Protein‐Functionalized Synthetic Antiferromagnetic Nanoparticles for Biomolecule Detection and Magnetic Manipulation

Fu, Aihua; Hu, Wei; Xu, Li; Wilson, Robert; Heng, Yu; Osterfeld, Sebastian J.; Gambhir, Sanjiv S.; Wang, Shan X.

doi:10.1002/ange.200803994

Cited by 21 publications

(16 citation statements)

References 43 publications

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“…However, Fu et al [93] developed a simple surface-functionalization method for conjugating lithographically fabricated antiferromagnetic nanoparticles to a model protein, streptavidin. The streptavidin-functionalized synthetic antiferromagnetic nanoparticles (SAFs) could bind specifically to biotin, and exhibited tunable response to a small external magneticfield gradient (10 T/m).…”

Section: Magnetic Manipulationmentioning

confidence: 99%

Recent advances in biological detection with magnetic nanoparticles as a useful tool

Wang

Xiong

et al. 2015

Sci. China Chem.

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Section: Magnetic Manipulationmentioning

confidence: 99%

Recent advances in biological detection with magnetic nanoparticles as a useful tool

Wang

Xiong

et al. 2015

Sci. China Chem.

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“…The newly developed synthetic anti-ferromagnetic-layered nanoparticles allowed DNA detection with high sensitivity (10 pm) and tunable responses to a small external magnetic field gradient [102].…”

Section: Giant Magnetoresistance (Gmr) Sensormentioning

confidence: 99%

Detection of magnetic nanomaterials in molecular imaging and diagnosis applications

Yao

2014

Nanotechnology Reviews

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Advances in bionanotechnology promise to allow medical diagnosis and therapy through the channel of molecular imaging. Combining biological science and modern detection techniques, molecular imaging has the ability to penetrate biomedical processes at the molecular and cellular level. Magnetic nanoparticles (MNP), broadly defined as particles of tens of nm to approximately 2 μm in diameter in this review, are playing an increasingly important role in molecular imaging. They act as contrast agents to remarkably enhance the signal. The precise determination of the position and quantity of MNP is critical for these applications. This review describes the advances in the development of detection techniques for magnetic particles used in molecular imaging and diagnosis. The techniques are categorized as high magnetic field techniques and low magnetic field techniques. The high-field studies focus on magnetic resonance imaging (MRI). The ultralow-field (ULF) studies include several of the most recent techniques: giant magnetoresistance sensors, superconducting quantum interference devices, atomic magnetometers, and magnetic particle imaging. The advantages and disadvantages of each method are discussed.

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“…They are functionalized with organic or inorganic coatings to attain biocompatibility to target biomolecules. Table 3 summarizes the properties of various types of MNPs [53][54][55][56][57][58][59][60]. As the size of magnetic particles reduces to the nanometer scale, they exhibit superparamagnetism.…”

Section: Properties Of Magnetic Nanoparticles (Mnps)mentioning

confidence: 99%

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

et al. 2020

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Superparamagnetic nanoparticles are attracting significant attention. Therefore, being explored in microsystems for a wide range of applications. Typical examples include labon-a-chip and microfluidics for synthesis, detection, separation, and transportation of different bioanalytes, such as biomolecules, cells, and viruses to develop portable, sensitive, and cost-effective biosensing systems. Particularly, microfluidic systems incorporated with magnetic nanoparticles and, in combination with magnetoresistive sensors, shift diagnostic and analytical methods to a microscale level. In this context, nanotechnology enables the miniaturization and integration of a variety of analytical functions in a single chip for manipulation, detection, and recognition of bioanalytes reliably and flexibly. In consideration of the above, recent development and benefits are elaborated herein to discuss the role of magnetic nanoparticles inside the microchannels to design highly efficient disposable point-of-care applications from transportation to the detection of bioanalytes.

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Protein‐Functionalized Synthetic Antiferromagnetic Nanoparticles for Biomolecule Detection and Magnetic Manipulation

Cited by 21 publications

References 43 publications

Recent advances in biological detection with magnetic nanoparticles as a useful tool

Recent advances in biological detection with magnetic nanoparticles as a useful tool

Detection of magnetic nanomaterials in molecular imaging and diagnosis applications

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

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