae include herbs, shrubs and trees totaling about 146 genera and 2000 species in the worldwide [1] . Some of these plants grow in Iran and used widely in Iran's folk medicine [2,3] . It has been reported that Borage (Borago officinalis L.) was useful for its antipyretic, antihypertensive, antispasmodic, aphrodisiac and diuretic properties [4,5] . Previous findings showed that some species of Boraginaceae were used for the treatment of hemorrhoids [6] . Furthermore, it has also been observed that various parts of Echium species could be used for their antiinflammatory, antibacterial, antidepressant, antiproliferative, antiviral, antioxidant, cytotoxic and anxiolytic properties [2,3] . Cyanidin, a natural phenolic compound is present in many kinds of plants, such as grapes, pomegranate and some species of Boraginaceae and according to the previous reports, this effective compound has antioxidant and antidiabetic potential [7][8][9][10] .Diabetes mellitus is a common endocrine disease and a leading cause of morbidity and mortality in the world [11] . In this disease, the macro and microvascular complications lead to severe effects on the eyes, central nervous systems and kidneys [12] . Evidence from in vitro and in vivo experiments indicated that diabetic hyperglycemia could increase the risk of complications [13,14] . It seems that non-enzymatic glycation plays an important role in progression of diabetic complications [11] . Due to prolonged hyperglycemia, the non-enzymatic glycation of proteins could significantly change their structural and functional properties [12] . Previous studie...

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Section: Resultssupporting

confidence: 92%

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Faezizadeh¹,

Ghorbanihaghjo²,

Godarzee³

2016

ijps

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“…Actually I. anisatum is a neurotoxic plant because it contains sesquiterpenic lactones. Recent studies have shown that various parts of I. anisatum possess the inhibitory activities of aldose reductase, lipase and glycation as well as antioxidant activity (2)(3)(4). The phenolic compounds of leaf oil include 1-allyl-2-methoxy-4,5-methylenedioxybenzene, 4-allyl-2,6-dimethoxyphenol, 1-allyl-3-methoxy-4-(3--methylbut-2-enyloxy) benzene and 1-allyl-3,5-dimethoxy-4-(3-methylbut-2-enyloxy) benzene (5).…”

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confidence: 99%

Chemical composition, antioxidant, anti-elastase, and anti-inflammatory activities of Illicium anisatum essential oil

Kim

Kim²,

Oh³

et al. 2009

Acta Pharmaceutica

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Illicium is a genus of flowering plants comprising 42 species of evergreen shrubs and small trees, and is the sole genus in the family Illiciaceae. The species are native to the tropical and subtropical regions of eastern and southeastern Asia, southeastern North America and the West Indies. Illicium anisatum (also known as I. religiosum, I. japonicum, shikimmi and skimmi) is distributed throughout eastern Asia where it is used as an orna- The essential oil of air-dried Illicium anisatum (Illiciaceae), obtained by hydrodistillation was analyzed by gas chromatography-mass spectrometry (GC-MS). Fifty-two components were identified in the essential oil and the main component was eucalyptol (21.8 %). The antioxidant and anti-elastase activities of the essential oil were also investigated; the essential oil exhibited moderate DPPH scavenging and anti-elastase activities. To clarify the mechanism of the anti-inflammatory activities of I. anisatum essential oil (IAE), we evaluated whether it could modulate the production of nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) by activated macrophages. The results indicate that IAE is an effective inhibitor of LPS-induced NO and PGE 2 production in RAW 264.7 cells. These inhibitory activities were accompanied by dose-dependent decreases in the expression of iNOS and COX-2 proteins and iNOS and COX-2 mRNA. In order to determine whether IAE can be safely applied to human skin, the cytotoxic effects of IAE were determined by colorimetric MTT assays in human dermal fibroblast and keratinocyte HaCaT cells. IAE exhibited low cytotoxicity at 100 mg mL -1 . Based on these results, we suggest that IAE may be considered an anti-aging and anti-inflammatory candidate for cosmetic materials, but additional in vitro and in vivo tests have to be performed to prove its safety and efficacy.

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“…Anti-oxidative stress activity of A. sessiliflorus To exprotein glycation, one of cellular biomarkers of aging, was inhibited by the extracts from A. senticosus bark (Kim et al, 2003). The root and rhizome of A. senticosus showed neuroprotective effect on dopaminergic neurons in the model mice of Parkinson's disease, one of age-related neurodegenerative diseases (Liu et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Effect of Acanthopanax sessiliflorus Extracts on Stress Response and Aging in Caenorhabditis elegans

Kim

2013

FSTR

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Acanthopanax sessiliflorus has been used as traditional medicine in many diseases. The extracts from Acanthopanax sessiliflorus leaves were examined for their anti-oxidant activity in vivo. Resistance to oxidative stress was significantly increased by Acanthopanax sessiliflorus extracts. Since increased resistance to oxidative stress is commonly positively correlated with lifespan extension, we determined the effect of Acanthopanax sessiliflorus on lifespan of C. elegans. Both mean and maximum lifespan were markedly increased by Acanthopanax sessiliflorus extracts. In addition, the treatment of Acanthopanax sessiliflorus enhanced the survival of worms under heat stress. However, the reduced fertility or delayed reproduction period frequently accompanied with increased lifespan were not observed in Acanthopanax sessiliflorustreated animals. These findings suggest that Acanthopanax sessiliflorus leaves can confer longevity phenotype without reduced fertility, possibly through their anti-oxidant activity.Keywords: Acanthopanax sessiliflorus, Caenorhabditis elegans, oxidative stress, thermotolerance, aging *To whom correspondence should be addressed. E-mail: skpark@sch.ac.kr IntroductionCells produce free radicals as a byproduct of metabolism. Free radical theory of aging suggests that oxidative damages by free radicals in cellular macromolecules accumulate with aging and cause cellular dysfunction, tissue damage, and eventually organism's death (Harman, 1956; Beckman and Ames, 1998). Major cellular free radicals are reactive oxygen species (ROS) produced mainly from mitochondrial electron transport chain reaction. Cellular antioxidants can scavenge these ROS and prevent oxidative damage in DNA, protein, and lipid molecules. Based on ROS-scavenging activity of anti-oxidants, many antioxidants have been studied for their effect on aging. Resveratrol, a polyphenol compound found in red wine, extends lifespan in yeast, C. elegans, and drosophila (Howitz et al., 2003;Wood et al., 2004;Valenzano et al., 2006). Green tea polyphenols also conferred increased lifespan and reduced incidence of age-related diseases (Kitani et al., 2004). Supplementation of vitamin E significantly inhibited age-related transcriptional changes in mouse heart and brain (Park et al., 2008). Different anti-oxidants showed tissue-specific effects on the expression of transcriptional biomarkers of aging in mice (Park et al., 2009).Acanthopanax species belongs to Araliaceae plant family and is mainly found in Korea, Japan, and China. Previous studies identified biological active components of Acanthopanax species which include phenylpropanoids, lignins, sterols, coumarins, vitamins, minerals and mono-and polysaccharides (Jones and Albersheim, 1972;Jeong et al., 2006). Acanthopanax species have been used as traditional medicine to various diseases, including diabetes, gastric ulcer, tumors, hypertension, and rheumatoid arthritis (Jung and Shin, 2003;Fujikawa et al., 1996). The extracts from Acanthopanax sessiliflorus (A. sessiliflorus) showed immuno-...

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Protein Glycation Inhibitory and Antioxidative Activities of Some Plant Extracts in Vitro

Cited by 96 publications

References 24 publications

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Effects of Some Boraginaceae Species Extracts on Albumin, Hemoglobin and Crystalline Glycation Reaction

Chemical composition, antioxidant, anti-elastase, and anti-inflammatory activities of Illicium anisatum essential oil

Effect of Acanthopanax sessiliflorus Extracts on Stress Response and Aging in Caenorhabditis elegans

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